Characteristics of pediatric patients with 11q23/MLL-rearranged AML grouped on the basis of translocation partners
| . | Total . | t(9;11)(p22;q23) . | t(10;11)(p12;q23) . | t(6;11)(q27;q23) . | t(11;19)(q23;p13) . | t(11;19)(q23;p13.1) . | t(11;19)(q23;p13.3) . | t(1;11)(q21;q23) . | t(4;11)(q21;q23) . | t(10;11)(p11.2;q23) . | t(11;17)(q23;q21) . | Other . | P* . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | 756 | 328 | 98 | 35 | 31 | 34 | 25 | 25 | 13 | 12 | 12 | 143 | |
| Male sex, n (%) | 367 (48.5) | 157 (47.9) | 55 (56.1) | 19 (54.3) | 13 (41.9) | 15 (44.1) | 11 (44.0) | 9 (36.0) | 3 (23.1) | 6 (50) | 7 (58.3) | 72 (50.3) | .495 |
| Median age (N = 756) | 2.2 | 2.6 | 1.3 | 12.4 | 1.6 | 4.6 | 7.1 | 1.3 | 1.3 | 1.0 | 9.0 | 1.9 | |
| Less than 2 y, n (%) | 358 (47.4) | 137 (41.8) | 61 (62.2) | 3 (8.6) | 18 (58.1) | 14 (41.2) | 9 (36.0) | 19 (76.0) | 8 (61.5) | 9 (75.0) | 4 (33.3) | 72 (50.3) | < .001 |
| 2 to 9 y, n (%) | 227 (30.0) | 117 (35.7) | 22 (22.4) | 12 (34.3) | 8 (25.8) | 11 (32.4) | 5 (20.0) | 6 (24.0) | 2 (15.4) | 3 (25.0) | 3 (25.0) | 41 (28.6) | |
| 10 or more y, n (%) | 171 (22.6) | 74 (22.6) | 15 (15.3) | 20 (57.1) | 5 (16.1) | 9 (26.5) | 11 (44.0) | — | 3 (23.1) | — | 5 (41.7) | 30 (21.0) | |
| Median WBC (N = 754) | 20.9 | 13.7 | 10.9 | 59.8 | 76.0 | 27.0 | 17.5 | 33.4 | 20.0 | 17.2 | 87.8 | 17.2 | |
| Less than 20 × 109/L, n (%) | 371 (49.1) | 180 (54.9) | 58 (59.2) | 8 (22.9) | 10 (32.3) | 15 (44.1) | 14 (56.09) | 9 (36.0) | 6 (46.2) | 6 (50.0) | 4 (33.3) | 61 (42.7) | |
| 20 to less than 100 × 109/L, n (%) | 206 (27.2) | 82 (25.0) | 22 (22.4) | 12 (34.3) | 9 (29.0) | 13 (38.2) | 3 (12.0) | 11 (44.0) | 3 (23.1) | 2 (16.7) | 3 (25.0) | 46 (32.2) | < .001 |
| 100 or more × 109/L, n (%) | 177 (23.4) | 65 (19.8) | 18 (18.4) | 15 (42.9) | 12 (38.7) | 6 (17.6) | 8 (32.0) | 5 (20.0) | 4 (30.8) | 4 (33.3) | 5 (41.7) | 35 (24.5) | |
| FAB type, n (%) (N = 722) | < .001 | ||||||||||||
| FAB-M0 | 23 (3.2) | 3 (1.0) | 4 (4.3) | — | 1 (3.2) | 1 (3.0) | 3 (12.0) | — | 3 (25.0) | 1 (9.1) | 1 (8.3) | 6 (4.5) | |
| FAB-M1 | 40 (5.5) | 9 (2.9) | 3 (3.2) | 5 (14.7) | 1 (3.2) | 6 (18.2) | 4 (16.0) | 3 (12.0) | 1 (8.3) | 1 (9.1) | — | 7 (5.3) | |
| FAB-M2 | 33 (4.6) | 10 (3.2) | 2 (2.2) | 2 (5.9) | 2 (6.5) | 5 (15.2) | — | 2 (8.0) | — | — | 1 (8.3) | 9 (6.8) | |
| FAB-M3 | — | — | — | — | — | — | — | — | — | — | — | — | |
| FAB-M4 | 137 (19.0) | 23 (7.3) | 13 (14.0) | 12 (35.3) | 13 (41.9) | 10 (30.3) | 5 (20.0) | 14 (56.0) | 2 (16.7) | 3 (27.3) | 4 (33.3) | 38 (28.6) | |
| FAB-M5 | 462 (64.0) | 254 (81.2) | 67 (72.0) | 14 (41.2) | 14 (45.2) | 11 (33.3) | 12 (48.0) | 6 (24.0) | 5 (41.7) | 6 (54.5) | 6 (50.0) | 67 (50.4) | |
| FAB-M6 | — | — | — | — | — | — | — | — | — | — | — | — | |
| FAB-M7 | 20 (2.8) | 14 (4.5) | 3 (3.2) | — | — | — | 1 (4.0) | — | 1 (8.3) | — | — | 1 (0.8) | |
| FAB unspecified | 7 (1.0) | — | 1 (1.1) | 1 (2.9) | — | — | — | — | — | — | — | 5 (3.8) | |
| Median blast in BM (%) (N = 653) | 80.0 | 82.0 | 82.0 | 88.5 | 72.0 | 70.0 | 86.0 | 69.0 | 72.0 | 45.0 | 85.0 | 79.0 | |
| CNS involvement, n (%) (N = 693) | 100 (14.4) | 33 (11.0) | 16 (17.6) | 5 (15.2) | 8 (27.6) | 6 (19.4) | 2 (9.1) | 2 (8.0) | 1 (9.1) | 2 (22.2) | 3 (25.0) | 22 (17.1) | .272 |
| Hepatomegaly, n (%) (N = 634) | 371 (58.8) | 163 (57.0) | 55 (63.2) | 17 (63.0) | 21 (67.7) | 11 (40.7) | 10 (62.5) | 12 (57.1) | 6 (60.0) | 4 (50.0) | 7 (63.6) | 65 (59.1) | .782 |
| Splenomegaly, n (%) (N = 641) | 278 (43.4) | 123 (43.2) | 44 (50.0) | 15 (55.6) | 15 (48.4) | 9 (34.6) | 7 (43.8) | 4 (20.0) | 4 (20.0) | 5 (62.5) | 3 (27.3) | 49 (45.0) | .347 |
| Additional cytogenetic aberrations, n (%) (N = 736) | 375 (51.0) | 164 (51.4) | 42 (43.8) | 19 (54.3) | 21 (66.7) | 21 (61.8) | 12 (48.0) | 18 (75.0) | 5 (38.5) | 5 (41.7) | 8 (66.7) | 60 (44.4) | .062 |
| . | Total . | t(9;11)(p22;q23) . | t(10;11)(p12;q23) . | t(6;11)(q27;q23) . | t(11;19)(q23;p13) . | t(11;19)(q23;p13.1) . | t(11;19)(q23;p13.3) . | t(1;11)(q21;q23) . | t(4;11)(q21;q23) . | t(10;11)(p11.2;q23) . | t(11;17)(q23;q21) . | Other . | P* . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | 756 | 328 | 98 | 35 | 31 | 34 | 25 | 25 | 13 | 12 | 12 | 143 | |
| Male sex, n (%) | 367 (48.5) | 157 (47.9) | 55 (56.1) | 19 (54.3) | 13 (41.9) | 15 (44.1) | 11 (44.0) | 9 (36.0) | 3 (23.1) | 6 (50) | 7 (58.3) | 72 (50.3) | .495 |
| Median age (N = 756) | 2.2 | 2.6 | 1.3 | 12.4 | 1.6 | 4.6 | 7.1 | 1.3 | 1.3 | 1.0 | 9.0 | 1.9 | |
| Less than 2 y, n (%) | 358 (47.4) | 137 (41.8) | 61 (62.2) | 3 (8.6) | 18 (58.1) | 14 (41.2) | 9 (36.0) | 19 (76.0) | 8 (61.5) | 9 (75.0) | 4 (33.3) | 72 (50.3) | < .001 |
| 2 to 9 y, n (%) | 227 (30.0) | 117 (35.7) | 22 (22.4) | 12 (34.3) | 8 (25.8) | 11 (32.4) | 5 (20.0) | 6 (24.0) | 2 (15.4) | 3 (25.0) | 3 (25.0) | 41 (28.6) | |
| 10 or more y, n (%) | 171 (22.6) | 74 (22.6) | 15 (15.3) | 20 (57.1) | 5 (16.1) | 9 (26.5) | 11 (44.0) | — | 3 (23.1) | — | 5 (41.7) | 30 (21.0) | |
| Median WBC (N = 754) | 20.9 | 13.7 | 10.9 | 59.8 | 76.0 | 27.0 | 17.5 | 33.4 | 20.0 | 17.2 | 87.8 | 17.2 | |
| Less than 20 × 109/L, n (%) | 371 (49.1) | 180 (54.9) | 58 (59.2) | 8 (22.9) | 10 (32.3) | 15 (44.1) | 14 (56.09) | 9 (36.0) | 6 (46.2) | 6 (50.0) | 4 (33.3) | 61 (42.7) | |
| 20 to less than 100 × 109/L, n (%) | 206 (27.2) | 82 (25.0) | 22 (22.4) | 12 (34.3) | 9 (29.0) | 13 (38.2) | 3 (12.0) | 11 (44.0) | 3 (23.1) | 2 (16.7) | 3 (25.0) | 46 (32.2) | < .001 |
| 100 or more × 109/L, n (%) | 177 (23.4) | 65 (19.8) | 18 (18.4) | 15 (42.9) | 12 (38.7) | 6 (17.6) | 8 (32.0) | 5 (20.0) | 4 (30.8) | 4 (33.3) | 5 (41.7) | 35 (24.5) | |
| FAB type, n (%) (N = 722) | < .001 | ||||||||||||
| FAB-M0 | 23 (3.2) | 3 (1.0) | 4 (4.3) | — | 1 (3.2) | 1 (3.0) | 3 (12.0) | — | 3 (25.0) | 1 (9.1) | 1 (8.3) | 6 (4.5) | |
| FAB-M1 | 40 (5.5) | 9 (2.9) | 3 (3.2) | 5 (14.7) | 1 (3.2) | 6 (18.2) | 4 (16.0) | 3 (12.0) | 1 (8.3) | 1 (9.1) | — | 7 (5.3) | |
| FAB-M2 | 33 (4.6) | 10 (3.2) | 2 (2.2) | 2 (5.9) | 2 (6.5) | 5 (15.2) | — | 2 (8.0) | — | — | 1 (8.3) | 9 (6.8) | |
| FAB-M3 | — | — | — | — | — | — | — | — | — | — | — | — | |
| FAB-M4 | 137 (19.0) | 23 (7.3) | 13 (14.0) | 12 (35.3) | 13 (41.9) | 10 (30.3) | 5 (20.0) | 14 (56.0) | 2 (16.7) | 3 (27.3) | 4 (33.3) | 38 (28.6) | |
| FAB-M5 | 462 (64.0) | 254 (81.2) | 67 (72.0) | 14 (41.2) | 14 (45.2) | 11 (33.3) | 12 (48.0) | 6 (24.0) | 5 (41.7) | 6 (54.5) | 6 (50.0) | 67 (50.4) | |
| FAB-M6 | — | — | — | — | — | — | — | — | — | — | — | — | |
| FAB-M7 | 20 (2.8) | 14 (4.5) | 3 (3.2) | — | — | — | 1 (4.0) | — | 1 (8.3) | — | — | 1 (0.8) | |
| FAB unspecified | 7 (1.0) | — | 1 (1.1) | 1 (2.9) | — | — | — | — | — | — | — | 5 (3.8) | |
| Median blast in BM (%) (N = 653) | 80.0 | 82.0 | 82.0 | 88.5 | 72.0 | 70.0 | 86.0 | 69.0 | 72.0 | 45.0 | 85.0 | 79.0 | |
| CNS involvement, n (%) (N = 693) | 100 (14.4) | 33 (11.0) | 16 (17.6) | 5 (15.2) | 8 (27.6) | 6 (19.4) | 2 (9.1) | 2 (8.0) | 1 (9.1) | 2 (22.2) | 3 (25.0) | 22 (17.1) | .272 |
| Hepatomegaly, n (%) (N = 634) | 371 (58.8) | 163 (57.0) | 55 (63.2) | 17 (63.0) | 21 (67.7) | 11 (40.7) | 10 (62.5) | 12 (57.1) | 6 (60.0) | 4 (50.0) | 7 (63.6) | 65 (59.1) | .782 |
| Splenomegaly, n (%) (N = 641) | 278 (43.4) | 123 (43.2) | 44 (50.0) | 15 (55.6) | 15 (48.4) | 9 (34.6) | 7 (43.8) | 4 (20.0) | 4 (20.0) | 5 (62.5) | 3 (27.3) | 49 (45.0) | .347 |
| Additional cytogenetic aberrations, n (%) (N = 736) | 375 (51.0) | 164 (51.4) | 42 (43.8) | 19 (54.3) | 21 (66.7) | 21 (61.8) | 12 (48.0) | 18 (75.0) | 5 (38.5) | 5 (41.7) | 8 (66.7) | 60 (44.4) | .062 |
WBC indicates white blood cell count; FAB, French-American-British morphology classification; BM, bone marrow; CNS, central nervous system; and —, zero.
P values indicate whether the differences are significant among the subgroups.