Summary of updated response criteria from the Third International Workshop on Waldenstrom's Macroglobulinemia
| Response . | Criteria . |
|---|---|
| Complete response (CR) | Disappearance of monoclonal protein by immunofixation; no histologic evidence of bone marrow involvement, and resolution of any adenopathy/organomegaly (confirmed by CT scan), along with no signs or symptoms attributable to WM; reconfirmation of the CR status is required at least 6 weeks apart with a second immunofixation |
| Partial response (PR) | A > 50% reduction of serum monoclonal IgM concentration on protein electrophoresis and > 50% decrease in adenopathy/organomegaly on physical examination or on CT scan; no new symptoms or signs of active disease |
| Minor response (MR) | A > 25% but < 50% reduction of serum monoclonal IgM by protein electrophoresis; no new symptoms or signs of active disease |
| Stable disease (SD) | A < 25% reduction and < 25% increase of serum monoclonal IgM by electrophoresis without progression of adenopathy/organomegaly, cytopenias, or clinically significant symptoms resulting from disease and/or signs of WM |
| Progressive disease (PD) | A > 25% increase in serum monoclonal IgM by protein electrophoresis confirmed by a second measurement or progression of clinically significant findings resulting from disease (ie, anemia, thrombocytopenia, leukopenia, bulky adenopathy/organomegaly) or symptoms (unexplained recurrent fever > 38.4°C, drenching night sweats, > 10% body weight loss, or hyperviscosity, neuropathy, symptomatic cryoglobulinemia, or amyloidosis) attributable to WM |
| Response . | Criteria . |
|---|---|
| Complete response (CR) | Disappearance of monoclonal protein by immunofixation; no histologic evidence of bone marrow involvement, and resolution of any adenopathy/organomegaly (confirmed by CT scan), along with no signs or symptoms attributable to WM; reconfirmation of the CR status is required at least 6 weeks apart with a second immunofixation |
| Partial response (PR) | A > 50% reduction of serum monoclonal IgM concentration on protein electrophoresis and > 50% decrease in adenopathy/organomegaly on physical examination or on CT scan; no new symptoms or signs of active disease |
| Minor response (MR) | A > 25% but < 50% reduction of serum monoclonal IgM by protein electrophoresis; no new symptoms or signs of active disease |
| Stable disease (SD) | A < 25% reduction and < 25% increase of serum monoclonal IgM by electrophoresis without progression of adenopathy/organomegaly, cytopenias, or clinically significant symptoms resulting from disease and/or signs of WM |
| Progressive disease (PD) | A > 25% increase in serum monoclonal IgM by protein electrophoresis confirmed by a second measurement or progression of clinically significant findings resulting from disease (ie, anemia, thrombocytopenia, leukopenia, bulky adenopathy/organomegaly) or symptoms (unexplained recurrent fever > 38.4°C, drenching night sweats, > 10% body weight loss, or hyperviscosity, neuropathy, symptomatic cryoglobulinemia, or amyloidosis) attributable to WM |
Data from Kimby et al.32