Table 1

Quantitative, multi-item measures commonly used to assess QOL in HCT patients

Measure nameAbbreviationPurposeDomains assessedNo. of itemsValidation sample(s)Reliability
City of Hope/Stanford Longterm BMT Survivor Index84  BMT-SS, COH-QOL HCT-specific QOL Subscales: Productive activity and functioning, health status and treatment-related physical symptoms, qualitative aspects of daily life 33 items assessed via interview HCT patients — 
Cancer Rehabilitation Evaluation System–Short Form85  CARES-SF, CIP General measure of QOL in cancer Subscales: Physical, psychosocial, sexual, marital, medical interaction; Global CARES 139 items in Likert scale format Patients with heterogeneous cancer diagnoses Test-retest: .82-.9185  
European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire86  EORTC QLQ-C30 General measure of QOL in cancer Functioning scales: physical, social, role, cognitive, emotional; Symptom scales: fatigue, pain, nausea/vomiting; Global health/QOL scale 30 items in yes/no or Likert scale format Nonresectable lung cancer Cronbach alpha: .54-.8686  
European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire–Leukemia module35,87  EORTC QLQ-LEU, EORTC QLQ-LEU-BMT Leukemia-specific QOL Subscales: GVHD, infection 32 items in Likert scale format Acute myelogenous leukemia Cronbach alpha: .71-.7987  
Functional Assessment of Cancer Therapy–General88  FACT-G General measure of QOL in cancer Subscales: physical, functional, social, emotional, relationship with doctor; Total score 28 items in Likert scale format Patients with heterogeneous cancer diagnoses Cronbach alpha: .65-.8988 ; 3-7 d test-retest: .82-.9288  
Functional Assessment of Cancer Therapy–Bone Marrow Transplant Module34  FACT-BMT HCT-specific QOL FACT-G;BMT subscale (BMTS); Trial Outcome Index (TOI): sum of physical, functional, BMTS subscales 47 items in Likert scale format HCT patients Cronbach alpha at discharge: .52-.8534  
Functional Living Index–Cancer89  FLIC General measure of QOL Subscales: physical, psychologic, social, current well-being, gastrointestinal symptoms; Total score 22 items in visual analogue scale Patients with heterogeneous cancer diagnoses Cronbach alpha: .65-.8789  
cGVHD Symptom Scale7  — Measure of symptoms of cGVHD Subscales: energy, skin, nutrition, lung, psychologic, eye, mouth; Overall 30 items in Likert scale format HCT patients Cronbach alpha: .79-.857 ; Test-retest: .28-.937  
Medical Outcomes Study Short Form–3690,91  SF-36 General measure of QOL in healthy and patient populations Subscales: physical functioning, role–physical, bodily pain, general health, vitality, social functioning, role–emotional, mental health; Composite scores: physical, mental 36 items in yes/no or Likert scale format General US population, cardiac patients, chronic pain, diabetes, depression Cronbach alpha: .63-.9490,91  
Medical Outcomes Study Short Form–1292  SF-12 General measure of QOL in healthy and patient populations Composite scores: physical, mental 12 items in yes/no or Likert scale format General US population Two week test-retest: .76, .8992  
Nottingham Health Profile93  NHP General measure of QOL in healthy and patient populations Subscales: energy level, pain, emotional reaction, sleep, social isolation, physical abilities 38 items in yes/no format Medical patients, healthy individuals Four week test-retest: .77-.8593  
Quality of Life Index94  QLI General measure of QOL in patient populations Total score 5 items in Likert scale format assessed by physician Medical patients Cronbach alpha: .7894  
Satisfaction with Life Domains Scale–Cancer95  SLDS-C Measure of satisfaction with QOL Total score 18 items, patients select one of 7 faces for each item to indicate their satisfaction HCT patients Cronbach alpha: .9395  
Schedule for the Evaluation of the Individual Quality of Life96  SEIQOL, SEIQOL-DW General measure of QOL in healthy and patient populations Total score: patients nominate 5 most important areas of quality of life, evaluate their functioning and relative importance of each area, evaluations summed N/A Advanced cancer, HIV/AIDS, older adults — 
Sickness Impact Profile97  SIP General measure of QOL in patient populations Categories: social interaction, ambulation, sleep and rest, nutrition, daily work, household management, mobility and confinement, movement of the body, communication activity, interaction with family members, emotions, personal hygiene; Dimensions: physical, psychosocial Overall SIP 136 items in Likert scale format Medical patients Cronbach alpha: .8197  
Measure nameAbbreviationPurposeDomains assessedNo. of itemsValidation sample(s)Reliability
City of Hope/Stanford Longterm BMT Survivor Index84  BMT-SS, COH-QOL HCT-specific QOL Subscales: Productive activity and functioning, health status and treatment-related physical symptoms, qualitative aspects of daily life 33 items assessed via interview HCT patients — 
Cancer Rehabilitation Evaluation System–Short Form85  CARES-SF, CIP General measure of QOL in cancer Subscales: Physical, psychosocial, sexual, marital, medical interaction; Global CARES 139 items in Likert scale format Patients with heterogeneous cancer diagnoses Test-retest: .82-.9185  
European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire86  EORTC QLQ-C30 General measure of QOL in cancer Functioning scales: physical, social, role, cognitive, emotional; Symptom scales: fatigue, pain, nausea/vomiting; Global health/QOL scale 30 items in yes/no or Likert scale format Nonresectable lung cancer Cronbach alpha: .54-.8686  
European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire–Leukemia module35,87  EORTC QLQ-LEU, EORTC QLQ-LEU-BMT Leukemia-specific QOL Subscales: GVHD, infection 32 items in Likert scale format Acute myelogenous leukemia Cronbach alpha: .71-.7987  
Functional Assessment of Cancer Therapy–General88  FACT-G General measure of QOL in cancer Subscales: physical, functional, social, emotional, relationship with doctor; Total score 28 items in Likert scale format Patients with heterogeneous cancer diagnoses Cronbach alpha: .65-.8988 ; 3-7 d test-retest: .82-.9288  
Functional Assessment of Cancer Therapy–Bone Marrow Transplant Module34  FACT-BMT HCT-specific QOL FACT-G;BMT subscale (BMTS); Trial Outcome Index (TOI): sum of physical, functional, BMTS subscales 47 items in Likert scale format HCT patients Cronbach alpha at discharge: .52-.8534  
Functional Living Index–Cancer89  FLIC General measure of QOL Subscales: physical, psychologic, social, current well-being, gastrointestinal symptoms; Total score 22 items in visual analogue scale Patients with heterogeneous cancer diagnoses Cronbach alpha: .65-.8789  
cGVHD Symptom Scale7  — Measure of symptoms of cGVHD Subscales: energy, skin, nutrition, lung, psychologic, eye, mouth; Overall 30 items in Likert scale format HCT patients Cronbach alpha: .79-.857 ; Test-retest: .28-.937  
Medical Outcomes Study Short Form–3690,91  SF-36 General measure of QOL in healthy and patient populations Subscales: physical functioning, role–physical, bodily pain, general health, vitality, social functioning, role–emotional, mental health; Composite scores: physical, mental 36 items in yes/no or Likert scale format General US population, cardiac patients, chronic pain, diabetes, depression Cronbach alpha: .63-.9490,91  
Medical Outcomes Study Short Form–1292  SF-12 General measure of QOL in healthy and patient populations Composite scores: physical, mental 12 items in yes/no or Likert scale format General US population Two week test-retest: .76, .8992  
Nottingham Health Profile93  NHP General measure of QOL in healthy and patient populations Subscales: energy level, pain, emotional reaction, sleep, social isolation, physical abilities 38 items in yes/no format Medical patients, healthy individuals Four week test-retest: .77-.8593  
Quality of Life Index94  QLI General measure of QOL in patient populations Total score 5 items in Likert scale format assessed by physician Medical patients Cronbach alpha: .7894  
Satisfaction with Life Domains Scale–Cancer95  SLDS-C Measure of satisfaction with QOL Total score 18 items, patients select one of 7 faces for each item to indicate their satisfaction HCT patients Cronbach alpha: .9395  
Schedule for the Evaluation of the Individual Quality of Life96  SEIQOL, SEIQOL-DW General measure of QOL in healthy and patient populations Total score: patients nominate 5 most important areas of quality of life, evaluate their functioning and relative importance of each area, evaluations summed N/A Advanced cancer, HIV/AIDS, older adults — 
Sickness Impact Profile97  SIP General measure of QOL in patient populations Categories: social interaction, ambulation, sleep and rest, nutrition, daily work, household management, mobility and confinement, movement of the body, communication activity, interaction with family members, emotions, personal hygiene; Dimensions: physical, psychosocial Overall SIP 136 items in Likert scale format Medical patients Cronbach alpha: .8197  
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