Multivariate Cox regression analyses of baseline laboratory and imaging parameters and FDG suppression prior to first transplantation associated with overall and event-free survival without and with gene array–derived parameters
| Model . | n/N (%) . | Overall survival from first transplantation . | Event-free survival from first transplantation . | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P* . | Cumulative R2, percentage† . | HR (95% CI) . | P* . | Cumulative R2, percentage† . | ||
| Multivariate without gene array data | |||||||
| 100% PET-FL reduction | 140/196 (71) | 0.33 (0.17-0.64) | .001 | 37.1 | 0.47 (0.26-0.85) | .013 | 48.1 |
| PET-FL > 3 | 69/196 (35) | NS | NS | NS | 2.01 (1.08-3.76) | .028 | 36.9 |
| LDH ≥ 190 U/L | 46/196 (23) | 2.27 (1.11-4.65) | .024 | 43.0 | 2.61 (1.42-4.81) | .002 | 24.8 |
| B2M > 5.5 mg/L | 37/196 (19) | 2.45 (1.19-5.02) | .015 | 48.6 | 2.00 (1.06-3.79) | .033 | 43.3 |
| Multivariate with gene array data | |||||||
| 100% PET-FL reduction | 126/175 (72) | 0.41 (0.20-0.86) | .017 | 37.1 | 0.51 (0.27-0.96) | .038 | 56.2 |
| GEP high-risk | 28/175 (16) | 2.64 (1.21-5.80) | .015 | 51.8 | 2.12 (1.07-4.23) | .032 | 48.1 |
| Cytogenetic abnormalities | 62/175 (35) | 2.59 (1.18-5.72) | .018 | 58.5 | NS | NS | NS |
| CRP ≥ 8 mg/L | 57/175 (33) | 2.43 (1.17-5.05) | .018 | 57.0 | NS | NS | NS |
| Model . | n/N (%) . | Overall survival from first transplantation . | Event-free survival from first transplantation . | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P* . | Cumulative R2, percentage† . | HR (95% CI) . | P* . | Cumulative R2, percentage† . | ||
| Multivariate without gene array data | |||||||
| 100% PET-FL reduction | 140/196 (71) | 0.33 (0.17-0.64) | .001 | 37.1 | 0.47 (0.26-0.85) | .013 | 48.1 |
| PET-FL > 3 | 69/196 (35) | NS | NS | NS | 2.01 (1.08-3.76) | .028 | 36.9 |
| LDH ≥ 190 U/L | 46/196 (23) | 2.27 (1.11-4.65) | .024 | 43.0 | 2.61 (1.42-4.81) | .002 | 24.8 |
| B2M > 5.5 mg/L | 37/196 (19) | 2.45 (1.19-5.02) | .015 | 48.6 | 2.00 (1.06-3.79) | .033 | 43.3 |
| Multivariate with gene array data | |||||||
| 100% PET-FL reduction | 126/175 (72) | 0.41 (0.20-0.86) | .017 | 37.1 | 0.51 (0.27-0.96) | .038 | 56.2 |
| GEP high-risk | 28/175 (16) | 2.64 (1.21-5.80) | .015 | 51.8 | 2.12 (1.07-4.23) | .032 | 48.1 |
| Cytogenetic abnormalities | 62/175 (35) | 2.59 (1.18-5.72) | .018 | 58.5 | NS | NS | NS |
| CRP ≥ 8 mg/L | 57/175 (33) | 2.43 (1.17-5.05) | .018 | 57.0 | NS | NS | NS |
HR indicates hazard ratio; CI, confidence interval; and NS, not statistically significant at the .05 level.
P value from Wald χ2 test in Cox regression. Multivariate model uses stepwise selection with entry level .1 and variable remains if it meets the .05 level. Variables considered for stepwise selection include albumin, beta-2-microglobulin (B2M), hemoglobin (Hb), lactate dehydrogenase (LDH), C-reactive protein (CRP), cytogenetic abnormalities (CA), and gene expression profiling (GEP) high-risk; imaging parameters include MRI-FL, MBS-OL, PET-FL, SUV-FL, and EMD. Variables considered for stepwise selection overall survival include B2M, Hb, LDH, CRP, CA, MRI-FL, MBS-OL, PET-FL, SUV-FL, EMD, PET-FL reduction, CR by first transplantation, and nCR by first transplantation. Variables considered for stepwise selection event-free survival include B2M, creatinine, Hb, LDH, CRP, CA, MRI-FL, MBS-OL, PET-FL, SUV-FL, EMD, PET-FL reduction, CR by first transplantation, and n-CR by first transplantation.
Variable with smallest R2 is first to enter model; the next smallest is second to enter. The largest R2 is last to enter.