Univariate and multivariate logistic regression analyses of baseline laboratory and imaging parameters associated with the presence of more than 3 FDG-avid focal lesions (PET-FL > 3)
| Variable . | N . | With factor, n (%) . | Without factor, n (%) . | OR (95% CI) . | P* . |
|---|---|---|---|---|---|
| Univariate model | |||||
| B2M ≥ 3.5 mg/L | 239 | 46/108 (43) | 36/131 (27) | 1.96 (1.14-3.36) | .015 |
| B2M > 5.5 mg/L | 239 | 25/52 (48) | 57/187 (30) | 2.11 (1.13-3.95) | .019 |
| LDH ≥ 190 U/L | 239 | 27/56 (48) | 55/183 (30) | 2.17 (1.17-4.00) | .013 |
| CRP ≥ 8 mg/L | 238 | 38/79 (48) | 43/159 (27) | 2.50 (1.42-4.39) | .001 |
| GEP high-risk | 216 | 19/32 (59) | 55/184 (30) | 3.43 (1.58-7.42) | .002 |
| GEP LB subgroup | 216 | 2/27 (7) | 72/189 (38) | 0.13 (0.03-0.57) | .006 |
| GEP PR subgroup | 216 | 11/18 (61) | 63/198 (32) | 3.37 (1.25-9.10) | .017 |
| GEP proliferation index ≥ 10 | 216 | 14/23 (61) | 60/193 (31) | 3.45 (1.41-8.41) | .006 |
| MRI-FL > 7 | 239 | 44/68 (65) | 38/171 (22) | 6.42 (3.47-11.86) | < .001 |
| MBS-OL > 2 | 239 | 42/75 (56) | 40/164 (24) | 3.95 (2.21-7.04) | < .001 |
| Multivariate model | |||||
| CRP ≥ 8 mg/L | 215 | 34/71 (48) | 39/144 (27) | 1.98 (1.02-3.84) | .045 |
| GEP LB subgroup | 215 | 2/27 (7) | 71/188 (38) | 0.14 (0.03-0.65) | .012 |
| MRI-FL > 7 | 215 | 37/58 (64) | 36/157 (23) | 4.09 (2.01-8.32) | < .001 |
| MBS-OL > 2 | 215 | 35/66 (53) | 38/149 (26) | 2.32 (1.16-4.65) | .017 |
| Variable . | N . | With factor, n (%) . | Without factor, n (%) . | OR (95% CI) . | P* . |
|---|---|---|---|---|---|
| Univariate model | |||||
| B2M ≥ 3.5 mg/L | 239 | 46/108 (43) | 36/131 (27) | 1.96 (1.14-3.36) | .015 |
| B2M > 5.5 mg/L | 239 | 25/52 (48) | 57/187 (30) | 2.11 (1.13-3.95) | .019 |
| LDH ≥ 190 U/L | 239 | 27/56 (48) | 55/183 (30) | 2.17 (1.17-4.00) | .013 |
| CRP ≥ 8 mg/L | 238 | 38/79 (48) | 43/159 (27) | 2.50 (1.42-4.39) | .001 |
| GEP high-risk | 216 | 19/32 (59) | 55/184 (30) | 3.43 (1.58-7.42) | .002 |
| GEP LB subgroup | 216 | 2/27 (7) | 72/189 (38) | 0.13 (0.03-0.57) | .006 |
| GEP PR subgroup | 216 | 11/18 (61) | 63/198 (32) | 3.37 (1.25-9.10) | .017 |
| GEP proliferation index ≥ 10 | 216 | 14/23 (61) | 60/193 (31) | 3.45 (1.41-8.41) | .006 |
| MRI-FL > 7 | 239 | 44/68 (65) | 38/171 (22) | 6.42 (3.47-11.86) | < .001 |
| MBS-OL > 2 | 239 | 42/75 (56) | 40/164 (24) | 3.95 (2.21-7.04) | < .001 |
| Multivariate model | |||||
| CRP ≥ 8 mg/L | 215 | 34/71 (48) | 39/144 (27) | 1.98 (1.02-3.84) | .045 |
| GEP LB subgroup | 215 | 2/27 (7) | 71/188 (38) | 0.14 (0.03-0.65) | .012 |
| MRI-FL > 7 | 215 | 37/58 (64) | 36/157 (23) | 4.09 (2.01-8.32) | < .001 |
| MBS-OL > 2 | 215 | 35/66 (53) | 38/149 (26) | 2.32 (1.16-4.65) | .017 |
OR indicates odds ratio; CI, confidence interval; B2M, β-2-microglobulin; LDH, lactate dehydrogenase; CRP, C-reactive protein; GEP, gene expression profiling; LB, low bone disease; PR, proliferation; FL, focal lesion; and OL, osteolytic lesion.
P value from Wald χ2 test in logistic regression. NS2: Multivariate results not statistically significant at the .05 level. Univariate P values reported regardless of significance. Multivariate model uses stepwise selection with entry level .1, and variable remains if it meets the .05 level. A multivariate P > .05 indicates variable forced into model with significant variables chosen using stepwise selection. Other nonsignificant univariate variables include age, albumin, creatinine, hemoglobin, cytogenetic abnormalities, GEP-defined molecular subgroups CD-1, CD-2, HY, MF, MS, MY, and TP53 deletion.