Frequency of somatic CNAs in 14 E/R-positive cases at diagnosis and relapse
| Patient ID . | CNAs . | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Losses . | Gains . | All . | |||||||
| Diagnosis . | Relapse . | Shared . | Diagnosis . | Relapse . | Shared . | Diagnosis . | Relapse . | Shared . | |
| 1 | 4 | 7 | 0 | 2 | 2 | 1 | 6 | 9 | 1 |
| 2 | 6 | 12 (1) | 6 | 0 | 0 | 0 | 6 | 12 (1) | 6 |
| 3 | 7 | 6 | 6 | 0 | 2 | 0 | 7 | 8 | 6 |
| 4 | 4 | 9 | 3 | 0 | 0 | 0 | 4 | 9 | 3 |
| 5 | 1 | 7 (1) | 0 | 2 | 1 | 0 | 3 | 8 (1) | 0 |
| 6 | 6 | 10 (1) | 6 | 2 | 3 | 2 | 8 | 13 (1) | 8 |
| 7 | 3 | 5 | 2 | 0 | 1 | 0 | 3 | 6 | 2 |
| 8 | 7 (1) | 9 | 5 | 0 | 1 | 0 | 7 (1) | 10 | 5 |
| 9 | 10 | 11 | 7 | 0 | 1 | 0 | 10 | 12 | 7 |
| 10 | 14 (1) | 13 | 10 | 1 | 7 | 0 | 15 (1) | 20 | 10 |
| 11 | 8 (1) | 8 (1) | 2 (1) | 1 | 0 | 0 | 9 (1) | 8 (1) | 2 (1) |
| 12 | 3 | 14 (1) | 2 | 0 | 0 | 0 | 3 | 14 (1) | 2 |
| 13 | 10 (1) | 18 (1) | 10* (1) | 2 | 2 | 2 | 12 (1) | 20 (1) | 13 (1) |
| 14 | 9 | 16 (3) | 8 | 3 | 10 | 2 | 12 | 26 (3) | 10 |
| Total | 92 (4) | 145 (9) | 67 (2) | 13 | 30 | 7 | 105 (4) | 175 (9) | 74 (2) |
| Mean | 6.6 | 10.4 | 4.8 | 0.9 | 2.1 | 0.5 | 7.5 | 12.5 | 5.3 |
| Patient ID . | CNAs . | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Losses . | Gains . | All . | |||||||
| Diagnosis . | Relapse . | Shared . | Diagnosis . | Relapse . | Shared . | Diagnosis . | Relapse . | Shared . | |
| 1 | 4 | 7 | 0 | 2 | 2 | 1 | 6 | 9 | 1 |
| 2 | 6 | 12 (1) | 6 | 0 | 0 | 0 | 6 | 12 (1) | 6 |
| 3 | 7 | 6 | 6 | 0 | 2 | 0 | 7 | 8 | 6 |
| 4 | 4 | 9 | 3 | 0 | 0 | 0 | 4 | 9 | 3 |
| 5 | 1 | 7 (1) | 0 | 2 | 1 | 0 | 3 | 8 (1) | 0 |
| 6 | 6 | 10 (1) | 6 | 2 | 3 | 2 | 8 | 13 (1) | 8 |
| 7 | 3 | 5 | 2 | 0 | 1 | 0 | 3 | 6 | 2 |
| 8 | 7 (1) | 9 | 5 | 0 | 1 | 0 | 7 (1) | 10 | 5 |
| 9 | 10 | 11 | 7 | 0 | 1 | 0 | 10 | 12 | 7 |
| 10 | 14 (1) | 13 | 10 | 1 | 7 | 0 | 15 (1) | 20 | 10 |
| 11 | 8 (1) | 8 (1) | 2 (1) | 1 | 0 | 0 | 9 (1) | 8 (1) | 2 (1) |
| 12 | 3 | 14 (1) | 2 | 0 | 0 | 0 | 3 | 14 (1) | 2 |
| 13 | 10 (1) | 18 (1) | 10* (1) | 2 | 2 | 2 | 12 (1) | 20 (1) | 13 (1) |
| 14 | 9 | 16 (3) | 8 | 3 | 10 | 2 | 12 | 26 (3) | 10 |
| Total | 92 (4) | 145 (9) | 67 (2) | 13 | 30 | 7 | 105 (4) | 175 (9) | 74 (2) |
| Mean | 6.6 | 10.4 | 4.8 | 0.9 | 2.1 | 0.5 | 7.5 | 12.5 | 5.3 |
Included are only cases with available remission samples. Indicated are all CNAs in the respective leukemia; in case of biallelic deletions, the number is given in parentheses.
For simplicity reasons, 2 deletions at relapse overlapping with 1 deletion at diagnosis were counted as 1 deletion (details about the affected regions can be found in supplemental Tables 1 and 5).