Induction of telomerase activity by methyltrienolone (R1881) in lymphocytes of TERT-mutation carriers
| . | Relative telomerase activity R1881 concentration . | |
|---|---|---|
| 0 . | 5 μM . | |
| Carriers* (n = 3) | 53% ± 4.8% | 107% ± 3.7%† |
| Noncarriers (n = 3) | 100% ± 21%* | 222% ± 26%† |
| . | Relative telomerase activity R1881 concentration . | |
|---|---|---|
| 0 . | 5 μM . | |
| Carriers* (n = 3) | 53% ± 4.8% | 107% ± 3.7%† |
| Noncarriers (n = 3) | 100% ± 21%* | 222% ± 26%† |
Telomerase activity of cultured lymphocytes is expressed as relative telomerase activity (considering telomerase activity from noncarriers' lymphocytes in the absence of hormones as reference activity).
Two clinically healthy individuals with codon Ala202Thr and one with codon Val1090Met mutations were studied; all carriers were clinically healthy and were relatives of patients with aplastic anemia with TERT mutations.
P< .01.