Characteristics of selected late-stage B-cell lymphomas
| Lymphoma . | CD19 . | PNAhigh . | IgM . | JH gene usage . | SHM, no. . | SHM percentage . |
|---|---|---|---|---|---|---|
| 1 | + | + | − | JH3 | 23/691 | 3.3 |
| 2 | + | + | − | JH1 | 18/346 | 5.2 |
| 3 | + | + | + | JH4 | 0/574 | 0.0 |
| 4 | + | − | + | JH2 | 0/502 | 0.0 |
| 5 | + | + | + | JH2 | 42/502 | 8.4 |
| Lymphoma . | CD19 . | PNAhigh . | IgM . | JH gene usage . | SHM, no. . | SHM percentage . |
|---|---|---|---|---|---|---|
| 1 | + | + | − | JH3 | 23/691 | 3.3 |
| 2 | + | + | − | JH1 | 18/346 | 5.2 |
| 3 | + | + | + | JH4 | 0/574 | 0.0 |
| 4 | + | − | + | JH2 | 0/502 | 0.0 |
| 5 | + | + | + | JH2 | 42/502 | 8.4 |
Lymphomas are identical to those analyzed for JH gene segment usage and clonality in Figure 1. Diagnosis for CD19, PNA, and IgM was performed by flow cytometry. Occurrence of SHM in the Ig locus is stated as number of mutated nucleotides per number of nucleotides sequenced and as percentage calculated from these numbers.
PNA indicates peanut agglutinin; IgM, immunoglobulin M; and SHM, somatic hypermutation.