Table 1

Two-point linkage analysis of chromosome 10 microsatellite markers and SNPs

Marker nameRutgers positionBuild 36.1 positionNo. of QPD family members genotypedLOD score at φ (recombination fraction)
0.000.010.050.10.2
D10S1453*  6 615 628 41 −∞ −16.04 −7.74 −4.26 −1.35 
D10S189* 19.62 6 761 879 41 −∞ −4.69 −2.98 −2.11 −1.05 
D10S2325* 31.35 12 832 951 41 −∞ −2.52 0.07 0.93 1.23 
D10S1423* 44.78 19 477 909 41 −∞ −2.98 0.09 1.06 1.46 
D10S1426 57.44 30 535 790 41 −∞ −1.99 1.05 1.94 2.12 
D10S1208* 62.04 35 297 637 41 −∞ −5.2 −0.25 1.33 1.97 
D10S1221*  57 199 892 41 −∞ −10.04 −4.71 -2.6 −0.83 
D10S1225 80.04 64 425 004 41 −∞ −0.92 0.31 0.65 0.66 
GATA121A08† 85.32 70 182 554 138 −∞ 4.39 4.55 4.17 3.14 
rs12356915*  73 931 323 138 −2.41 −2.15 −1.14 −0.66 −0.28 
D10S1432† 93.7 74 329 402 138 −∞ 4.69 6.65 6.75 5.56 
D10S188† 93.7 75 075 749 138 −∞ 2.98 3.23 2.95 2.11 
D10S1737† 93.7 75 259 301 138 −∞ 1.06 3.75 4.2 3.42 
QPD-1†  75 327 173 138 11.79 11.59 10.71 9.5 6.8 
PLAU  75 340 896       
rs4065 93.7 75 346 470 138 0.76 0.72 0.59 0.45 0.23 
rs1908339†  75 513 106 138 2.88 3.0 3.0 2.72 1.97 
D10S535† 93.7 76 010 712 138 −∞ 1.64 3.15 3.31 2.69 
rs7899137†  76 338 468 138 3.0 2.86 2.58 2.27 1.62 
D10S556 94.38 76 922 909 138 −∞ 1.38 2.33 2.37 1.81 
D10S195* 94.38 77 289 176 138 −∞ −3.38 −1.02 −0.15 0.4 
D10S1136† 95.77 78 009 813 138 −∞ 7.83 8.42 7.94 6.17 
D10S1730 96.85 78 600 935 41 0 −0.4 1.69 2.03 1.86 
D10S2327* 98.55 80 382 014 41 −11.38 −3.88 −1.49 −0.56 0.06 
D10S1419  92 354 576 41 −∞ −1.3 −0.06 0.32 0.43 
D10S677* 114.71 95 954 428 41 −∞ −8.1 −2.33 −0.29 0.98 
D10S1239* 121.96 103 186 224 41 −∞ −3.5 −0.51 0.44 0.87 
D10S1237 133.64 116 109 968 41 −∞ 1.04 2.09 2.22 1.83 
D10S1230* 145.08 122 732 623 41 −∞ −13.29 −6.56 −3.9 −1.59 
D10S1213 150.11 125 396 627 41 0.26 0.24 0.15 0.06 −0.02 
D10S1248* 166.09 130 982 451 41 −∞ −7.09 −3.82 −2.06 −0.53 
D10S212* 174.19 134 299 489 41 −8.49 −2.61 −0.27 0.51 0.85 
Marker nameRutgers positionBuild 36.1 positionNo. of QPD family members genotypedLOD score at φ (recombination fraction)
0.000.010.050.10.2
D10S1453*  6 615 628 41 −∞ −16.04 −7.74 −4.26 −1.35 
D10S189* 19.62 6 761 879 41 −∞ −4.69 −2.98 −2.11 −1.05 
D10S2325* 31.35 12 832 951 41 −∞ −2.52 0.07 0.93 1.23 
D10S1423* 44.78 19 477 909 41 −∞ −2.98 0.09 1.06 1.46 
D10S1426 57.44 30 535 790 41 −∞ −1.99 1.05 1.94 2.12 
D10S1208* 62.04 35 297 637 41 −∞ −5.2 −0.25 1.33 1.97 
D10S1221*  57 199 892 41 −∞ −10.04 −4.71 -2.6 −0.83 
D10S1225 80.04 64 425 004 41 −∞ −0.92 0.31 0.65 0.66 
GATA121A08† 85.32 70 182 554 138 −∞ 4.39 4.55 4.17 3.14 
rs12356915*  73 931 323 138 −2.41 −2.15 −1.14 −0.66 −0.28 
D10S1432† 93.7 74 329 402 138 −∞ 4.69 6.65 6.75 5.56 
D10S188† 93.7 75 075 749 138 −∞ 2.98 3.23 2.95 2.11 
D10S1737† 93.7 75 259 301 138 −∞ 1.06 3.75 4.2 3.42 
QPD-1†  75 327 173 138 11.79 11.59 10.71 9.5 6.8 
PLAU  75 340 896       
rs4065 93.7 75 346 470 138 0.76 0.72 0.59 0.45 0.23 
rs1908339†  75 513 106 138 2.88 3.0 3.0 2.72 1.97 
D10S535† 93.7 76 010 712 138 −∞ 1.64 3.15 3.31 2.69 
rs7899137†  76 338 468 138 3.0 2.86 2.58 2.27 1.62 
D10S556 94.38 76 922 909 138 −∞ 1.38 2.33 2.37 1.81 
D10S195* 94.38 77 289 176 138 −∞ −3.38 −1.02 −0.15 0.4 
D10S1136† 95.77 78 009 813 138 −∞ 7.83 8.42 7.94 6.17 
D10S1730 96.85 78 600 935 41 0 −0.4 1.69 2.03 1.86 
D10S2327* 98.55 80 382 014 41 −11.38 −3.88 −1.49 −0.56 0.06 
D10S1419  92 354 576 41 −∞ −1.3 −0.06 0.32 0.43 
D10S677* 114.71 95 954 428 41 −∞ −8.1 −2.33 −0.29 0.98 
D10S1239* 121.96 103 186 224 41 −∞ −3.5 −0.51 0.44 0.87 
D10S1237 133.64 116 109 968 41 −∞ 1.04 2.09 2.22 1.83 
D10S1230* 145.08 122 732 623 41 −∞ −13.29 −6.56 −3.9 −1.59 
D10S1213 150.11 125 396 627 41 0.26 0.24 0.15 0.06 −0.02 
D10S1248* 166.09 130 982 451 41 −∞ −7.09 −3.82 −2.06 −0.53 
D10S212* 174.19 134 299 489 41 −8.49 −2.61 −0.27 0.51 0.85 

Markers were evaluated for 41 selected individuals or all 138 QPD family members, as indicated. SNPs are designated by rs numbers, except for the newly identified SNP, QPD-1. PLAU indicates the location of the urokinase plasminogen activator gene. Rutgers map positions are in centimorgans, except for 6 markers whose genetic map positions are unknown. Build 36.1 positions indicate physical distances on chromosome 10.

*

Markers excluding linkage.

†

Markers giving the best evidence for linkage.

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