Table 2 Adverse events by grade and dose... | American Society of Hematology

Table 2

Adverse events by grade and dose level

Dose level, mg/kg	Toxicity grade
Dose level, mg/kg	1	2	3	4
0.1	Pharyngitis, eyelid blisters, tachycardia, dizziness, headache	Leucocytosis, diarrhea, shoulder pain, bronchitis (2), vaginosis	Arthritis*, pneumonitis
0.33	Palpitations, chest pain, diarrhea (2), nausea, cough	Blurring of vision, abdominal pain/constipation, hypercalcemia, hyperglycemia, knee swelling	Anemia, thrombocytopenia, pneumonia, neutropenia/fever	Infection, hip fracture
0.66	Hypothyroidism, elevated AST, hyperglycemia, acute GVHD (skin)	Hyperthyroidism*, cellulitis, bone pain, cough, pneumonia (2)	Anemia
1.0	Anemia, thrombocytopenia, elevated ALT/AST, elevated alkaline phosphatase	Hypotension, urinary retention	Elevated AST/ALT	Neutropenia (transient)*
3.0	Chills, fatigue (2), fever (2), night sweats, anemia, thrombocytopenia, petichiae, skin dryness, rash, hypercalcemia, hypocalcemia, hypokalemia, hypernatremia, hyponatremia, muscle cramps, dizziness (2), headache, insomnia, photophobia, colitis, diarrhea, elevated alk. phos., elevated AST/ALT, nausea (2), vomiting, increased creatinine, vaginosis, pharyngitis, agitation	Fatigue (2), Fever (2 + 1), sweats, insomnia, pruritis, rash/desquamation, abdominal pain, backache, arthritis, headache, sensory neuropathy, cough, dyspnea, pneumonia, anxiety	Leucocytosis, fever, neutropenic fever, dyspnea, mucositis	Pneumonitis*

Dose level, mg/kg	Toxicity grade
Dose level, mg/kg	1	2	3	4
0.1	Pharyngitis, eyelid blisters, tachycardia, dizziness, headache	Leucocytosis, diarrhea, shoulder pain, bronchitis (2), vaginosis	Arthritis*, pneumonitis
0.33	Palpitations, chest pain, diarrhea (2), nausea, cough	Blurring of vision, abdominal pain/constipation, hypercalcemia, hyperglycemia, knee swelling	Anemia, thrombocytopenia, pneumonia, neutropenia/fever	Infection, hip fracture
0.66	Hypothyroidism, elevated AST, hyperglycemia, acute GVHD (skin)	Hyperthyroidism*, cellulitis, bone pain, cough, pneumonia (2)	Anemia
1.0	Anemia, thrombocytopenia, elevated ALT/AST, elevated alkaline phosphatase	Hypotension, urinary retention	Elevated AST/ALT	Neutropenia (transient)*
3.0	Chills, fatigue (2), fever (2), night sweats, anemia, thrombocytopenia, petichiae, skin dryness, rash, hypercalcemia, hypocalcemia, hypokalemia, hypernatremia, hyponatremia, muscle cramps, dizziness (2), headache, insomnia, photophobia, colitis, diarrhea, elevated alk. phos., elevated AST/ALT, nausea (2), vomiting, increased creatinine, vaginosis, pharyngitis, agitation	Fatigue (2), Fever (2 + 1), sweats, insomnia, pruritis, rash/desquamation, abdominal pain, backache, arthritis, headache, sensory neuropathy, cough, dyspnea, pneumonia, anxiety	Leucocytosis, fever, neutropenic fever, dyspnea, mucositis	Pneumonitis*

Events that the investigator felt were at least possibly related to ipilimumab.