Occurrence of the KPxR motif in the Env sequences of infectious retroviruses
| Retrovirus . | Sequences* . | Occurrence, percentage . | Motif type (no.) . | Motif position† . | |
|---|---|---|---|---|---|
| Total no. . | No. containing KPxR . | ||||
| δ retrovirus | |||||
| HTLV-1 | 255 | 254 | 99.6 | KPnR (246)KPyR (7)KPsR (1) | 91-94 (SU)91-94 (SU)91-94 (SU) |
| HTLV-2 | 15 | 14 | 93.3 | KPnR (14) | 87-90 (SU) |
| HTLV-3 | 2 | 2 | 100 | KPnR (1)KPdR (1) | 91-94 (SU)91-94 (SU) |
| STLV-1 | 33 | 32 | 97 | KPnR (32) | 91-94 (SU) |
| STLV-2 | 2 | 2 | 100 | KPnR (2) | 87-90 (SU) |
| STLV-3 | 4 | 4 | 100 | KPnR (4) | 89-92 (SU) |
| Baboon TLV | 1 | 1 | 100 | KPnR (1) | 91-94 (SU) |
| BLV | 113 | 0 | 0 | ||
| Lentivirus | |||||
| HIV-1 | 71364 | 345 | 0.5 | KPvRKPiRKPrRKPkRKPyRKPgR | 286-289 (SU)286-289 (SU)498-501 (SU)498-501 (SU)185-188 (SU)729-732 (TM) |
| HIV-2 | 968 | 22 | 2.3 | KPrRKPkRKPgR | 177-180 (SU)177-180 (SU)374-377 (SU) |
| SIV | 3695 | 12 | 0.3 | KPkRKPdRKPiR | 420-423 (SU)751-754 (TM)15-18 (signal) |
| FIV | 455 | 61 | 13.4 | KPrR | 606-609 (SU) |
| Visna-Maedi virus | 163 | 20 | 12.3 | KPsR | 7-10 (signal) |
| EIAV | 795 | 2 | 0.3 | KPvR | 11-14 (signal) |
| γ or α retrovirus | |||||
| MLV | 134 | 0 | 0 | ||
| RSV | 18 | 1 | 5.6 | KPgR | 191-194 (SU) |
| Spumavirus | |||||
| EFV | 1 | 1 | 100 | KPiR | 834-837 (TM) |
| PFV/HFV | 1 | 0 | 0 | ||
| Retrovirus . | Sequences* . | Occurrence, percentage . | Motif type (no.) . | Motif position† . | |
|---|---|---|---|---|---|
| Total no. . | No. containing KPxR . | ||||
| δ retrovirus | |||||
| HTLV-1 | 255 | 254 | 99.6 | KPnR (246)KPyR (7)KPsR (1) | 91-94 (SU)91-94 (SU)91-94 (SU) |
| HTLV-2 | 15 | 14 | 93.3 | KPnR (14) | 87-90 (SU) |
| HTLV-3 | 2 | 2 | 100 | KPnR (1)KPdR (1) | 91-94 (SU)91-94 (SU) |
| STLV-1 | 33 | 32 | 97 | KPnR (32) | 91-94 (SU) |
| STLV-2 | 2 | 2 | 100 | KPnR (2) | 87-90 (SU) |
| STLV-3 | 4 | 4 | 100 | KPnR (4) | 89-92 (SU) |
| Baboon TLV | 1 | 1 | 100 | KPnR (1) | 91-94 (SU) |
| BLV | 113 | 0 | 0 | ||
| Lentivirus | |||||
| HIV-1 | 71364 | 345 | 0.5 | KPvRKPiRKPrRKPkRKPyRKPgR | 286-289 (SU)286-289 (SU)498-501 (SU)498-501 (SU)185-188 (SU)729-732 (TM) |
| HIV-2 | 968 | 22 | 2.3 | KPrRKPkRKPgR | 177-180 (SU)177-180 (SU)374-377 (SU) |
| SIV | 3695 | 12 | 0.3 | KPkRKPdRKPiR | 420-423 (SU)751-754 (TM)15-18 (signal) |
| FIV | 455 | 61 | 13.4 | KPrR | 606-609 (SU) |
| Visna-Maedi virus | 163 | 20 | 12.3 | KPsR | 7-10 (signal) |
| EIAV | 795 | 2 | 0.3 | KPvR | 11-14 (signal) |
| γ or α retrovirus | |||||
| MLV | 134 | 0 | 0 | ||
| RSV | 18 | 1 | 5.6 | KPgR | 191-194 (SU) |
| Spumavirus | |||||
| EFV | 1 | 1 | 100 | KPiR | 834-837 (TM) |
| PFV/HFV | 1 | 0 | 0 | ||
STLV indicates simian T-lymphotropic virus; HTLV, human T-lymphotropic virus; BLV, bovine leukemia virus; SIV, simian immunodeficiency virus; FIV, feline immunodeficiency virus; EIAV, equine infectious anemia virus; MLV, murine leukemia virus; RSV, Rous sarcoma virus; EFV, equine foamy virus; PFV, primate foamy virus; HFV, human foamy virus; SU, surface Env subunit; and TM, transmembrane Env subunit.
For T-lymphotropic viruses, only complete Env sequences and Env fragments encompassing the 90-94 region of the SU were considered. For other retroviruses, all complete and fragment Env sequences were considered.
Whether the consensus KPxR motif is found within the signal peptide, the SU or TM subunit of Env is indicated in parentheses.