Neutrophils effectively adhere to and phagocytose activated but not resting platelets after a 5-minute interaction at 37°C. Treatment with trypsin-EDTA, which acts in the extracellular environment, strips adherent but not internalized platelets (*P < .05 by paired t test). Hindrance with phosphatidylserine recognition by annexin A5 blocks platelet internalization but does not influence adhesion (*P < .05 by paired t test). Both platelet adhesion and internalization were nondetectable when (1) phagocytosis was blocked by annexin A5 and (2) extracellular platelets were removed after the assay by trypsin-EDTA (*P < .05 by paired t test). Platelet adherence and internalization were determined by flow cytometry, as described in “Adhesion and phagocytosis.” Results are expressed as mean ± SEM of 3 independent experiments performed in duplicate.