Table 1 Expression of α-spectrin/ A... | American Society of Hematology

Table 1

Expression of α-spectrin/^Aγ-globin mRNA in transgenic mice

Transgene construct	No. of expressing lines/total no. of lines	Copy number range	Copy number correlation	Mean human ^Aγ-globin/murine α-globin/copy
ASp/γ	0/7	1-5		Not detected
ASpEx1IVS1/γ	21/23	1-14	r² = 0.48	0.0042 + 0.004
			P = .001	P = .047*
ASpEx1IVS1 splice mutant/γ	9/9	1-10, 45	r² = 0.963	0.0047 + 0.003
			P = .001	P = .002*
ASpIVS1/γ	4/6	1-6		0.0055 + 0.0067
ASpEx1/γ	2/7	1-15		0.001 + 0.0006

Transgene construct	No. of expressing lines/total no. of lines	Copy number range	Copy number correlation	Mean human ^Aγ-globin/murine α-globin/copy
ASp/γ	0/7	1-5		Not detected
ASpEx1IVS1/γ	21/23	1-14	r² = 0.48	0.0042 + 0.004
			P = .001	P = .047*
ASpEx1IVS1 splice mutant/γ	9/9	1-10, 45	r² = 0.963	0.0047 + 0.003
			P = .001	P = .002*
ASpIVS1/γ	4/6	1-6		0.0055 + 0.0067
ASpEx1/γ	2/7	1-15		0.001 + 0.0006

P values from comparison versus mean human ^Aγ-globin/murine α-globin/copy of ASp/γ-transgenic mice.