Expression of α-spectrin/Aγ-globin mRNA in transgenic mice
| Transgene construct . | No. of expressing lines/total no. of lines . | Copy number range . | Copy number correlation . | Mean human Aγ-globin/murine α-globin/copy . |
|---|---|---|---|---|
| ASp/γ | 0/7 | 1-5 | Not detected | |
| ASpEx1IVS1/γ | 21/23 | 1-14 | r2 = 0.48 | 0.0042 + 0.004 |
| P = .001 | P = .047* | |||
| ASpEx1IVS1 splice mutant/γ | 9/9 | 1-10, 45 | r2 = 0.963 | 0.0047 + 0.003 |
| P = .001 | P = .002* | |||
| ASpIVS1/γ | 4/6 | 1-6 | 0.0055 + 0.0067 | |
| ASpEx1/γ | 2/7 | 1-15 | 0.001 + 0.0006 |
| Transgene construct . | No. of expressing lines/total no. of lines . | Copy number range . | Copy number correlation . | Mean human Aγ-globin/murine α-globin/copy . |
|---|---|---|---|---|
| ASp/γ | 0/7 | 1-5 | Not detected | |
| ASpEx1IVS1/γ | 21/23 | 1-14 | r2 = 0.48 | 0.0042 + 0.004 |
| P = .001 | P = .047* | |||
| ASpEx1IVS1 splice mutant/γ | 9/9 | 1-10, 45 | r2 = 0.963 | 0.0047 + 0.003 |
| P = .001 | P = .002* | |||
| ASpIVS1/γ | 4/6 | 1-6 | 0.0055 + 0.0067 | |
| ASpEx1/γ | 2/7 | 1-15 | 0.001 + 0.0006 |
P values from comparison versus mean human Aγ-globin/murine α-globin/copy of ASp/γ-transgenic mice.