Karyotypic findings in 33 cases of pediatric mixed-lineage leukemia
| Case type/number . | Karyotype . |
|---|---|
| Biphenotypic (B + T + My) | |
| 1 | 51,XY,+Y,+4,+6,+13,+22[18] |
| 2 | 46,XY,del(12)(p11.2p13)[16]/46,XY[4] |
| Biphenotypic (B + My) | |
| 3 | 46,XX,inv(3)(p25q21),del(6)(q13q21),t(4;12)(q12;p13),add(7)(q36),del(10)(q24)[4]/47,idem,+15[3]/46,XX[12] |
| 4 | 46,XY,t(10;11)(q22;q23)[20] |
| 5 | 46,X,-X,+8,der(16)t(1;16)(q21;q13)[18]/46,XX[4] |
| 6 | 46,XY,t(11;20)(q10;q10),del(12)(p12)[10]/46,XY[10] |
| 7 | 46,XY,del(5)(p14),del(11)(p13-15)[6]/46,XY[14] |
| 8 | 45,XY,dic(9;16)(p11;p11.2),i(17)(q10)[21] |
| 9 | 47,XX,+8,del(16)(q13)[1]/47,idem,del(9)(q22)[11]/46,XX[8] |
| 10 | 46,XY,dup(1)(q32q21)[10]/47,idem,add(5)(q31),del(6)(q13q23),+mar[7]/46,XY[3] |
| 11 | 47,XX,+mar[3]/46,XX[27] |
| 12 | 46,XY,t(2;11)(p11.2;p11.2),der(9)t(1;9)(q12;q34)[20] |
| Biphenotypic (T + My) | |
| 13 | 46,XX,t(2;14)(q24;q32),t(17;19)(p13;q13.1)[12]/46,idem,del(16)(q22)[3] |
| 14 | 46,XY,i(17)(q10)[1]/46,XX(Donor)[12]/46,XY[7] |
| 15 | 46,XX,der(2)?inv(2)(p11.2q13)t(2;14)(14qter->14q32.1::2p?->2qter),der(14)t(2;14)(14pter->14q32.1:: 2q13->2p12->2pter)[19]/46,XX[1] |
| 16 | 47,XX,t(7;12)(q36;p13),+19[19]/46,XX[1] |
| 17 | 46,XY[20] |
| 18 | 46,XX[29] |
| 19 | 46,XY[33] |
| 20 | 46,XX,t(4;11)(q21;p15)[20] |
| 21 | 46,XX,der(2)t(2;14)(q21;q32),add(5)(q31),der(14)ins(14;2)(q22;q21q37)[15]/46,XX[6] |
| 22 | 46,XY,inv(2)(p11.2q13)c,inv(2)(q13q35)[16]/4n,idem[2]/46,XY,inv(2)(p11.2q13)c[2] |
| 23 | NA |
| 24 | 46,XY[20] |
| 25 | 46,XY,inv(7)(p24q11.2)[20] |
| 31 | NA |
| 26 | 46,XY[25] |
| 27 | 46,XY,t(5;7)(q13.3;p13)[17]/46,XY[3] |
| 28 | 47,XY,der(1)add(1)(p36.3)add(1)(q32),t(4;7)(q21;p22),del(9)(p13),der(11)add(11)(p13)add(11)(q21), add(12)(p11.2),add(18)(q23),+mar[12]/46,idem,-der(11)add(11)[4]/47,idem,-der(1)add(1),-der(11)add(11), add(19)(p13.3)[3]/46,XY[6] |
| 29 | 46,XY,inv(7)(p15q34)[7]/46,XY,der(7)inv(7)t(1;7)(q31;p22)[5]/46,XY[8] |
| 30 | 46,XY[25] |
| 31 | 47,XY,+4[2]/46,XY[18] |
| 32 | 45,XX,t(8;12)(q13;p12-13),der(15)ins(15;17)(q15;q21q21),-17[7]/46,XX[14] |
| Bilineal (B + My) | |
| 33 | 46,XX,t(11;19)(q23;p13.1)[20] |
| 34 | 46,XY,t(9;11)(p13;q23)[18]/46,XY[2] |
| Undifferentiated acute leukemia | |
| 35 | 47,XX,der(7)inv(7)(p22q11.2)t(7;15)(p22;q15),t(9;11)(p22;q23),+10,der(15)t(7;15)[20] |
| Case type/number . | Karyotype . |
|---|---|
| Biphenotypic (B + T + My) | |
| 1 | 51,XY,+Y,+4,+6,+13,+22[18] |
| 2 | 46,XY,del(12)(p11.2p13)[16]/46,XY[4] |
| Biphenotypic (B + My) | |
| 3 | 46,XX,inv(3)(p25q21),del(6)(q13q21),t(4;12)(q12;p13),add(7)(q36),del(10)(q24)[4]/47,idem,+15[3]/46,XX[12] |
| 4 | 46,XY,t(10;11)(q22;q23)[20] |
| 5 | 46,X,-X,+8,der(16)t(1;16)(q21;q13)[18]/46,XX[4] |
| 6 | 46,XY,t(11;20)(q10;q10),del(12)(p12)[10]/46,XY[10] |
| 7 | 46,XY,del(5)(p14),del(11)(p13-15)[6]/46,XY[14] |
| 8 | 45,XY,dic(9;16)(p11;p11.2),i(17)(q10)[21] |
| 9 | 47,XX,+8,del(16)(q13)[1]/47,idem,del(9)(q22)[11]/46,XX[8] |
| 10 | 46,XY,dup(1)(q32q21)[10]/47,idem,add(5)(q31),del(6)(q13q23),+mar[7]/46,XY[3] |
| 11 | 47,XX,+mar[3]/46,XX[27] |
| 12 | 46,XY,t(2;11)(p11.2;p11.2),der(9)t(1;9)(q12;q34)[20] |
| Biphenotypic (T + My) | |
| 13 | 46,XX,t(2;14)(q24;q32),t(17;19)(p13;q13.1)[12]/46,idem,del(16)(q22)[3] |
| 14 | 46,XY,i(17)(q10)[1]/46,XX(Donor)[12]/46,XY[7] |
| 15 | 46,XX,der(2)?inv(2)(p11.2q13)t(2;14)(14qter->14q32.1::2p?->2qter),der(14)t(2;14)(14pter->14q32.1:: 2q13->2p12->2pter)[19]/46,XX[1] |
| 16 | 47,XX,t(7;12)(q36;p13),+19[19]/46,XX[1] |
| 17 | 46,XY[20] |
| 18 | 46,XX[29] |
| 19 | 46,XY[33] |
| 20 | 46,XX,t(4;11)(q21;p15)[20] |
| 21 | 46,XX,der(2)t(2;14)(q21;q32),add(5)(q31),der(14)ins(14;2)(q22;q21q37)[15]/46,XX[6] |
| 22 | 46,XY,inv(2)(p11.2q13)c,inv(2)(q13q35)[16]/4n,idem[2]/46,XY,inv(2)(p11.2q13)c[2] |
| 23 | NA |
| 24 | 46,XY[20] |
| 25 | 46,XY,inv(7)(p24q11.2)[20] |
| 31 | NA |
| 26 | 46,XY[25] |
| 27 | 46,XY,t(5;7)(q13.3;p13)[17]/46,XY[3] |
| 28 | 47,XY,der(1)add(1)(p36.3)add(1)(q32),t(4;7)(q21;p22),del(9)(p13),der(11)add(11)(p13)add(11)(q21), add(12)(p11.2),add(18)(q23),+mar[12]/46,idem,-der(11)add(11)[4]/47,idem,-der(1)add(1),-der(11)add(11), add(19)(p13.3)[3]/46,XY[6] |
| 29 | 46,XY,inv(7)(p15q34)[7]/46,XY,der(7)inv(7)t(1;7)(q31;p22)[5]/46,XY[8] |
| 30 | 46,XY[25] |
| 31 | 47,XY,+4[2]/46,XY[18] |
| 32 | 45,XX,t(8;12)(q13;p12-13),der(15)ins(15;17)(q15;q21q21),-17[7]/46,XX[14] |
| Bilineal (B + My) | |
| 33 | 46,XX,t(11;19)(q23;p13.1)[20] |
| 34 | 46,XY,t(9;11)(p13;q23)[18]/46,XY[2] |
| Undifferentiated acute leukemia | |
| 35 | 47,XX,der(7)inv(7)(p22q11.2)t(7;15)(p22;q15),t(9;11)(p22;q23),+10,der(15)t(7;15)[20] |
NA indicates not available.