Table 1

Immunophenotypic and cytochemical findings in 35 cases of pediatric mixed-lineage leukemia

Case type/numberB-lineage markersT-lineage markersLymphoid markers, NOSMyeloid markersMPO*Auer rods
Biphenotypic (B + T + My)       
    1 CD19, CD20 CD2, CD7  CD13, CD14, CD33 Positive† No 
    2 CD19, CD22, cyCD79a cyCD3, CD7 TdT CD11b, CD13, CD15, MPO 5 No 
Biphenotypic (B + My)       
    3 CD19, CD22, cyIgM  TdT, CD10 CD11, CD13, CD15, CD33, CD36, CD14 8 No 
    4 CD19, CD22, cyCD79a, cyIgM  TdT CD13, CD15, CD33, CD36, CD65, CD117 3 Yes 
    5 CD19, CD22  TdT, CD10 CD13, CD33 1 No 
    6 CD19, CD22, CD24 cyCD79a  TdT, CD10 CD11b, CD13, CD14, CD15, CD33, CD64, CD65 2 No 
    7 CD19, CD22  TdT CD15, CD33 3 No 
    8 CD19, CD20, CD22, CD24, cyIgMu, cyCD79a  TdT, CD10 MPO 2 No 
    9 CD19, CD22, CD24, cyCD79a  TdT CD11b, CD13, CD15, CD33, MPO 2 No 
    10 CD19, CD22, CD24, cyIgMu, cyCD79a  TdT CD13, CD15, CD33, MPO 5 No 
    11 CD19, CD20, CD22, CD24, cyCD79a  CD10 CD13, CD15, CD33, MPO 2 No 
    12 CD19, CD24, cyCD79a  TdT CD13, CD15, CD33, CD65 3 No 
Biphenotypic (T + My)       
    13  CD2,CD7 CD10 CD11, CD13, CD14, CD15, CD33 10 No 
    14  CD2, CD7, cyCD3 TdT CD13, CD15, CD36, CD117, MPO 6 Yes 
    15  cyCD3, CD2, CD5, CD7 TdT CD11b, CD13, CD15, CD33, CD65, CD117, MPO 46 Yes 
    16  cyCD3, CD4, CD5, CD7, CD56  CD11b, CD13, CD15, CD33, CD117, MPO 4 No 
    17 CD22, cyCD79a cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD117, MPO 4.5 Yes 
    18  CD2, CD7 TdT CD11, CD13, CD15, CD33 21 No 
    19  CD2, CD7 TdT CD13, CD15 3 No 
    20 CD19 cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD65 3.5 No 
    21  CD2, CD7, cyCD3  CD13, CD15, CD36, CD65, MPO 15 No 
    22 CD22 cyCD3, CD7, CD56  CD13, CD15, CD33, CD65, CD117, MPO 4 No 
    23 CD22, cyCD79a cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD65, MPO 2.3 Yes 
    24  cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD65, CD117 1 Yes 
    25 CD22 CD2, CD7, cyCD3 TdT CD11b, CD13, CD15, CD33, CD36, MPO 3 Yes 
    26  CD2, CD7 TdT CD13, CD33 5 No 
    27  cyCD3, CD2, CD4, CD5, CD7 TdT, CD10 CD13, CD33, MPO 36 No 
    28  cyCD3, CD5, CD7  CD13, CD33, CD117, MPO 90 No 
    29  CD2, CD5, CD7, cyCD3 TdT, CD10 CD11b, CD13, CD33, MPO 1 No 
    30 CD22 CD2, CD7, cyCD3 TdT CD11b, CD13, CD15, CD117, MPO 2.5 Yes 
    31  CD2, CD7 TdT CD11b, CD13, CD33 13 Yes 
    32  cyCD3, CD7, CD56  CD11b, CD13, CD15, CD33, MPO 0 No 
Bilineal (B + My)       
    33 CD19, CD22, cyCD79a  TdT CD11b, CD13, CD15, CD33, CD65, CD117, MPO 14 No 
    34 CD19, CD22, CD24, cyCD79a CD56 TdT CD11b, CD13, CD14, CD33, CD36, CD64, CD65 0 No 
Undifferentiated acute leukemia 
    35 CD22 CD7  CD11b, CD33 0 No 
Case type/numberB-lineage markersT-lineage markersLymphoid markers, NOSMyeloid markersMPO*Auer rods
Biphenotypic (B + T + My)       
    1 CD19, CD20 CD2, CD7  CD13, CD14, CD33 Positive† No 
    2 CD19, CD22, cyCD79a cyCD3, CD7 TdT CD11b, CD13, CD15, MPO 5 No 
Biphenotypic (B + My)       
    3 CD19, CD22, cyIgM  TdT, CD10 CD11, CD13, CD15, CD33, CD36, CD14 8 No 
    4 CD19, CD22, cyCD79a, cyIgM  TdT CD13, CD15, CD33, CD36, CD65, CD117 3 Yes 
    5 CD19, CD22  TdT, CD10 CD13, CD33 1 No 
    6 CD19, CD22, CD24 cyCD79a  TdT, CD10 CD11b, CD13, CD14, CD15, CD33, CD64, CD65 2 No 
    7 CD19, CD22  TdT CD15, CD33 3 No 
    8 CD19, CD20, CD22, CD24, cyIgMu, cyCD79a  TdT, CD10 MPO 2 No 
    9 CD19, CD22, CD24, cyCD79a  TdT CD11b, CD13, CD15, CD33, MPO 2 No 
    10 CD19, CD22, CD24, cyIgMu, cyCD79a  TdT CD13, CD15, CD33, MPO 5 No 
    11 CD19, CD20, CD22, CD24, cyCD79a  CD10 CD13, CD15, CD33, MPO 2 No 
    12 CD19, CD24, cyCD79a  TdT CD13, CD15, CD33, CD65 3 No 
Biphenotypic (T + My)       
    13  CD2,CD7 CD10 CD11, CD13, CD14, CD15, CD33 10 No 
    14  CD2, CD7, cyCD3 TdT CD13, CD15, CD36, CD117, MPO 6 Yes 
    15  cyCD3, CD2, CD5, CD7 TdT CD11b, CD13, CD15, CD33, CD65, CD117, MPO 46 Yes 
    16  cyCD3, CD4, CD5, CD7, CD56  CD11b, CD13, CD15, CD33, CD117, MPO 4 No 
    17 CD22, cyCD79a cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD117, MPO 4.5 Yes 
    18  CD2, CD7 TdT CD11, CD13, CD15, CD33 21 No 
    19  CD2, CD7 TdT CD13, CD15 3 No 
    20 CD19 cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD65 3.5 No 
    21  CD2, CD7, cyCD3  CD13, CD15, CD36, CD65, MPO 15 No 
    22 CD22 cyCD3, CD7, CD56  CD13, CD15, CD33, CD65, CD117, MPO 4 No 
    23 CD22, cyCD79a cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD65, MPO 2.3 Yes 
    24  cyCD3, CD2, CD7 TdT CD11b, CD13, CD15, CD33, CD65, CD117 1 Yes 
    25 CD22 CD2, CD7, cyCD3 TdT CD11b, CD13, CD15, CD33, CD36, MPO 3 Yes 
    26  CD2, CD7 TdT CD13, CD33 5 No 
    27  cyCD3, CD2, CD4, CD5, CD7 TdT, CD10 CD13, CD33, MPO 36 No 
    28  cyCD3, CD5, CD7  CD13, CD33, CD117, MPO 90 No 
    29  CD2, CD5, CD7, cyCD3 TdT, CD10 CD11b, CD13, CD33, MPO 1 No 
    30 CD22 CD2, CD7, cyCD3 TdT CD11b, CD13, CD15, CD117, MPO 2.5 Yes 
    31  CD2, CD7 TdT CD11b, CD13, CD33 13 Yes 
    32  cyCD3, CD7, CD56  CD11b, CD13, CD15, CD33, MPO 0 No 
Bilineal (B + My)       
    33 CD19, CD22, cyCD79a  TdT CD11b, CD13, CD15, CD33, CD65, CD117, MPO 14 No 
    34 CD19, CD22, CD24, cyCD79a CD56 TdT CD11b, CD13, CD14, CD33, CD36, CD64, CD65 0 No 
Undifferentiated acute leukemia 
    35 CD22 CD7  CD11b, CD33 0 No 
*

Percentage of cells that were positive for MPO by cytochemical staining.

†

Percentage of MPO-positive cells not available.

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