Table 2

G-CSF/dexamethasone mobilization of granulocytes modulates changes in expression profile of genes involved in different biological processes

Sequence IDPrimary sequence nameSequence codeSequence descriptionFold change
Transcription and regulation of transcription     
    1514893 CCNA1 NM_003914 Cyclin A1 21.01 
    1983249 SMARCA3 BF513730 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 10.43 
    1513827 MLXIP AB020674 MLX interacting protein 8.66 
    1519529 MSL3L1 NM_078629 Male-specific lethal 3-like 1 (Drosophila) 6.75 
    1521872 MEF2A NM_005587 MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) 6.47 
    1985292 ETS2 BX433326 V-ets erythroblastosis virus E26 oncogene homolog 2 5.59 
    1525013 BATF NM_006399 Basic leucine zipper transcription factor, ATF-like 5.58 
    1537803 ENO1 NM_001428 Enolase 1, (alpha) 5.50 
    1533218 HIPK2 BC041926 CDNA clone IMAGE:5300349 5.07 
    1522326 PHTF1 NM_006608 Putative homeodomain transcription factor 1 4.80 
    1533591 SIRT5 NM_012241 Sirtuin (silent mating type information regulation 2 homolog) 5 (Saccharomyces cerevisiae) 4.60 
    1512793 ZNF167 NM_018651 Zinc finger protein 167 4.30 
    1511846 PLAG1 NM_002655 Pleomorphic adenoma gene 1 4.26 
    1512354 ZNF438 AK095436 hypothetical protein LOC220929 4.20 
    1507417 DACH1 NM_080759 Dachshund homolog 1 (Drosophila) 4.04 
    1526663 ZNF438 NM_182755 Zinc finger protein 438 4.02 
    1537859 ZBTB20 NM_015642 Zinc finger and BTB domain containing 20 3.77 
    1522362 ZNF658 NM_033160 Zinc finger protein 658 3.75 
    1534837 ZNF254 NM_004876 Zinc finger protein 539 3.73 
    1507368 CCND3 NM_001760 Cyclin D3 3.69 
    1509049 VENTX NM_014468 VENT homeobox homolog (Xenopus laevis) 3.61 
    1985753 CRTC3 AK090443 CREB regulated transcription coactivator 3 3.58 
    1529278 XRN2 NM_012255 5′-3′ exoribonuclease 2 3.43 
    1522102 E2F2 NM_004091 E2F transcription factor 2 3.36 
    1517472 CCNC NM_005190 Cyclin C 3.07 
    1535521 KLF6 U51869 Kruppel-like factor 6 3.03 
    1537902 TSC22D1 NM_183422 TSC22 domain family, member 1 −3.01 
    1983175 MCM7 NM_182776 MCM7 minichromosome maintenance deficient −3.02 
    1529350 SSRP1 NM_003146 Structure specific recognition protein 1 −3.03 
    1505187 RELB NM_006509 V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (avian) −3.04 
    1537144 DEXI AK055529 dexamethasone-induced transcript −3.07 
    1516882 MEF2C NM_002397 MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) −3.09 
    1527019 CHAF1A NM_005483 Chromatin assembly factor 1, subunit A (p150) −3.25 
    1535620 NCOR2 NM_006312 Nuclear receptor co-repressor 2 −3.34 
    1523857 ZNF395 NM_018660 Zinc finger protein 395 −3.34 
    1512878 ZMYND11 NM_006624 Zinc finger, MYND domain containing 11 −3.35 
    1991240 HMGA1 NM_145904 High mobility group AT-hook 1 −3.37 
    1531990 HEY1 NM_012258 Hairy/enhancer-of-split related with YRPW motif 1 −3.39 
    1533586 ELK1 NM_005229 ELK1, member of ETS oncogene family −3.50 
    1515979 NR4A3 NM_173199 Nuclear receptor subfamily 4, group A, member 3 −3.58 
    1510333 THRA NM_003250 Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) −3.68 
    1537025 BTG2 NM_006763 BTG family, member 2 −3.73 
    1513189 TRERF1 NM_033502 Transcriptional regulating factor 1 −3.76 
    1511905 JARID2 NM_004973 Jumonji, AT-rich interactive domain 2 −3.81 
    1526826 ATF3 NM_004024 Activating transcription factor 3 −3.82 
    1523890 RASSF7 NM_003475 Ras association (RalGDS/AF−6) domain family 7 −3.84 
    1533807 MAFF NM_012323 V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) −3.89 
    1525862 JUN NM_002228 V-jun sarcoma virus 17 oncogene homolog (avian) −3.94 
    1507971 NRL NM_006177 Neural retina leucine zipper −4.09 
    1533916 LEF1 NM_016269 Lymphoid enhancer-binding factor 1 −4.22 
    1506607 ASF1B NM_018154 ASF1 antisilencing function 1 homolog B (S cerevisiae) −4.36 
    1509496 AES NM_198969 Amino-terminal enhancer of split −4.39 
    1533535 TAF4 NM_003185 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa −4.40 
    1508056 EGR3 NM_004430 Early growth response 3 −4.41 
    1533262 BRF1 BC016743 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S cerevisiae) −4.48 
    1533571 PHF6 NM_032458 PHD finger protein 6 −4.53 
    1517506 EGR2 NM_000399 Early growth response 2 (Krox−20 homolog, Drosophila) −4.66 
    1989375 SMAD3 NM_005902 SMAD, mothers against DPP homolog 3 (Drosophila) −4.97 
    1507856 MYB NM_005375 V-myb myeloblastosis viral oncogene homolog (avian) −5.06 
    1528623 OLIG2 NM_005806 Oligodendrocyte lineage transcription factor 2 −6.11 
    1524585 GATA1 NM_002049 GATA binding protein 1 (globin transcription factor 1) −6.64 
    1991493 PARP14 NM_017554 Poly (ADP-ribose) polymerase family, member 14 −7.03 
    1510055 PCGF5 BC007377 Polycomb group ring finger 5 −7.57 
    1510369 ASCL2 NM_005170 Achaete-scute complex-like 2 (Drosophila) −7.72 
    1522208 ZNF584 NM_173548 Zinc finger protein 584 −7.93 
    1523937 RPS6KA5 NM_004755 Ribosomal protein S6 kinase, 90 kDa, polypeptide 5 −8.07 
    1529851 ETV7 NM_016135 Ets variant gene 7 (TEL2 oncogene) −8.56 
    1506298 GATA6 NM_005257 GATA binding protein 6 −8.65 
    1989096 SSBP3 NM_001009955 Single stranded DNA binding protein 3 −8.76 
    1520503 NKX31 NM_006167 NK3 transcription factor related, locus 1 (Drosophila) −9.56 
    1522991 ZNF649 NM_023074 Zinc finger protein 649 −11.07 
    1514700 NR4A1 NM_002135 Nuclear receptor subfamily 4, group A, member 1 −92.91 
Signal transduction     
    1513543 GPR84 NM_020370 G protein-coupled receptor 84 25.51 
    1505483 EDG1 NM_001400 Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 18.05 
    1511321 PTGER2 NM_000956 Prostaglandin E receptor 2 (subtype EP2), 53 kDa 8.26 
    1511570 ARHGAP24 AK130576 Rho GTPase activating protein 24 7.28 
    1523886 PDE4D NM_006203 Phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) 6.64 
    1527053 MYO10 BC041694 Myosin X 6.48 
    1512860 MS4A4A NM_024021 Membrane-spanning 4-domains, subfamily A, member 4 6.12 
    1539087 DLC1 NM_182643 Deleted in liver cancer 1 5.96 
    1528643 MS4A6A NM_022349 Membrane-spanning 4-domains, subfamily A, member 6A 5.87 
    1524040 GPR141 NM_181791 G protein-coupled receptor 141 5.28 
    1989101 EDARADD NM_080738 EDAR-associated death domain 4.64 
    1508615 EXT1 NM_000127 Exostoses (multiple) 1 4.30 
    1521881 STK3 NM_006281 Serine/threonine kinase 3 (STE20 homolog, yeast) 3.79 
    1510158 ITPKC NM_025194 Inositol 1.4,5-trisphosphate 3-kinase C 3.63 
    1519571 CDC42EP3 NM_006449 CDC42 effector protein (Rho GTPase binding) 3 3.58 
    1534557 DPYSL3 NM_001387 Dihydropyrimidinase-like 3 3.54 
    1536781 RPS6KA3 NM_004586 Ribosomal protein S6 kinase, 90 kDa, polypeptide 3 3.53 
    1533999 HHIP NM_022475 Hedgehog interacting protein 3.50 
    1512578 GPR97 NM_170776 G protein-coupled receptor 97 3.42 
    1514738 SLC26A6 NM_022911 Inositol hexaphosphate kinase 2 3.28 
    1517434 IL4R NM_000418 Interleukin 4 receptor 3.21 
    1539209 GABBR1 NM_001470 Gamma-aminobutyric acid (GABA) B receptor, 1 3.19 
    1511435 STK16 NM_003691 Serine/threonine kinase 16 3.17 
    1520958 PRKAR2A BC002763 Inositol hexaphosphate kinase 2 3.12 
    1506387 MAPK6 NM_002748 Mitogen-activated protein kinase 6 3.03 
    1523162 ITPK1 NM_014216 Inositol 1.3,4-triphosphate 5/6 kinase −3.05 
    1507956 GNGT2 NM_031498 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 −3.09 
    1514326 TAGAP NM_138810 T-cell activation GTPase activating protein −3.09 
    1530414 GPR171 NM_013308 G protein-coupled receptor 171 −3.16 
    1527339 P2RY5 NM_005767 Purinergic receptor P2Y, G-protein coupled, 5 −3.17 
    1517355 ARHGAP25 BC039591 Rho GTPase activating protein 25 −3.23 
    1520830 KIT NM_000222 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog −3.28 
    1517660 KLRK1 NM_007360 Killer cell lectin-like receptor subfamily C, member 4 −3.37 
    1514077 KLRB1 NM_002258 Killer cell lectin-like receptor subfamily B, member 1 −3.43 
    1518328 GRP NM_002091 Gastrin-releasing peptide −3.64 
    1516849 EPHB1 NM_004441 EPH receptor B1 −3.80 
    1514753 PRKAG2 NM_016203 Protein kinase, AMP-activated, gamma 2 non-catalytic subunit −4.09 
    1512127 SOCS1 NM_003745 Suppressor of cytokine signaling 1 −4.13 
    1518864 FLT3LG NM_001459 Fms-related tyrosine kinase 3 ligand −4.26 
    1524915 OR51E1 NM_152430 Olfactory receptor, family 51, subfamily E, member 1 −4.27 
    1507227 P2RY14 NM_014879 Purinergic receptor P2Y, G-protein coupled, 14 −4.28 
    1523084 GUCA1A NM_000409 Guanylate cyclase activator 1A (retina) −4.37 
    1525046 PILRA NM_178273 Paired immunoglobulin-like type 2 receptor alpha −4.48 
    1534223 PPP1R12B NM_032105 Protein phosphatase 1, regulatory (inhibitor) subunit 12B −4.66 
    1518048 GPR34 NM_005300 G-protein–coupled receptor 34 −4.78 
    1534320 ARRB1 NM_004041 Arrestin, beta 1 −5.02 
    1534974 KLRD1 NM_002262 Killer cell lectin-like receptor subfamily D, member 1 −5.16 
    1525314 S100A10 NM_002966 S100 calcium binding protein A10 −5.94 
    1530940 PRKAR2B NM_002736 Protein kinase, cAMP-dependent, regulatory, type II, beta −5.97 
    1522410 IL2RB NM_000878 Interleukin 2 receptor, beta −6.06 
    1518652 CD74 NM_004355 CD74 molecule, major histocompatibility complex, class II invariant chain −6.23 
    1515002 CYSLTR1 NM_006639 Cysteinyl leukotriene receptor 1 −6.45 
    1530332 MX1 NM_002462 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) −6.76 
    1522509 OR2B2 NM_033057 Olfactory receptor, family 2, subfamily B, member 2 −6.88 
    1984459 PDE4B AB209081 Phosphodiesterase 4B, cAMP-specific −6.89 
    1527378 CSF1R NM_005211 Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog −7.08 
    1527858 NRGN NM_006176 Neurogranin (protein kinase C substrate, RC3) −7.49 
    1524392 ANGPT1 NM_001146 Angiopoietin 1 −8.84 
    1516837 MS4A3 NM_006138 Membrane-spanning 4-domains, subfamily A, member 3 −9.24 
    1989999 IL5RA NM_175725 Interleukin 5 receptor, alpha −9.66 
    1524637 GPR162 NM_019858 Triosephosphate isomerase 1 −10.10 
    1519217 P2RY2 NM_176072 Purinergic receptor P2Y, G-protein coupled, 2 −11.66 
    1516830 P2RY10 NM_014499 Purinergic receptor P2Y, G-protein coupled, 10 −11.67 
    1518123 CD83 NM_004233 CD83 molecule −11.67 
    1517216 KLRF1 NM_016523 Killer cell lectin-like receptor subfamily F, member 1 −12.68 
    1512228 EBI2 NM_004951 Epstein-Barr virus–induced gene 2 (lymphocyte-specific G protein-coupled receptor) −13.11 
    1513158 HRH4 NM_021624 Histamine receptor H4 −13.66 
    1537338 FGL2 NM_006682 Fibrinogen-like 2 −13.76 
    1515714 GNG11 NM_004126 Guanine nucleotide binding protein (G protein), gamma 11 −16.57 
    1527111 GPR44 NM_004778 G protein-coupled receptor 44 −23.51 
    1528909 RGS1 NM_002922 Regulator of G-protein signaling 1 −32.65 
Immune responses     
    1507161 CD163 NM_004244 CD163 molecule 54.27 
    1531927 CYP1B1 NM_000104 Cytochrome P450, family 1, subfamily B, polypeptide 1 46.19 
    1984958 CD177 CR592446 CD177 molecule 24.38 
    1521404 IL18R1 NM_003855 Interleukin 18 receptor 1 16.54 
    1983056 MERTK U08023 C-mer proto-oncogene tyrosine kinase 16.00 
    1532739 CLEC5A NM_013252 C-type lectin domain family 5, member A 13.44 
    1511835 CLEC4D NM_080387 C-type lectin domain family 4, member D 12.02 
    1535646 CST7 NM_003650 Cystatin F (leukocystatin) 11.43 
    1506996 ADORA3 NM_020683 Adenosine A3 receptor 10.89 
    1530098 IL18RAP NM_003853 Interleukin 18 receptor accessory protein 10.79 
    1532148 LAIR1 NM_021706 Leukocyte-associated immunoglobulin-like receptor 1 10.45 
    1506562 HP NM_005143 Haptoglobin 10.31 
    1505718 IL1R2 NM_004633 Interleukin 1 receptor, type II 9.95 
    1507483 LILRA5 NM_181879 Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 7.56 
    1524454 XBP1 NM_005080 X-box binding protein 1 7.48 
    1510813 IRAK3 NM_007199 Interleukin−1 receptor-associated kinase 3 7.28 
    1538778 TLR5 NM_003268 Toll-like receptor 5 5.97 
    1521047 CR1 NM_000651 Complement component (3b/4b) receptor 1 (Knops blood group) 5.87 
    1520792 MAPK14 NM_139013 Mitogen-activated protein kinase 14 5.75 
    1535716 CD59 NM_203330 CD59 molecule, complement regulatory protein 5.67 
    1513648 FCER1G CB529629 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 5.26 
    1521687 TLR4 BF670973 Toll-like receptor 4 5.15 
    1530114 MAP2K6 NM_002758 Mitogen-activated protein kinase kinase 6 4.87 
    1533789 SERPINB1 NM_030666 Serpin peptidase inhibitor, clade B (ovalbumin), member 1 4.84 
    1522193 FCAR NM_002000 Fc fragment of IgA, receptor for 4.52 
    1527121 PROK2 NM_021935 Prokineticin 2 4.33 
    1505831 CIAS1 NM_004895 Cold autoinflammatory syndrome 1 4.09 
    1524842 IL10 NM_000572 Interleukin 10 3.89 
    1538909 IL1RAP NM_002182 Interleukin 1 receptor accessory protein 3.80 
    1506853 CHIT1 NM_003465 Chitinase 1 (chitotriosidase) 3.48 
    1531091 CD55 NM_000574 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 3.39 
    1534101 IL1R1 NM_000877 Interleukin 1 receptor, type I 3.34 
    1515424 CYBB S67289 Cytochrome b-245, beta polypeptide (chronic granulomatous disease) 3.29 
    1985998 ALOX5 BQ548663 Arachidonate 5-lipoxygenase 3.16 
    1510372 IRAK4 NM_016123 Interleukin-1 receptor-associated kinase 4 3.10 
    1514172 CD48 NM_001778 CD48 molecule 3.09 
    1527340 TLR8 NM_016610 Toll-like receptor 8 3.07 
    1511452 SERPING1 NM_000062 Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) −3.00 
    1530131 IRF2BP2 BC020516 Interferon regulatory factor 2 binding protein 2 −3.03 
    1512742 CLEC7A NM_197954 C-type lectin domain family 7, member A −3.06 
    1528251 NCR3 NM_147130 Natural cytotoxicity triggering receptor 3 −3.13 
    1513772 HLA-DRB3 NM_022555 Major histocompatibility complex, class II, DR beta 1 −3.17 
    1518778 ALOX15 NM_001140 Arachidonate 15-lipoxygenase −3.24 
    1524640 OAS3 NM_006187 2'−5'-oligoadenylate synthetase 3, 100 kDa −3.31 
    1985491 HLA-DRB1 X12544 Major histocompatibility complex, class II, DR beta 1 −3.31 
    1519302 STAT1 NM_139266 Signal transducer and activator of transcription 1, 91 kDa −3.39 
    1509654 CTSW NM_001335 Cathepsin W (lymphopain) −3.45 
    1992017 PLAUR NM_001005377 Plasminogen activator, urokinase receptor −3.50 
    1526588 LY75 NM_002349 Lymphocyte antigen 75 −3.51 
    1536508 LST1 NM_007161 Leukocyte specific transcript 1 −3.64 
    1515890 FAIM3 NM_005449 Interleukin 24 −3.65 
    1511424 EMR3 NM_032571 Egf-like module containing, mucin-like, hormone receptor-like 3 −3.71 
    1534340 CD46 NM_002389 CD46 molecule, complement regulatory protein −3.83 
    1537056 GBP3 NM_018284 Guanylate binding protein 1, interferon-inducible, 67 kDa −3.86 
    1517555 CYP27A1 NM_000784 Cytochrome P450, family 27, subfamily A, polypeptide 1 −3.88 
    1516190 SAMHD1 NM_015474 SAM domain and HD domain 1 −3.89 
    1519488 HLA-DQB2 NM_182549 Major histocompatibility complex, class II, DQ beta 2 −3.94 
    1983904 IL32 NM_001012631 Interleukin 32 −3.99 
    1505541 GZMB NM_004131 Granzyme B −4.04 
    1536691 GZMK NM_002104 Granzyme K (granzyme 3; tryptase II) −4.67 
    1522713 GZMA NM_006144 Granzyme A −4.80 
    1510975 HLA-DRB5 NM_002125 Major histocompatibility complex, class II, DR beta 1 −5.13 
    1527466 HLA-DPA1 NM_033554 Major histocompatibility complex, class II, DP alpha 1 −5.16 
    1516918 B2M AK022379 Beta−2-microglobulin −5.43 
    1538818 HLA-DQB1 NM_002123 Major histocompatibility complex, class II, DQ beta 1 −5.87 
    1521122 SPON2 NM_012445 Spondin 2, extracellular matrix protein −5.95 
    1517271 PF4V1 NM_002620 Platelet factor 4 variant 1 −6.48 
    1508682 HLA-DPB1 NM_002121 Major histocompatibility complex, class II, DP beta 1 −6.67 
    1529151 OASL NM_003733 2′−5′-oligoadenylate synthetase-like −7.10 
    1987518 CYB561 NM_001017916 Cytochrome b-561 −7.39 
    1524314 IFI44 NM_006417 Interferon-induced protein 44 −7.91 
    1533656 DEFA4 NM_001925 Defensin, alpha 4, corticostatin −9.04 
    1526794 HLA-DRA NM_019111 Major histocompatibility complex, class II, DR alpha −10.12 
    1536919 HLA-DMB NM_002118 Major histocompatibility complex, class II, DM beta −10.73 
    1525510 PF4 NM_002619 Platelet factor 4 (chemokine (C-X-C motif) ligand 4) −11.03 
    1514544 DEFA3 NM_005217 Defensin, alpha 1 −11.85 
    1520461 CD69 NM_001781 CD69 molecule −28.65 
    1528045 IL8 NM_000584 Interleukin 8 −35.22 
    1533457 FCER1A NM_002001 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide −61.82 
Cell survival and apoptosis     
    1519170 GADD45A NM_001924 Growth arrest and DNA-damage-inducible, alpha 20.49 
    1531073 CARD12 NM_021209 Caspase recruitment domain family, member 12 11.37 
    1513896 BIRC1 NM_004536 Baculoviral IAP repeat-containing 1 10.55 
    1525148 ANXA1 NM_000700 Annexin A1 7.39 
    1533289 ANXA3 NM_005139 Annexin A3 7.33 
    1516682 CAST NM_001750 Calpastatin 6.97 
    1532823 PECR NM_018441 Peroxisomal trans−2-enoyl-CoA reductase 5.32 
    1539226 CARD6 NM_032587 Caspase recruitment domain family, member 6 5.15 
    1531614 ELMO2 NM_022086 Engulfment and cell motility 2 4.67 
    1512780 LGALS8 NM_006499 Lectin, galactoside-binding, soluble, 8 (galectin 8) 4.24 
    1505831 CIAS1 NM_004895 Cold autoinflammatory syndrome 1 4.09 
    1521881 STK3 NM_006281 Serine/threonine kinase 3 (STE20 homolog, yeast) 3.79 
    1526256 DDAH2 NM_013974 Dimethylarginine dimethylaminohydrolase 2 3.75 
    1522394 TNFRSF10A NM_003844 Tumor necrosis factor receptor superfamily, member 10a 3.69 
    1988846 AIM1 NM_001624 Absent in melanoma 1 3.52 
    1509305 LTB4R NM_181657 Leukotriene B4 receptor 3.20 
    1984749 HIP1 BC082970 Huntingtin interacting protein 1 3.19 
    1534293 LGALS3 NM_002306 Lectin, galactoside-binding, soluble, 3 (galectin 3) 3.03 
    1535837 SQSTM1 NM_003900 Sequestosome 1 −3.01 
    1537407 NFKBIE NM_004556 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon −3.12 
    1987065 TNFRSF25 NM_148968 Homo sapiens tumor necrosis factor receptor superfamily −3.36 
    1516125 PRDX2 NM_005809 Peroxiredoxin 2 −3.40 
    1531960 GSTP1 NM_000852 Glutathione S-transferase pi −3.42 
    1984701 CARD9 NM_052813 Caspase recruitment domain family, member 9 −3.61 
    1532501 PIM2 NM_006875 Pim−2 oncogene −3.76 
    1528041 IL31RA NM_139017 Interleukin 31 receptor A −3.91 
    1533374 PHLDA2 NM_003311 Pleckstrin homology-like domain, family A, member 2 −3.97 
    1526625 CARD4 NM_006092 Caspase recruitment domain family, member 4 −3.99 
    1520783 DYRK2 NM_006482 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 −4.29 
    1516378 TNFSF12 NM_153012 Tumor necrosis factor (ligand) superfamily, member 12 −4.29 
    1530737 LGALS2 NM_006498 Lectin, galactoside-binding, soluble, 2 (galectin 2) −4.47 
    1510435 LGALS12 NM_033101 Lectin, galactoside-binding, soluble, 12 (galectin 12) −4.47 
    1523074 HSPA9B NM_004134 Heat shock 70-kDa protein 9B (mortalin-2) −5.16 
    1532326 DDX58 NM_014314 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 −5.17 
    1508150 AOC3 NM_003734 Amine oxidase, copper containing 3 (vascular adhesion protein 1) −5.52 
    1538822 IFI6 NM_022873 Interferon, alpha-inducible protein (clone IFI-6–16) −5.56 
    1990540 CLU NM_203339 Clusterin −5.66 
    1517391 BIRC3 NM_001165 Baculoviral IAP repeat-containing 3 −6.55 
    1538745 SGK NM_005627 Serum/glucocorticoid regulated kinase −7.90 
    1523311 BIRC4BP NM_017523 XIAP associated factor-1 −9.09 
    1510278 NGFRAP1 NM_014380 Nerve growth factor receptor (TNFRSF16) associated protein 1 −9.35 
    1533140 NME5 NM_003551 Non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) −9.98 
    1533249 HIG2 NM_013332 hypoxia-inducible protein 2 −15.17 
Cell adhesion and motility     
    1536096 MMP8 NM_002424 Matrix metallopeptidase 8 (neutrophil collagenase) 97.77 
    1519153 OLFM4 NM_006418 Olfactomedin 4 23.81 
    1514453 CD44 NM_000610 CD44 molecule (Indian blood group) 10.05 
    1532879 EMILIN2 NM_032048 Elastin microfibril interfacer 2 9.85 
    1521082 CEACAM1 NM_001712 Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 5.97 
    1509526 MMP9 NM_004994 Matrix metallopeptidase 9 5.64 
    1522658 VNN1 NM_004666 Vanin 1 5.35 
    1984856 ADAM15 NM_207191 ADAM metallopeptidase domain 15 (metargidin) 3.79 
    1507356 F5 NM_000130 Coagulation factor V (proaccelerin, labile factor) 3.78 
    1516175 JAK2 NM_004972 Janus kinase 2 (a protein tyrosine kinase) 3.78 
    1508488 SPP1 NM_000582 Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) 3.72 
    1523771 ITGAM NM_000632 Integrin, alpha M (complement component 3 receptor 3 subunit) 3.52 
    1508621 PVRL2 NM_002856 Poliovirus receptor-related 2 (herpesvirus entry mediator B) 3.42 
    1531024 SIGLEC9 NM_014441 Sialic acid binding Ig-like lectin 9 3.34 
    1505504 VIM NM_003380 Vimentin 3.34 
    1986801 LAMB3 NM_001017402 Laminin, beta 3 3.11 
    1518582 CEACAM6 BC005008 Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) −3.07 
    1506966 SIGLEC8 NM_014442 Sialic acid binding immunoglobulin-like lectin 8 −3.16 
    1534776 CXCL1 NM_00–1511 Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) −3.20 
    1520341 AZU1 NM_001700 Azurocidin 1 (cationic antimicrobial protein 37) −3.23 
    1520433 ITGB7 NM_000889 Integrin, beta 7 −3.59 
    1505769 TUBB1 NM_030773 Tubulin, beta 1 −4.35 
    1528734 ICAM2 NM_000873 Intercellular adhesion molecule 2 −5.24 
    1991393 CXCR4 NM_001008540 Chemokine (C-X-C motif) receptor 4 −5.90 
    1989016 CCL3L3 NM_001001437 Chemokine (C-C motif) ligand 3-like 3 −5.98 
    1510688 CCL3 NM_002983 Chemokine (C-C motif) ligand 3 −6.35 
    1517696 CCL5 NM_002985 Chemokine (C-C motif) ligand 5 −7.71 
    1533135 CXCL10 NM_001565 Chemokine (C-X-C motif) ligand 11 −9.10 
    1505505 CCL23 NM_005064 Chemokine (C-C motif) ligand 23 −15.06 
    1526404 CCL4 NM_002984 Chemokine (C-C motif) ligand 4 −15.45 
    1533611 PPBP NM_002704 Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) −16.30 
    1515169 ITGA4 NM_000885 Integrin, alpha 4 (antigen CD49D), alpha 4 subunit of VLA-4 receptor −16.74 
    1537942 CCR3 NM_001837 Chemokine (C-C motif) receptor 3 −19.63 
Cell metabolism     
    1538977 HPGD NM_000860 Hydroxyprostaglandin dehydrogenase 15-(NAD) 36.27 
    1989284 PFKFB2 NM_001018053 6-phosphofructo-2-kinase/fructose-2.6-biphosphatase 2 31.40 
    1986330 ATP9A NM_006045 ATPase, Class II, type 9A 25.82 
    1511217 LDHA NM_005566 Lactate dehydrogenase A 10.11 
    1527335 PCSK9 NM_174936 Proprotein convertase subtilisin/kexin type 9 7.95 
    1991955 PLB1 CR600701 Phospholipase B1 7.59 
    1983476 ATP13A3 AJ306929 ATPase type 13A3 7.56 
    1513367 DPH5 NM_0–15958 DPH5 homolog (S cerevisiae) 6.38 
    1526202 NMNAT2 NM_0–15039 Nicotinamide nucleotide adenylyltransferase 2 6.31 
    1536086 DPYD NM_000110 Dihydropyrimidine dehydrogenase 6.11 
    1990338 ATP11B NM_014616 ATPase, Class VI, type 11B 6.09 
    1515968 ALPL NM_000478 Alkaline phosphatase, liver/bone/kidney 5.59 
    1506037 MGAM NM_004668 Maltase-glucoamylase (alpha-glucosidase) 5.41 
    1532823 PECR NM_018441 Peroxisomal trans-2-enoyl-CoA reductase 5.32 
    1986414 ATP2B4 NM_001001396 ATPase, Ca2+ transporting, plasma membrane 4 4.99 
    1506589 PFKFB3 NM_004566 6-phosphofructo-2-kinase/fructose-2.6-biphosphatase 3 4.75 
    1512399 AGPAT6 NM_178819 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) 4.74 
    1523383 PGD NM_002631 Phosphogluconate dehydrogenase 4.70 
    1519383 ATP6V1C1 NM_001695 ATPase, H+ transporting, lysosomal 42 kDa, V1 subunit C1 4.11 
    1520655 SMPDL3A NM_006714 Sphingomyelin phosphodiesterase, acid-like 3A 4.09 
    1989848 ACSL4 NM_004458 Acyl-CoA synthetase long-chain family member 4 4.02 
    1522656 LDLR NM_000527 Low-density lipoprotein receptor 3.63 
    1538541 DHRS9 NM_005771 Dehydrogenase/reductase (SDR family) member 9 3.55 
    1514810 ATP1A3 NM_152296 ATPase, Na+/K+ transporting, alpha 3 polypeptide 3.53 
    1524666 FABP5 NM_001444 Fatty acid binding protein 5 (psoriasis-associated) 3.38 
    1538372 ATP1A1 NM_000701 ATPase, Na+/K+ transporting, alpha 1 polypeptide 3.38 
    1524650 GNS NM_002076 Glucosamine (N-acetyl)-6- 3.37 
    1523432 ACSL1 NM_001995 Acyl-CoA synthetase long-chain family member 1 3.35 
    1529572 SGSH NM_000199 N-sulfoglucosamine sulfohydrolase (sulfamidase) 3.29 
    1538734 ACSL3 NM_004457 Acyl-CoA synthetase long-chain family member 3 3.27 
    1985998 ALOX5 BQ548663 Arachidonate 5-lipoxygenase 3.16 
    1527407 GAPDH NM_002046 Glyceraldehyde3-phosphate dehydrogenase 3.16 
    1534240 SULT1B1 D89479 Sulfotransferase family, cytosolic, 1B, member 1 3.10 
    1983183 NDUFB6 NM_182739 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 −3.10 
    1525237 ALDH6A1 NM_005589 Aldehyde dehydrogenase 6 family, member A1 −3.22 
    1518778 ALOX15 NM_001140 Arachidonate 15-lipoxygenase −3.24 
    1523761 CBR1 NM_001757 Carbonyl reductase 1 −3.61 
    1510672 MCCC1 NM_020166 Methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) −4.01 
    1990453 NDUFV2 BI520375 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa −4.31 
    1521732 ATP12A NM_001676 ATPase, H+/K+ transporting, nongastric, alpha polypeptide −4.74 
    1526184 LDHB NM_002300 Lactate dehydrogenase B −6.08 
    1512448 ISOC1 NM_016048 Isochorismatase domain containing 1 −6.51 
    1989369 METTL7A BC004492 Methyltransferase like 7A −6.99 
    1518627 FA2H NM_024306 Fatty acid 2-hydroxylase −7.75 
    1506804 PLD4 NM_138790 Phospholipase D family, member 4 −9.53 
    1521949 SORD NM_003104 Sorbitol dehydrogenase −10.20 
    1512822 SULF2 NM_018837 Sulfatase 2 −21.22 
Sequence IDPrimary sequence nameSequence codeSequence descriptionFold change
Transcription and regulation of transcription     
    1514893 CCNA1 NM_003914 Cyclin A1 21.01 
    1983249 SMARCA3 BF513730 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 10.43 
    1513827 MLXIP AB020674 MLX interacting protein 8.66 
    1519529 MSL3L1 NM_078629 Male-specific lethal 3-like 1 (Drosophila) 6.75 
    1521872 MEF2A NM_005587 MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) 6.47 
    1985292 ETS2 BX433326 V-ets erythroblastosis virus E26 oncogene homolog 2 5.59 
    1525013 BATF NM_006399 Basic leucine zipper transcription factor, ATF-like 5.58 
    1537803 ENO1 NM_001428 Enolase 1, (alpha) 5.50 
    1533218 HIPK2 BC041926 CDNA clone IMAGE:5300349 5.07 
    1522326 PHTF1 NM_006608 Putative homeodomain transcription factor 1 4.80 
    1533591 SIRT5 NM_012241 Sirtuin (silent mating type information regulation 2 homolog) 5 (Saccharomyces cerevisiae) 4.60 
    1512793 ZNF167 NM_018651 Zinc finger protein 167 4.30 
    1511846 PLAG1 NM_002655 Pleomorphic adenoma gene 1 4.26 
    1512354 ZNF438 AK095436 hypothetical protein LOC220929 4.20 
    1507417 DACH1 NM_080759 Dachshund homolog 1 (Drosophila) 4.04 
    1526663 ZNF438 NM_182755 Zinc finger protein 438 4.02 
    1537859 ZBTB20 NM_015642 Zinc finger and BTB domain containing 20 3.77 
    1522362 ZNF658 NM_033160 Zinc finger protein 658 3.75 
    1534837 ZNF254 NM_004876 Zinc finger protein 539 3.73 
    1507368 CCND3 NM_001760 Cyclin D3 3.69 
    1509049 VENTX NM_014468 VENT homeobox homolog (Xenopus laevis) 3.61 
    1985753 CRTC3 AK090443 CREB regulated transcription coactivator 3 3.58 
    1529278 XRN2 NM_012255 5′-3′ exoribonuclease 2 3.43 
    1522102 E2F2 NM_004091 E2F transcription factor 2 3.36 
    1517472 CCNC NM_005190 Cyclin C 3.07 
    1535521 KLF6 U51869 Kruppel-like factor 6 3.03 
    1537902 TSC22D1 NM_183422 TSC22 domain family, member 1 −3.01 
    1983175 MCM7 NM_182776 MCM7 minichromosome maintenance deficient −3.02 
    1529350 SSRP1 NM_003146 Structure specific recognition protein 1 −3.03 
    1505187 RELB NM_006509 V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (avian) −3.04 
    1537144 DEXI AK055529 dexamethasone-induced transcript −3.07 
    1516882 MEF2C NM_002397 MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) −3.09 
    1527019 CHAF1A NM_005483 Chromatin assembly factor 1, subunit A (p150) −3.25 
    1535620 NCOR2 NM_006312 Nuclear receptor co-repressor 2 −3.34 
    1523857 ZNF395 NM_018660 Zinc finger protein 395 −3.34 
    1512878 ZMYND11 NM_006624 Zinc finger, MYND domain containing 11 −3.35 
    1991240 HMGA1 NM_145904 High mobility group AT-hook 1 −3.37 
    1531990 HEY1 NM_012258 Hairy/enhancer-of-split related with YRPW motif 1 −3.39 
    1533586 ELK1 NM_005229 ELK1, member of ETS oncogene family −3.50 
    1515979 NR4A3 NM_173199 Nuclear receptor subfamily 4, group A, member 3 −3.58 
    1510333 THRA NM_003250 Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) −3.68 
    1537025 BTG2 NM_006763 BTG family, member 2 −3.73 
    1513189 TRERF1 NM_033502 Transcriptional regulating factor 1 −3.76 
    1511905 JARID2 NM_004973 Jumonji, AT-rich interactive domain 2 −3.81 
    1526826 ATF3 NM_004024 Activating transcription factor 3 −3.82 
    1523890 RASSF7 NM_003475 Ras association (RalGDS/AF−6) domain family 7 −3.84 
    1533807 MAFF NM_012323 V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) −3.89 
    1525862 JUN NM_002228 V-jun sarcoma virus 17 oncogene homolog (avian) −3.94 
    1507971 NRL NM_006177 Neural retina leucine zipper −4.09 
    1533916 LEF1 NM_016269 Lymphoid enhancer-binding factor 1 −4.22 
    1506607 ASF1B NM_018154 ASF1 antisilencing function 1 homolog B (S cerevisiae) −4.36 
    1509496 AES NM_198969 Amino-terminal enhancer of split −4.39 
    1533535 TAF4 NM_003185 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa −4.40 
    1508056 EGR3 NM_004430 Early growth response 3 −4.41 
    1533262 BRF1 BC016743 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S cerevisiae) −4.48 
    1533571 PHF6 NM_032458 PHD finger protein 6 −4.53 
    1517506 EGR2 NM_000399 Early growth response 2 (Krox−20 homolog, Drosophila) −4.66 
    1989375 SMAD3 NM_005902 SMAD, mothers against DPP homolog 3 (Drosophila) −4.97 
    1507856 MYB NM_005375 V-myb myeloblastosis viral oncogene homolog (avian) −5.06 
    1528623 OLIG2 NM_005806 Oligodendrocyte lineage transcription factor 2 −6.11 
    1524585 GATA1 NM_002049 GATA binding protein 1 (globin transcription factor 1) −6.64 
    1991493 PARP14 NM_017554 Poly (ADP-ribose) polymerase family, member 14 −7.03 
    1510055 PCGF5 BC007377 Polycomb group ring finger 5 −7.57 
    1510369 ASCL2 NM_005170 Achaete-scute complex-like 2 (Drosophila) −7.72 
    1522208 ZNF584 NM_173548 Zinc finger protein 584 −7.93 
    1523937 RPS6KA5 NM_004755 Ribosomal protein S6 kinase, 90 kDa, polypeptide 5 −8.07 
    1529851 ETV7 NM_016135 Ets variant gene 7 (TEL2 oncogene) −8.56 
    1506298 GATA6 NM_005257 GATA binding protein 6 −8.65 
    1989096 SSBP3 NM_001009955 Single stranded DNA binding protein 3 −8.76 
    1520503 NKX31 NM_006167 NK3 transcription factor related, locus 1 (Drosophila) −9.56 
    1522991 ZNF649 NM_023074 Zinc finger protein 649 −11.07 
    1514700 NR4A1 NM_002135 Nuclear receptor subfamily 4, group A, member 1 −92.91 
Signal transduction     
    1513543 GPR84 NM_020370 G protein-coupled receptor 84 25.51 
    1505483 EDG1 NM_001400 Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 18.05 
    1511321 PTGER2 NM_000956 Prostaglandin E receptor 2 (subtype EP2), 53 kDa 8.26 
    1511570 ARHGAP24 AK130576 Rho GTPase activating protein 24 7.28 
    1523886 PDE4D NM_006203 Phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) 6.64 
    1527053 MYO10 BC041694 Myosin X 6.48 
    1512860 MS4A4A NM_024021 Membrane-spanning 4-domains, subfamily A, member 4 6.12 
    1539087 DLC1 NM_182643 Deleted in liver cancer 1 5.96 
    1528643 MS4A6A NM_022349 Membrane-spanning 4-domains, subfamily A, member 6A 5.87 
    1524040 GPR141 NM_181791 G protein-coupled receptor 141 5.28 
    1989101 EDARADD NM_080738 EDAR-associated death domain 4.64 
    1508615 EXT1 NM_000127 Exostoses (multiple) 1 4.30 
    1521881 STK3 NM_006281 Serine/threonine kinase 3 (STE20 homolog, yeast) 3.79 
    1510158 ITPKC NM_025194 Inositol 1.4,5-trisphosphate 3-kinase C 3.63 
    1519571 CDC42EP3 NM_006449 CDC42 effector protein (Rho GTPase binding) 3 3.58 
    1534557 DPYSL3 NM_001387 Dihydropyrimidinase-like 3 3.54 
    1536781 RPS6KA3 NM_004586 Ribosomal protein S6 kinase, 90 kDa, polypeptide 3 3.53 
    1533999 HHIP NM_022475 Hedgehog interacting protein 3.50 
    1512578 GPR97 NM_170776 G protein-coupled receptor 97 3.42 
    1514738 SLC26A6 NM_022911 Inositol hexaphosphate kinase 2 3.28 
    1517434 IL4R NM_000418 Interleukin 4 receptor 3.21 
    1539209 GABBR1 NM_001470 Gamma-aminobutyric acid (GABA) B receptor, 1 3.19 
    1511435 STK16 NM_003691 Serine/threonine kinase 16 3.17 
    1520958 PRKAR2A BC002763 Inositol hexaphosphate kinase 2 3.12 
    1506387 MAPK6 NM_002748 Mitogen-activated protein kinase 6 3.03 
    1523162 ITPK1 NM_014216 Inositol 1.3,4-triphosphate 5/6 kinase −3.05 
    1507956 GNGT2 NM_031498 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 −3.09 
    1514326 TAGAP NM_138810 T-cell activation GTPase activating protein −3.09 
    1530414 GPR171 NM_013308 G protein-coupled receptor 171 −3.16 
    1527339 P2RY5 NM_005767 Purinergic receptor P2Y, G-protein coupled, 5 −3.17 
    1517355 ARHGAP25 BC039591 Rho GTPase activating protein 25 −3.23 
    1520830 KIT NM_000222 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog −3.28 
    1517660 KLRK1 NM_007360 Killer cell lectin-like receptor subfamily C, member 4 −3.37 
    1514077 KLRB1 NM_002258 Killer cell lectin-like receptor subfamily B, member 1 −3.43 
    1518328 GRP NM_002091 Gastrin-releasing peptide −3.64 
    1516849 EPHB1 NM_004441 EPH receptor B1 −3.80 
    1514753 PRKAG2 NM_016203 Protein kinase, AMP-activated, gamma 2 non-catalytic subunit −4.09 
    1512127 SOCS1 NM_003745 Suppressor of cytokine signaling 1 −4.13 
    1518864 FLT3LG NM_001459 Fms-related tyrosine kinase 3 ligand −4.26 
    1524915 OR51E1 NM_152430 Olfactory receptor, family 51, subfamily E, member 1 −4.27 
    1507227 P2RY14 NM_014879 Purinergic receptor P2Y, G-protein coupled, 14 −4.28 
    1523084 GUCA1A NM_000409 Guanylate cyclase activator 1A (retina) −4.37 
    1525046 PILRA NM_178273 Paired immunoglobulin-like type 2 receptor alpha −4.48 
    1534223 PPP1R12B NM_032105 Protein phosphatase 1, regulatory (inhibitor) subunit 12B −4.66 
    1518048 GPR34 NM_005300 G-protein–coupled receptor 34 −4.78 
    1534320 ARRB1 NM_004041 Arrestin, beta 1 −5.02 
    1534974 KLRD1 NM_002262 Killer cell lectin-like receptor subfamily D, member 1 −5.16 
    1525314 S100A10 NM_002966 S100 calcium binding protein A10 −5.94 
    1530940 PRKAR2B NM_002736 Protein kinase, cAMP-dependent, regulatory, type II, beta −5.97 
    1522410 IL2RB NM_000878 Interleukin 2 receptor, beta −6.06 
    1518652 CD74 NM_004355 CD74 molecule, major histocompatibility complex, class II invariant chain −6.23 
    1515002 CYSLTR1 NM_006639 Cysteinyl leukotriene receptor 1 −6.45 
    1530332 MX1 NM_002462 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) −6.76 
    1522509 OR2B2 NM_033057 Olfactory receptor, family 2, subfamily B, member 2 −6.88 
    1984459 PDE4B AB209081 Phosphodiesterase 4B, cAMP-specific −6.89 
    1527378 CSF1R NM_005211 Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog −7.08 
    1527858 NRGN NM_006176 Neurogranin (protein kinase C substrate, RC3) −7.49 
    1524392 ANGPT1 NM_001146 Angiopoietin 1 −8.84 
    1516837 MS4A3 NM_006138 Membrane-spanning 4-domains, subfamily A, member 3 −9.24 
    1989999 IL5RA NM_175725 Interleukin 5 receptor, alpha −9.66 
    1524637 GPR162 NM_019858 Triosephosphate isomerase 1 −10.10 
    1519217 P2RY2 NM_176072 Purinergic receptor P2Y, G-protein coupled, 2 −11.66 
    1516830 P2RY10 NM_014499 Purinergic receptor P2Y, G-protein coupled, 10 −11.67 
    1518123 CD83 NM_004233 CD83 molecule −11.67 
    1517216 KLRF1 NM_016523 Killer cell lectin-like receptor subfamily F, member 1 −12.68 
    1512228 EBI2 NM_004951 Epstein-Barr virus–induced gene 2 (lymphocyte-specific G protein-coupled receptor) −13.11 
    1513158 HRH4 NM_021624 Histamine receptor H4 −13.66 
    1537338 FGL2 NM_006682 Fibrinogen-like 2 −13.76 
    1515714 GNG11 NM_004126 Guanine nucleotide binding protein (G protein), gamma 11 −16.57 
    1527111 GPR44 NM_004778 G protein-coupled receptor 44 −23.51 
    1528909 RGS1 NM_002922 Regulator of G-protein signaling 1 −32.65 
Immune responses     
    1507161 CD163 NM_004244 CD163 molecule 54.27 
    1531927 CYP1B1 NM_000104 Cytochrome P450, family 1, subfamily B, polypeptide 1 46.19 
    1984958 CD177 CR592446 CD177 molecule 24.38 
    1521404 IL18R1 NM_003855 Interleukin 18 receptor 1 16.54 
    1983056 MERTK U08023 C-mer proto-oncogene tyrosine kinase 16.00 
    1532739 CLEC5A NM_013252 C-type lectin domain family 5, member A 13.44 
    1511835 CLEC4D NM_080387 C-type lectin domain family 4, member D 12.02 
    1535646 CST7 NM_003650 Cystatin F (leukocystatin) 11.43 
    1506996 ADORA3 NM_020683 Adenosine A3 receptor 10.89 
    1530098 IL18RAP NM_003853 Interleukin 18 receptor accessory protein 10.79 
    1532148 LAIR1 NM_021706 Leukocyte-associated immunoglobulin-like receptor 1 10.45 
    1506562 HP NM_005143 Haptoglobin 10.31 
    1505718 IL1R2 NM_004633 Interleukin 1 receptor, type II 9.95 
    1507483 LILRA5 NM_181879 Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 7.56 
    1524454 XBP1 NM_005080 X-box binding protein 1 7.48 
    1510813 IRAK3 NM_007199 Interleukin−1 receptor-associated kinase 3 7.28 
    1538778 TLR5 NM_003268 Toll-like receptor 5 5.97 
    1521047 CR1 NM_000651 Complement component (3b/4b) receptor 1 (Knops blood group) 5.87 
    1520792 MAPK14 NM_139013 Mitogen-activated protein kinase 14 5.75 
    1535716 CD59 NM_203330 CD59 molecule, complement regulatory protein 5.67 
    1513648 FCER1G CB529629 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 5.26 
    1521687 TLR4 BF670973 Toll-like receptor 4 5.15 
    1530114 MAP2K6 NM_002758 Mitogen-activated protein kinase kinase 6 4.87 
    1533789 SERPINB1 NM_030666 Serpin peptidase inhibitor, clade B (ovalbumin), member 1 4.84 
    1522193 FCAR NM_002000 Fc fragment of IgA, receptor for 4.52 
    1527121 PROK2 NM_021935 Prokineticin 2 4.33 
    1505831 CIAS1 NM_004895 Cold autoinflammatory syndrome 1 4.09 
    1524842 IL10 NM_000572 Interleukin 10 3.89 
    1538909 IL1RAP NM_002182 Interleukin 1 receptor accessory protein 3.80 
    1506853 CHIT1 NM_003465 Chitinase 1 (chitotriosidase) 3.48 
    1531091 CD55 NM_000574 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 3.39 
    1534101 IL1R1 NM_000877 Interleukin 1 receptor, type I 3.34 
    1515424 CYBB S67289 Cytochrome b-245, beta polypeptide (chronic granulomatous disease) 3.29 
    1985998 ALOX5 BQ548663 Arachidonate 5-lipoxygenase 3.16 
    1510372 IRAK4 NM_016123 Interleukin-1 receptor-associated kinase 4 3.10 
    1514172 CD48 NM_001778 CD48 molecule 3.09 
    1527340 TLR8 NM_016610 Toll-like receptor 8 3.07 
    1511452 SERPING1 NM_000062 Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) −3.00 
    1530131 IRF2BP2 BC020516 Interferon regulatory factor 2 binding protein 2 −3.03 
    1512742 CLEC7A NM_197954 C-type lectin domain family 7, member A −3.06 
    1528251 NCR3 NM_147130 Natural cytotoxicity triggering receptor 3 −3.13 
    1513772 HLA-DRB3 NM_022555 Major histocompatibility complex, class II, DR beta 1 −3.17 
    1518778 ALOX15 NM_001140 Arachidonate 15-lipoxygenase −3.24 
    1524640 OAS3 NM_006187 2'−5'-oligoadenylate synthetase 3, 100 kDa −3.31 
    1985491 HLA-DRB1 X12544 Major histocompatibility complex, class II, DR beta 1 −3.31 
    1519302 STAT1 NM_139266 Signal transducer and activator of transcription 1, 91 kDa −3.39 
    1509654 CTSW NM_001335 Cathepsin W (lymphopain) −3.45 
    1992017 PLAUR NM_001005377 Plasminogen activator, urokinase receptor −3.50 
    1526588 LY75 NM_002349 Lymphocyte antigen 75 −3.51 
    1536508 LST1 NM_007161 Leukocyte specific transcript 1 −3.64 
    1515890 FAIM3 NM_005449 Interleukin 24 −3.65 
    1511424 EMR3 NM_032571 Egf-like module containing, mucin-like, hormone receptor-like 3 −3.71 
    1534340 CD46 NM_002389 CD46 molecule, complement regulatory protein −3.83 
    1537056 GBP3 NM_018284 Guanylate binding protein 1, interferon-inducible, 67 kDa −3.86 
    1517555 CYP27A1 NM_000784 Cytochrome P450, family 27, subfamily A, polypeptide 1 −3.88 
    1516190 SAMHD1 NM_015474 SAM domain and HD domain 1 −3.89 
    1519488 HLA-DQB2 NM_182549 Major histocompatibility complex, class II, DQ beta 2 −3.94 
    1983904 IL32 NM_001012631 Interleukin 32 −3.99 
    1505541 GZMB NM_004131 Granzyme B −4.04 
    1536691 GZMK NM_002104 Granzyme K (granzyme 3; tryptase II) −4.67 
    1522713 GZMA NM_006144 Granzyme A −4.80 
    1510975 HLA-DRB5 NM_002125 Major histocompatibility complex, class II, DR beta 1 −5.13 
    1527466 HLA-DPA1 NM_033554 Major histocompatibility complex, class II, DP alpha 1 −5.16 
    1516918 B2M AK022379 Beta−2-microglobulin −5.43 
    1538818 HLA-DQB1 NM_002123 Major histocompatibility complex, class II, DQ beta 1 −5.87 
    1521122 SPON2 NM_012445 Spondin 2, extracellular matrix protein −5.95 
    1517271 PF4V1 NM_002620 Platelet factor 4 variant 1 −6.48 
    1508682 HLA-DPB1 NM_002121 Major histocompatibility complex, class II, DP beta 1 −6.67 
    1529151 OASL NM_003733 2′−5′-oligoadenylate synthetase-like −7.10 
    1987518 CYB561 NM_001017916 Cytochrome b-561 −7.39 
    1524314 IFI44 NM_006417 Interferon-induced protein 44 −7.91 
    1533656 DEFA4 NM_001925 Defensin, alpha 4, corticostatin −9.04 
    1526794 HLA-DRA NM_019111 Major histocompatibility complex, class II, DR alpha −10.12 
    1536919 HLA-DMB NM_002118 Major histocompatibility complex, class II, DM beta −10.73 
    1525510 PF4 NM_002619 Platelet factor 4 (chemokine (C-X-C motif) ligand 4) −11.03 
    1514544 DEFA3 NM_005217 Defensin, alpha 1 −11.85 
    1520461 CD69 NM_001781 CD69 molecule −28.65 
    1528045 IL8 NM_000584 Interleukin 8 −35.22 
    1533457 FCER1A NM_002001 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide −61.82 
Cell survival and apoptosis     
    1519170 GADD45A NM_001924 Growth arrest and DNA-damage-inducible, alpha 20.49 
    1531073 CARD12 NM_021209 Caspase recruitment domain family, member 12 11.37 
    1513896 BIRC1 NM_004536 Baculoviral IAP repeat-containing 1 10.55 
    1525148 ANXA1 NM_000700 Annexin A1 7.39 
    1533289 ANXA3 NM_005139 Annexin A3 7.33 
    1516682 CAST NM_001750 Calpastatin 6.97 
    1532823 PECR NM_018441 Peroxisomal trans−2-enoyl-CoA reductase 5.32 
    1539226 CARD6 NM_032587 Caspase recruitment domain family, member 6 5.15 
    1531614 ELMO2 NM_022086 Engulfment and cell motility 2 4.67 
    1512780 LGALS8 NM_006499 Lectin, galactoside-binding, soluble, 8 (galectin 8) 4.24 
    1505831 CIAS1 NM_004895 Cold autoinflammatory syndrome 1 4.09 
    1521881 STK3 NM_006281 Serine/threonine kinase 3 (STE20 homolog, yeast) 3.79 
    1526256 DDAH2 NM_013974 Dimethylarginine dimethylaminohydrolase 2 3.75 
    1522394 TNFRSF10A NM_003844 Tumor necrosis factor receptor superfamily, member 10a 3.69 
    1988846 AIM1 NM_001624 Absent in melanoma 1 3.52 
    1509305 LTB4R NM_181657 Leukotriene B4 receptor 3.20 
    1984749 HIP1 BC082970 Huntingtin interacting protein 1 3.19 
    1534293 LGALS3 NM_002306 Lectin, galactoside-binding, soluble, 3 (galectin 3) 3.03 
    1535837 SQSTM1 NM_003900 Sequestosome 1 −3.01 
    1537407 NFKBIE NM_004556 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon −3.12 
    1987065 TNFRSF25 NM_148968 Homo sapiens tumor necrosis factor receptor superfamily −3.36 
    1516125 PRDX2 NM_005809 Peroxiredoxin 2 −3.40 
    1531960 GSTP1 NM_000852 Glutathione S-transferase pi −3.42 
    1984701 CARD9 NM_052813 Caspase recruitment domain family, member 9 −3.61 
    1532501 PIM2 NM_006875 Pim−2 oncogene −3.76 
    1528041 IL31RA NM_139017 Interleukin 31 receptor A −3.91 
    1533374 PHLDA2 NM_003311 Pleckstrin homology-like domain, family A, member 2 −3.97 
    1526625 CARD4 NM_006092 Caspase recruitment domain family, member 4 −3.99 
    1520783 DYRK2 NM_006482 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 −4.29 
    1516378 TNFSF12 NM_153012 Tumor necrosis factor (ligand) superfamily, member 12 −4.29 
    1530737 LGALS2 NM_006498 Lectin, galactoside-binding, soluble, 2 (galectin 2) −4.47 
    1510435 LGALS12 NM_033101 Lectin, galactoside-binding, soluble, 12 (galectin 12) −4.47 
    1523074 HSPA9B NM_004134 Heat shock 70-kDa protein 9B (mortalin-2) −5.16 
    1532326 DDX58 NM_014314 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 −5.17 
    1508150 AOC3 NM_003734 Amine oxidase, copper containing 3 (vascular adhesion protein 1) −5.52 
    1538822 IFI6 NM_022873 Interferon, alpha-inducible protein (clone IFI-6–16) −5.56 
    1990540 CLU NM_203339 Clusterin −5.66 
    1517391 BIRC3 NM_001165 Baculoviral IAP repeat-containing 3 −6.55 
    1538745 SGK NM_005627 Serum/glucocorticoid regulated kinase −7.90 
    1523311 BIRC4BP NM_017523 XIAP associated factor-1 −9.09 
    1510278 NGFRAP1 NM_014380 Nerve growth factor receptor (TNFRSF16) associated protein 1 −9.35 
    1533140 NME5 NM_003551 Non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) −9.98 
    1533249 HIG2 NM_013332 hypoxia-inducible protein 2 −15.17 
Cell adhesion and motility     
    1536096 MMP8 NM_002424 Matrix metallopeptidase 8 (neutrophil collagenase) 97.77 
    1519153 OLFM4 NM_006418 Olfactomedin 4 23.81 
    1514453 CD44 NM_000610 CD44 molecule (Indian blood group) 10.05 
    1532879 EMILIN2 NM_032048 Elastin microfibril interfacer 2 9.85 
    1521082 CEACAM1 NM_001712 Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 5.97 
    1509526 MMP9 NM_004994 Matrix metallopeptidase 9 5.64 
    1522658 VNN1 NM_004666 Vanin 1 5.35 
    1984856 ADAM15 NM_207191 ADAM metallopeptidase domain 15 (metargidin) 3.79 
    1507356 F5 NM_000130 Coagulation factor V (proaccelerin, labile factor) 3.78 
    1516175 JAK2 NM_004972 Janus kinase 2 (a protein tyrosine kinase) 3.78 
    1508488 SPP1 NM_000582 Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) 3.72 
    1523771 ITGAM NM_000632 Integrin, alpha M (complement component 3 receptor 3 subunit) 3.52 
    1508621 PVRL2 NM_002856 Poliovirus receptor-related 2 (herpesvirus entry mediator B) 3.42 
    1531024 SIGLEC9 NM_014441 Sialic acid binding Ig-like lectin 9 3.34 
    1505504 VIM NM_003380 Vimentin 3.34 
    1986801 LAMB3 NM_001017402 Laminin, beta 3 3.11 
    1518582 CEACAM6 BC005008 Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) −3.07 
    1506966 SIGLEC8 NM_014442 Sialic acid binding immunoglobulin-like lectin 8 −3.16 
    1534776 CXCL1 NM_00–1511 Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) −3.20 
    1520341 AZU1 NM_001700 Azurocidin 1 (cationic antimicrobial protein 37) −3.23 
    1520433 ITGB7 NM_000889 Integrin, beta 7 −3.59 
    1505769 TUBB1 NM_030773 Tubulin, beta 1 −4.35 
    1528734 ICAM2 NM_000873 Intercellular adhesion molecule 2 −5.24 
    1991393 CXCR4 NM_001008540 Chemokine (C-X-C motif) receptor 4 −5.90 
    1989016 CCL3L3 NM_001001437 Chemokine (C-C motif) ligand 3-like 3 −5.98 
    1510688 CCL3 NM_002983 Chemokine (C-C motif) ligand 3 −6.35 
    1517696 CCL5 NM_002985 Chemokine (C-C motif) ligand 5 −7.71 
    1533135 CXCL10 NM_001565 Chemokine (C-X-C motif) ligand 11 −9.10 
    1505505 CCL23 NM_005064 Chemokine (C-C motif) ligand 23 −15.06 
    1526404 CCL4 NM_002984 Chemokine (C-C motif) ligand 4 −15.45 
    1533611 PPBP NM_002704 Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) −16.30 
    1515169 ITGA4 NM_000885 Integrin, alpha 4 (antigen CD49D), alpha 4 subunit of VLA-4 receptor −16.74 
    1537942 CCR3 NM_001837 Chemokine (C-C motif) receptor 3 −19.63 
Cell metabolism     
    1538977 HPGD NM_000860 Hydroxyprostaglandin dehydrogenase 15-(NAD) 36.27 
    1989284 PFKFB2 NM_001018053 6-phosphofructo-2-kinase/fructose-2.6-biphosphatase 2 31.40 
    1986330 ATP9A NM_006045 ATPase, Class II, type 9A 25.82 
    1511217 LDHA NM_005566 Lactate dehydrogenase A 10.11 
    1527335 PCSK9 NM_174936 Proprotein convertase subtilisin/kexin type 9 7.95 
    1991955 PLB1 CR600701 Phospholipase B1 7.59 
    1983476 ATP13A3 AJ306929 ATPase type 13A3 7.56 
    1513367 DPH5 NM_0–15958 DPH5 homolog (S cerevisiae) 6.38 
    1526202 NMNAT2 NM_0–15039 Nicotinamide nucleotide adenylyltransferase 2 6.31 
    1536086 DPYD NM_000110 Dihydropyrimidine dehydrogenase 6.11 
    1990338 ATP11B NM_014616 ATPase, Class VI, type 11B 6.09 
    1515968 ALPL NM_000478 Alkaline phosphatase, liver/bone/kidney 5.59 
    1506037 MGAM NM_004668 Maltase-glucoamylase (alpha-glucosidase) 5.41 
    1532823 PECR NM_018441 Peroxisomal trans-2-enoyl-CoA reductase 5.32 
    1986414 ATP2B4 NM_001001396 ATPase, Ca2+ transporting, plasma membrane 4 4.99 
    1506589 PFKFB3 NM_004566 6-phosphofructo-2-kinase/fructose-2.6-biphosphatase 3 4.75 
    1512399 AGPAT6 NM_178819 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) 4.74 
    1523383 PGD NM_002631 Phosphogluconate dehydrogenase 4.70 
    1519383 ATP6V1C1 NM_001695 ATPase, H+ transporting, lysosomal 42 kDa, V1 subunit C1 4.11 
    1520655 SMPDL3A NM_006714 Sphingomyelin phosphodiesterase, acid-like 3A 4.09 
    1989848 ACSL4 NM_004458 Acyl-CoA synthetase long-chain family member 4 4.02 
    1522656 LDLR NM_000527 Low-density lipoprotein receptor 3.63 
    1538541 DHRS9 NM_005771 Dehydrogenase/reductase (SDR family) member 9 3.55 
    1514810 ATP1A3 NM_152296 ATPase, Na+/K+ transporting, alpha 3 polypeptide 3.53 
    1524666 FABP5 NM_001444 Fatty acid binding protein 5 (psoriasis-associated) 3.38 
    1538372 ATP1A1 NM_000701 ATPase, Na+/K+ transporting, alpha 1 polypeptide 3.38 
    1524650 GNS NM_002076 Glucosamine (N-acetyl)-6- 3.37 
    1523432 ACSL1 NM_001995 Acyl-CoA synthetase long-chain family member 1 3.35 
    1529572 SGSH NM_000199 N-sulfoglucosamine sulfohydrolase (sulfamidase) 3.29 
    1538734 ACSL3 NM_004457 Acyl-CoA synthetase long-chain family member 3 3.27 
    1985998 ALOX5 BQ548663 Arachidonate 5-lipoxygenase 3.16 
    1527407 GAPDH NM_002046 Glyceraldehyde3-phosphate dehydrogenase 3.16 
    1534240 SULT1B1 D89479 Sulfotransferase family, cytosolic, 1B, member 1 3.10 
    1983183 NDUFB6 NM_182739 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 −3.10 
    1525237 ALDH6A1 NM_005589 Aldehyde dehydrogenase 6 family, member A1 −3.22 
    1518778 ALOX15 NM_001140 Arachidonate 15-lipoxygenase −3.24 
    1523761 CBR1 NM_001757 Carbonyl reductase 1 −3.61 
    1510672 MCCC1 NM_020166 Methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) −4.01 
    1990453 NDUFV2 BI520375 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa −4.31 
    1521732 ATP12A NM_001676 ATPase, H+/K+ transporting, nongastric, alpha polypeptide −4.74 
    1526184 LDHB NM_002300 Lactate dehydrogenase B −6.08 
    1512448 ISOC1 NM_016048 Isochorismatase domain containing 1 −6.51 
    1989369 METTL7A BC004492 Methyltransferase like 7A −6.99 
    1518627 FA2H NM_024306 Fatty acid 2-hydroxylase −7.75 
    1506804 PLD4 NM_138790 Phospholipase D family, member 4 −9.53 
    1521949 SORD NM_003104 Sorbitol dehydrogenase −10.20 
    1512822 SULF2 NM_018837 Sulfatase 2 −21.22 

Genes that were found to be differentially expressed after in vivo treatment with G-CSF-dexamethasone were analyzed with use of the OntoExpress program (http://vortex.cs.wayne.edu/projects.htm#Onto-Express), and categorized into functional profiles. The majority of analyzed genes are categorized into 6 main functional categories: transcription, signal transduction, immune response, cell faith & apoptosis, cell adhesion and mobility, and metabolism. Results are presented as the mean fold-increase or -decrease of 3 separate donors (comparison is with freshly isolated neutrophils t = 0).

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