Summary of hemophilia B dogs undergoing AAV-mediated gene therapy
| Dog . | Age* . | Rx . | Bleed frequency . | Inhibitor status . | Outcome . |
|---|---|---|---|---|---|
| Kudzu | NA | None | 6/3.6 y | − | Alive/B |
| Brad | 9 mo | Liver | 0/6.25 y | − | Alive/N |
| Semillon | 5.5 mo | Liver | 0/5.9 y | − | Alive/N |
| Beech | 12 mo | Liver | 1/11 wk | + | Dead/FB |
| Sauvignon | 5.5 mo | Muscle | 6/5.9 y | + | Alive/B |
| Wilbur | 8.5 y | Muscle | 8/6.0 y | + | Alive/B |
| Wes | 9 mo | Muscle | 10/2.4 y | + | Dead/FB |
| Dog . | Age* . | Rx . | Bleed frequency . | Inhibitor status . | Outcome . |
|---|---|---|---|---|---|
| Kudzu | NA | None | 6/3.6 y | − | Alive/B |
| Brad | 9 mo | Liver | 0/6.25 y | − | Alive/N |
| Semillon | 5.5 mo | Liver | 0/5.9 y | − | Alive/N |
| Beech | 12 mo | Liver | 1/11 wk | + | Dead/FB |
| Sauvignon | 5.5 mo | Muscle | 6/5.9 y | + | Alive/B |
| Wilbur | 8.5 y | Muscle | 8/6.0 y | + | Alive/B |
| Wes | 9 mo | Muscle | 10/2.4 y | + | Dead/FB |
NA indicates not applicable; N, normal clotting; B, abnormal clotting; FB, fatal bleed; mo, months; y, years; and wk, weeks.
Age at vector administration.