Table 2 Inhibition of fibrinogen binding... | American Society of Hematology

Table 2

Inhibition of fibrinogen binding to human recombinant WT αIIbβ3 and to recombinant human αIIbβ3 containing a chimeric human/rat α subunit by echistatin and eristostatin

	WT human αIIbβ3	Human αIIbβ3 + αIIb D²³²H	Human αIIbβ3 + rat αIIb W3:4-1/W4:4-1
IC₅₀ for inhibiting fibrinogen binding to αIIbβ3, nM*
Echistatin	29.2	298.9	1.09 × 10⁶
Erisostatin	100.9	283.1	5.23 × 10⁴
Relative IC₅₀ for inhibiting fibrinogen binding to αIIbβ3†
Echistatin	1	10.2	3.7 × 10⁴
Erisostatin	1	2.8	519

	WT human αIIbβ3	Human αIIbβ3 + αIIb D²³²H	Human αIIbβ3 + rat αIIb W3:4-1/W4:4-1
IC₅₀ for inhibiting fibrinogen binding to αIIbβ3, nM*
Echistatin	29.2	298.9	1.09 × 10⁶
Erisostatin	100.9	283.1	5.23 × 10⁴
Relative IC₅₀ for inhibiting fibrinogen binding to αIIbβ3†
Echistatin	1	10.2	3.7 × 10⁴
Erisostatin	1	2.8	519

IC₅₀ were calculated from the equations from the trend lines shown in Figure 4.

†

IC₅₀ were normalized to fibrinogen binding to wild-type human αIIbβ3.

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