Design of studies included in the systematic review
| Study . | Country . | Study design . | Type of data reported for H pylori–positive patients . | No. of ITP patients . | Diagnostic tests for H pylori infection . |
|---|---|---|---|---|---|
| Gasbarrini et al (1998)2 | Italy | Observational, case series, single center | Group | 18 | UBT |
| Jarque et al (2001)18 | Spain | Observational, case series, single center | Group | 56 | UBT |
| Kohda et al (2002)19 | Japan | Observational, case series, single center | Group | 40 | UBT/RUT/His/Ab |
| Hino et al (2003)20 | Japan | Observational, case series, single center | Individual | 30 | UBT/Ab |
| Hashino et al (2003)21 | Japan | Observational, case series, single center | Individual | 22 | UBT/RUT/His/Cul |
| Ando et al (2003)22 | Japan | Observational, case series, single center | Individual | 61 | UBT |
| Michel et al (2004)23 | US | Observational, case series, single center | Group and individual | 74 | UBT |
| Takahashi et al (2004)24 | Japan | Observational, case series, single center | Individual | 20 | UBT |
| Sato et al (2004)25 | Japan | Observational, case series, single center | Group | 53 | UBT |
| Ando et al (2004)26 | Japan | Observational, case series, single center | Group | 20 | UBT/Ab |
| Nomura et al (2004)27 | Japan | Observational, case series, single center | Group | 42 | UBT |
| Veneri et al (2005)28 | Italy | Observational, case series, single center | Group | 52 | UBT |
| Inaba et al (2005)29 | Japan | Observational, case series, multicenter | Group | 35 | UBT/Ab |
| Stasi et al (2005)30 | Italy-United Kingdom | Observational, case series, multicenter | Group and individual | 137 | UBT |
| Fujimura et al (2005)39 | Japan | Retrospective, case series, multicenter | Group | 435 | UBT |
| Suzuki et al (2005)17 | Japan | Randomized, phase 3, single center | Group | 36 | UBT/His |
| Suvajdzić et al (2006)31 | Serbia | Observational, case series, single center | Group | 54 | UBT |
| Ahn et al (2006)32 | US | Observational, case series, single center | Individual | 15 | UBT |
| Sayan et al (2006)33 | Turkey | Observational, case series, single center | Individual | 34 | UBT |
| Asahi et al (2006)34 | Japan | Observational, case series, single center | Group | 37 | UBT ± Ab/SAT |
| Kodama et al (2007)35 | Japan | Observational, case series, single center | Group | 116 | UBT |
| Campuzano-Maya (2007)40 | Colombia | Retrospective, case series, single center | Group | 32 | UBT |
| Estrada-Gómez et al (2007)36 | Mexico | Observational, case series, single center | Group | 23 | SAT |
| Satake et al (2007)37 | Japan | Observational, case series, single center | Group | 38 | UBT or RUT |
| Emilia et al (2007)38 | Italy | Observational, case series, single center | Individual | 75 | UBT ± His |
| Study . | Country . | Study design . | Type of data reported for H pylori–positive patients . | No. of ITP patients . | Diagnostic tests for H pylori infection . |
|---|---|---|---|---|---|
| Gasbarrini et al (1998)2 | Italy | Observational, case series, single center | Group | 18 | UBT |
| Jarque et al (2001)18 | Spain | Observational, case series, single center | Group | 56 | UBT |
| Kohda et al (2002)19 | Japan | Observational, case series, single center | Group | 40 | UBT/RUT/His/Ab |
| Hino et al (2003)20 | Japan | Observational, case series, single center | Individual | 30 | UBT/Ab |
| Hashino et al (2003)21 | Japan | Observational, case series, single center | Individual | 22 | UBT/RUT/His/Cul |
| Ando et al (2003)22 | Japan | Observational, case series, single center | Individual | 61 | UBT |
| Michel et al (2004)23 | US | Observational, case series, single center | Group and individual | 74 | UBT |
| Takahashi et al (2004)24 | Japan | Observational, case series, single center | Individual | 20 | UBT |
| Sato et al (2004)25 | Japan | Observational, case series, single center | Group | 53 | UBT |
| Ando et al (2004)26 | Japan | Observational, case series, single center | Group | 20 | UBT/Ab |
| Nomura et al (2004)27 | Japan | Observational, case series, single center | Group | 42 | UBT |
| Veneri et al (2005)28 | Italy | Observational, case series, single center | Group | 52 | UBT |
| Inaba et al (2005)29 | Japan | Observational, case series, multicenter | Group | 35 | UBT/Ab |
| Stasi et al (2005)30 | Italy-United Kingdom | Observational, case series, multicenter | Group and individual | 137 | UBT |
| Fujimura et al (2005)39 | Japan | Retrospective, case series, multicenter | Group | 435 | UBT |
| Suzuki et al (2005)17 | Japan | Randomized, phase 3, single center | Group | 36 | UBT/His |
| Suvajdzić et al (2006)31 | Serbia | Observational, case series, single center | Group | 54 | UBT |
| Ahn et al (2006)32 | US | Observational, case series, single center | Individual | 15 | UBT |
| Sayan et al (2006)33 | Turkey | Observational, case series, single center | Individual | 34 | UBT |
| Asahi et al (2006)34 | Japan | Observational, case series, single center | Group | 37 | UBT ± Ab/SAT |
| Kodama et al (2007)35 | Japan | Observational, case series, single center | Group | 116 | UBT |
| Campuzano-Maya (2007)40 | Colombia | Retrospective, case series, single center | Group | 32 | UBT |
| Estrada-Gómez et al (2007)36 | Mexico | Observational, case series, single center | Group | 23 | SAT |
| Satake et al (2007)37 | Japan | Observational, case series, single center | Group | 38 | UBT or RUT |
| Emilia et al (2007)38 | Italy | Observational, case series, single center | Individual | 75 | UBT ± His |
The H pylorieradication regimen consisted of a proton pump inhibitor, clarithromycin, and amoxicillin in all of the studies; however, bismuth subsalicylate was added to this combination in the study by Estrada-Gomez et al36 performed in Mexico.
UBT indicates 13C-urea breath test; RUT, rapid urease test; His, histopatological examination; Ab, serum antibodies; Cul, culture; and SAT, stool antigen test.