Initial characteristics of patients with and without differentiation syndrome (DS)
| Characteristic . | DS . | No DS . | P . | Total . | |||
|---|---|---|---|---|---|---|---|
| Median (range) . | No. (%) . | Median (range) . | No. (%) . | Median (range) . | No. (%) . | ||
| Overall | 183 (100) | 556 (100) | 739 (100) | ||||
| Protocol | |||||||
| LPA96 | 53 (29) | 122 (22) | .05 | 175 (24) | |||
| LPA99 | 130 (71) | 434 (78) | 564 (76) | ||||
| Age, y | 43 (3-78) | 39 (2-83) | .04 | 40 (2-83) | |||
| Younger than 19 | 17 (9) | 67 (12) | 84 (11) | ||||
| 19-50 | 103 (56) | 326 (58) | 429 (58) | ||||
| 51-60 | 24 (13) | 71 (13) | 95 (13) | ||||
| 61-70 | 24 (13) | 63 (11) | 87 (12) | ||||
| Older than 70 | 15 (8) | 29 (5) | 44 (6) | ||||
| Sex | |||||||
| Male | 100 (55) | 274 (49) | .21 | 374 (51) | |||
| Female | 83 (45) | 282 (51) | 365 (49) | ||||
| ECOG performance status | 1 (0-3) | 1 (0-3) | .32 | 1 (0-3) | |||
| 0-1 | 123 (72) | 389 (76) | 512 (75) | ||||
| 2 | 37 (22) | 86 (17) | 123 (18) | ||||
| 3 | 10 (6) | 36 (7) | 46 (7) | ||||
| Fever | |||||||
| No | 109 (60) | 338 (61) | .71 | 447 (61) | |||
| Yes | 73 (40) | 212 (38) | 285 (39) | ||||
| WBC count, ×109/L | 3.3 (0.4-133) | 2.0 (0.2-460) | <.001 | 2.2 (0.2-460) | |||
| Less than 2 | 69 (38) | 281 (51) | 350 (47) | ||||
| 2-5 | 35 (19) | 105 (19) | 140 (19) | ||||
| 5-10 | 16 (9) | 46 (8) | 62 (8) | ||||
| 10-50 | 48 (26) | 85 (15) | 133 (18) | ||||
| More than 50 | 15 (8) | 38 (7) | 53 (7) | ||||
| Platelet count, ×109/L | 20 (1-207) | 23 (1-207) | .19 | 22 (1-207) | |||
| Less than 10 | 32 (17) | 102 (18) | 134 (18) | ||||
| 10-40 | 116 (59) | 318 (67) | 434 (59) | ||||
| More than 40 | 35 (19) | 135 (24) | 170 (23) | ||||
| Hemoglobin, g/dL | 9.5 (4-16.9) | 9.0 (3-15.9) | .12 | 9.3 (3-16.9) | |||
| Less than or equal to 10 | 112 (61) | 357 (64) | 469 (64) | ||||
| More than 10 | 71 (39) | 198 (36) | 269 (36) | ||||
| Creatinine, mg/dL | 1.0 (0.2-2) | 0.9 (0.2-2.4) | .03 | 0.9 (0.2-2.4) | |||
| Less than or equal to 1.4 | 170 (96) | 532 (99) | 702 (98) | ||||
| More than 1.4 | 7 (4) | 7 (1) | 14 (2) | ||||
| Albumin, mg/dL | 4.0 (2.3-6.7) | 4.0 (1.7-6.2) | .99 | 4.0 (1.7-6.7) | |||
| Less than or equal to 3.5 | 34 (23) | 93 (21) | 127 (21) | ||||
| More than 3.5 | 134 (77) | 356 (79) | 470 (79) | ||||
| Coagulopathy | |||||||
| No | 31 (17) | 140 (25) | .02 | 171 (23) | |||
| Yes | 151 (83) | 412 (75) | 563 (77) | ||||
| FAB subtype | |||||||
| Hypergranular | 143 (78) | 455 (83) | .11 | 598 (82) | |||
| Microgranular | 40 (22) | 91 (17) | 131 (18) | ||||
| PML-RARA isoform | |||||||
| BCR1/BCR2 | 90 (55) | 292 (59) | .35 | 382 (58) | |||
| BCR3 | 73 (45) | 200 (41) | 271 (42) | ||||
| Characteristic . | DS . | No DS . | P . | Total . | |||
|---|---|---|---|---|---|---|---|
| Median (range) . | No. (%) . | Median (range) . | No. (%) . | Median (range) . | No. (%) . | ||
| Overall | 183 (100) | 556 (100) | 739 (100) | ||||
| Protocol | |||||||
| LPA96 | 53 (29) | 122 (22) | .05 | 175 (24) | |||
| LPA99 | 130 (71) | 434 (78) | 564 (76) | ||||
| Age, y | 43 (3-78) | 39 (2-83) | .04 | 40 (2-83) | |||
| Younger than 19 | 17 (9) | 67 (12) | 84 (11) | ||||
| 19-50 | 103 (56) | 326 (58) | 429 (58) | ||||
| 51-60 | 24 (13) | 71 (13) | 95 (13) | ||||
| 61-70 | 24 (13) | 63 (11) | 87 (12) | ||||
| Older than 70 | 15 (8) | 29 (5) | 44 (6) | ||||
| Sex | |||||||
| Male | 100 (55) | 274 (49) | .21 | 374 (51) | |||
| Female | 83 (45) | 282 (51) | 365 (49) | ||||
| ECOG performance status | 1 (0-3) | 1 (0-3) | .32 | 1 (0-3) | |||
| 0-1 | 123 (72) | 389 (76) | 512 (75) | ||||
| 2 | 37 (22) | 86 (17) | 123 (18) | ||||
| 3 | 10 (6) | 36 (7) | 46 (7) | ||||
| Fever | |||||||
| No | 109 (60) | 338 (61) | .71 | 447 (61) | |||
| Yes | 73 (40) | 212 (38) | 285 (39) | ||||
| WBC count, ×109/L | 3.3 (0.4-133) | 2.0 (0.2-460) | <.001 | 2.2 (0.2-460) | |||
| Less than 2 | 69 (38) | 281 (51) | 350 (47) | ||||
| 2-5 | 35 (19) | 105 (19) | 140 (19) | ||||
| 5-10 | 16 (9) | 46 (8) | 62 (8) | ||||
| 10-50 | 48 (26) | 85 (15) | 133 (18) | ||||
| More than 50 | 15 (8) | 38 (7) | 53 (7) | ||||
| Platelet count, ×109/L | 20 (1-207) | 23 (1-207) | .19 | 22 (1-207) | |||
| Less than 10 | 32 (17) | 102 (18) | 134 (18) | ||||
| 10-40 | 116 (59) | 318 (67) | 434 (59) | ||||
| More than 40 | 35 (19) | 135 (24) | 170 (23) | ||||
| Hemoglobin, g/dL | 9.5 (4-16.9) | 9.0 (3-15.9) | .12 | 9.3 (3-16.9) | |||
| Less than or equal to 10 | 112 (61) | 357 (64) | 469 (64) | ||||
| More than 10 | 71 (39) | 198 (36) | 269 (36) | ||||
| Creatinine, mg/dL | 1.0 (0.2-2) | 0.9 (0.2-2.4) | .03 | 0.9 (0.2-2.4) | |||
| Less than or equal to 1.4 | 170 (96) | 532 (99) | 702 (98) | ||||
| More than 1.4 | 7 (4) | 7 (1) | 14 (2) | ||||
| Albumin, mg/dL | 4.0 (2.3-6.7) | 4.0 (1.7-6.2) | .99 | 4.0 (1.7-6.7) | |||
| Less than or equal to 3.5 | 34 (23) | 93 (21) | 127 (21) | ||||
| More than 3.5 | 134 (77) | 356 (79) | 470 (79) | ||||
| Coagulopathy | |||||||
| No | 31 (17) | 140 (25) | .02 | 171 (23) | |||
| Yes | 151 (83) | 412 (75) | 563 (77) | ||||
| FAB subtype | |||||||
| Hypergranular | 143 (78) | 455 (83) | .11 | 598 (82) | |||
| Microgranular | 40 (22) | 91 (17) | 131 (18) | ||||
| PML-RARA isoform | |||||||
| BCR1/BCR2 | 90 (55) | 292 (59) | .35 | 382 (58) | |||
| BCR3 | 73 (45) | 200 (41) | 271 (42) | ||||