Nomenclature of bsAb constructs made by DNL
| . | CH3-AD2-IgG module . | CH1-Fab-DDD2 module . |
|---|---|---|
| 22-20 | CH3-AD2-IgG-e-mab | CH1-DDD2-Fab-v-mab |
| 20-22 | CH3-AD2-IgG-v-mab | CH1-DDD2-Fab-e-mab |
| 20-14 | CH3-AD2-IgG-v-mab | CH1-DDD2-Fab-hMN-14 |
| 734-20 | CH3-AD2-IgG-h734 | CH1-DDD2-Fab-v-mab |
| 20-20 | CH3-AD2-IgG-v-mab | CH1-DDD2-Fab-v-mab |
| 22-22 | CH3-AD2-IgG-e-mab | CH1-DDD2-Fab-e-mab |
| . | CH3-AD2-IgG module . | CH1-Fab-DDD2 module . |
|---|---|---|
| 22-20 | CH3-AD2-IgG-e-mab | CH1-DDD2-Fab-v-mab |
| 20-22 | CH3-AD2-IgG-v-mab | CH1-DDD2-Fab-e-mab |
| 20-14 | CH3-AD2-IgG-v-mab | CH1-DDD2-Fab-hMN-14 |
| 734-20 | CH3-AD2-IgG-h734 | CH1-DDD2-Fab-v-mab |
| 20-20 | CH3-AD2-IgG-v-mab | CH1-DDD2-Fab-v-mab |
| 22-22 | CH3-AD2-IgG-e-mab | CH1-DDD2-Fab-e-mab |
Each construct is composed of 2 Fabs of the specificity indicated preceding the dash and 4 Fabs of the specificity indicated after the dash.
20 indicates anti-CD20; 22, anti-CD22; 14, anti-CEACAM5; and 734, anti-In-DTPA.