Recurrent copy number changes targeting the miRNA genome in DLBCL
| MicroRNA ID . | Chromosome . | Size, kb . | No. of probes . | Abnormal patients, % . |
|---|---|---|---|---|
| Copy number gain | ||||
| miR-513-1,* miR-513-2,* miR-506, miR-507, miR-508, miR-509, miR-510, miR-514-1, miR-514 | X | 105 | 194 | 24.7 |
| miR-105-1, miR-767, miR-105-2 | X | 36 | 90 | 24.7 |
| miR-17,* miR-18a,* miR-19a,* miR-20a,* miR-19b-1,* miR-92-1* | 13 | 34 | 133 | 24.7 |
| miR-224, miR-452 | X | 35 | 129 | 23.3 |
| miR-504 | X | 34 | 130 | 21.9 |
| miR-363, miR-92-2,* miR-19b-2,* miR-20b,*miR-18b, miR-106a* | X | 34 | 130 | 21.9 |
| miR-221, miR-222* | X | 34 | 106 | 20.5 |
| miR-450-1, miR-450-2, miR-542, miR-503, miR-424* | X | 40 | 132 | 20.5 |
| miR-505 | X | 34 | 91 | 20.5 |
| miR-532, miR-188,* miR-500, miR-362, miR-501, miR-660, miR-502 | X | 45 | 114 | 20.5 |
| miR-98, let-7f-2* | X | 35 | 139 | 20.5 |
| miR-653, miR-489 | 7 | 35 | 160 | 20.5 |
| miR-148b | 12 | 34 | 118 | 20.5 |
| miR-570 | 3 | 34 | 38 | 19.2 |
| miR-421 | X | 34 | 98 | 19.2 |
| miR-545, miR-374* | X | 34 | 123 | 19.2 |
| miR-223* | X | 34 | 128 | 19.2 |
| Copy number loss | ||||
| miR-650 | 22 | 34 | 78 | 31.5 |
| miR-31 | 9 | 34 | 118 | 17.8 |
| miR-588 | 6 | 34 | 61 | 17.8 |
| miR-548a-2 | 6 | 34 | 127 | 17.8 |
| miR-548b | 6 | 34 | 113 | 15.1 |
| miR-570 | 3 | 34 | 38 | 13.7 |
| miR-16-1,* miR-15a* | 13 | 34 | 121 | 13.7 |
| miR-596 | 8 | 34 | 69 | 13.7 |
| miR-587 | 6 | 34 | 110 | 12.3 |
| miR-491 | 9 | 34 | 134 | 11 |
| miR-124a-1 | 8 | 34 | 112 | 11 |
| MicroRNA ID . | Chromosome . | Size, kb . | No. of probes . | Abnormal patients, % . |
|---|---|---|---|---|
| Copy number gain | ||||
| miR-513-1,* miR-513-2,* miR-506, miR-507, miR-508, miR-509, miR-510, miR-514-1, miR-514 | X | 105 | 194 | 24.7 |
| miR-105-1, miR-767, miR-105-2 | X | 36 | 90 | 24.7 |
| miR-17,* miR-18a,* miR-19a,* miR-20a,* miR-19b-1,* miR-92-1* | 13 | 34 | 133 | 24.7 |
| miR-224, miR-452 | X | 35 | 129 | 23.3 |
| miR-504 | X | 34 | 130 | 21.9 |
| miR-363, miR-92-2,* miR-19b-2,* miR-20b,*miR-18b, miR-106a* | X | 34 | 130 | 21.9 |
| miR-221, miR-222* | X | 34 | 106 | 20.5 |
| miR-450-1, miR-450-2, miR-542, miR-503, miR-424* | X | 40 | 132 | 20.5 |
| miR-505 | X | 34 | 91 | 20.5 |
| miR-532, miR-188,* miR-500, miR-362, miR-501, miR-660, miR-502 | X | 45 | 114 | 20.5 |
| miR-98, let-7f-2* | X | 35 | 139 | 20.5 |
| miR-653, miR-489 | 7 | 35 | 160 | 20.5 |
| miR-148b | 12 | 34 | 118 | 20.5 |
| miR-570 | 3 | 34 | 38 | 19.2 |
| miR-421 | X | 34 | 98 | 19.2 |
| miR-545, miR-374* | X | 34 | 123 | 19.2 |
| miR-223* | X | 34 | 128 | 19.2 |
| Copy number loss | ||||
| miR-650 | 22 | 34 | 78 | 31.5 |
| miR-31 | 9 | 34 | 118 | 17.8 |
| miR-588 | 6 | 34 | 61 | 17.8 |
| miR-548a-2 | 6 | 34 | 127 | 17.8 |
| miR-548b | 6 | 34 | 113 | 15.1 |
| miR-570 | 3 | 34 | 38 | 13.7 |
| miR-16-1,* miR-15a* | 13 | 34 | 121 | 13.7 |
| miR-596 | 8 | 34 | 69 | 13.7 |
| miR-587 | 6 | 34 | 110 | 12.3 |
| miR-491 | 9 | 34 | 134 | 11 |
| miR-124a-1 | 8 | 34 | 112 | 11 |
Chr indicates chromosome ID; size, area (in kilobases) surrounding the miRNA precursor sequence that was tiled with the oligonucleotide probes; no. of probes, total number of probes tiling each locus; abnormal patients, percentage of cases, of 73 samples, with disruption of the indicated miRNA locus.
miRNAs also included in the expression signatures displayed in Figure 2.