Changes from baseline to day 4 in percentage of cycling (Ki67+) T-cell subsets (median values with IQR in parentheses)
| Percentage Ki67+ expression . | rhIL-7, n = 18 . | Placebo, n = 6 . | P . |
|---|---|---|---|
| Naive CD4+ T cells | +2.98 (+2.39, +6.44) | 0.00 (−0.08, +0.08) | < .001 |
| Central memory CD4+ T cells | +9.98 (+6.70, +12.68) | +0.29 (0.06, +0.66) | < .001 |
| Effector CD4+ T cells | +10.92 (+5.78, +16.41) | −0.21 (−0.61, +0.35) | < .001 |
| CD45RO− effector CD4+ T cells | +9.90 (+6.81, +19.60) | −0.17 (0.55, +0.12) | < .001 |
| CD127+ CD4+ T cells | +9.84 (+6.91, +15.37) | −0.18 (−0.18, −0.04) | < .001 |
| CD127− CD4+ T cells | +0.59 (−1.90, +2.17) | +1.20 (−0.05, +2.46) | .590 |
| CD25highCD127low CD4+ T cells | +0.57 (−2.03, +1.29) | +1.30 (+0.51, +1.90) | .300 |
| Naive CD8+ T cells | +10.58 (+8.38, +25.24) | 0.00 (−0.06, +0.06) | < .001 |
| Central memory CD8+ T cells | +8.98 (+6.85, +16.48) | +0.12 (−0.05, +0.28) | < .001 |
| Effector CD8+ T cells | +8.49 (+5.14, +12.36) | +0.14 (−0.13, +0.37) | < .001 |
| CD45RO− effector CD8+ T cells | +6.56 (+3.27, +11.57) | +0.15 (+0.07, +0.03) | < .001 |
| CD127+ CD8+ T cells | +13.46 (+10.07, +21.11) | +0.01 (−0.08, +010) | < .001 |
| CD127− CD8+ T cells | +3.18 (+1.43, +5.37) | +0.31 (+0.02, +0.58) | .006 |
| Percentage Ki67+ expression . | rhIL-7, n = 18 . | Placebo, n = 6 . | P . |
|---|---|---|---|
| Naive CD4+ T cells | +2.98 (+2.39, +6.44) | 0.00 (−0.08, +0.08) | < .001 |
| Central memory CD4+ T cells | +9.98 (+6.70, +12.68) | +0.29 (0.06, +0.66) | < .001 |
| Effector CD4+ T cells | +10.92 (+5.78, +16.41) | −0.21 (−0.61, +0.35) | < .001 |
| CD45RO− effector CD4+ T cells | +9.90 (+6.81, +19.60) | −0.17 (0.55, +0.12) | < .001 |
| CD127+ CD4+ T cells | +9.84 (+6.91, +15.37) | −0.18 (−0.18, −0.04) | < .001 |
| CD127− CD4+ T cells | +0.59 (−1.90, +2.17) | +1.20 (−0.05, +2.46) | .590 |
| CD25highCD127low CD4+ T cells | +0.57 (−2.03, +1.29) | +1.30 (+0.51, +1.90) | .300 |
| Naive CD8+ T cells | +10.58 (+8.38, +25.24) | 0.00 (−0.06, +0.06) | < .001 |
| Central memory CD8+ T cells | +8.98 (+6.85, +16.48) | +0.12 (−0.05, +0.28) | < .001 |
| Effector CD8+ T cells | +8.49 (+5.14, +12.36) | +0.14 (−0.13, +0.37) | < .001 |
| CD45RO− effector CD8+ T cells | +6.56 (+3.27, +11.57) | +0.15 (+0.07, +0.03) | < .001 |
| CD127+ CD8+ T cells | +13.46 (+10.07, +21.11) | +0.01 (−0.08, +010) | < .001 |
| CD127− CD8+ T cells | +3.18 (+1.43, +5.37) | +0.31 (+0.02, +0.58) | .006 |