PK data from 30 minutes to 72 hours after injection (median values)
| . | Dose, μg . | Cmax, pg/mL . | Tmax, h . | AUC, pg ∙ min/mL . | T1/2, h . | Clearance, mL/min . |
|---|---|---|---|---|---|---|
| 3 μg/kg (stratum 1) | 245.4 | 104.00 | 4 | 61112 | 13.24 | 4015.59 |
| 3 μg/kg (stratum 2) | 251.7 | 53.80 | 2.5 | 32741 | 23.30 | 7687.72 |
| 10 μg/kg (stratum 1) | 632 | 475.10 | 4 | 273890 | 10.44 | 2307.50 |
| 10 μg/kg (stratum 2) | 666 | 191.40 | 4 | 140255 | 11.86 | 4748.49 |
| 30 μg/kg (stratum 1) | 2225 | 1683.70 | 4 | 974058 | 7.89 | 2283.75 |
| 60 μg/kg (stratum 1) | 4446 | 3603.30 | 4 | 2628060 | 7.64 | 1691.74 |
| . | Dose, μg . | Cmax, pg/mL . | Tmax, h . | AUC, pg ∙ min/mL . | T1/2, h . | Clearance, mL/min . |
|---|---|---|---|---|---|---|
| 3 μg/kg (stratum 1) | 245.4 | 104.00 | 4 | 61112 | 13.24 | 4015.59 |
| 3 μg/kg (stratum 2) | 251.7 | 53.80 | 2.5 | 32741 | 23.30 | 7687.72 |
| 10 μg/kg (stratum 1) | 632 | 475.10 | 4 | 273890 | 10.44 | 2307.50 |
| 10 μg/kg (stratum 2) | 666 | 191.40 | 4 | 140255 | 11.86 | 4748.49 |
| 30 μg/kg (stratum 1) | 2225 | 1683.70 | 4 | 974058 | 7.89 | 2283.75 |
| 60 μg/kg (stratum 1) | 4446 | 3603.30 | 4 | 2628060 | 7.64 | 1691.74 |