Table 3

Comparison of clinical variables at presentation between WT and mutant TET2*

Variable†TET2 mutantTET2 WTP
Age (n = 60)    
    ≥ 60 y 17 31 .21 
    < 60 y 2 10  
Sex‡ (n = 61)    
    Male 18 24 .003 
    Female 1 18  
Hemoglobin§ (n = 61)    
    ≥ 10 g/dL 7 22 .38 
    < 10 g/dL 11 21  
WBC count (n = 61)    
    ≥ 10 × 109/L 13 12 .01 
    < 10 × 109/L 8 28  
Platelet count (n = 62)    
    ≥ 450 × 109/L 1 3 .65 
    150-450 × 109/L 5 7  
    < 150 × 109/L 13 33  
Absolute monocyte count (n = 62)    
    ≥ 1 × 109/L 12 15 .03 
    < 1 × 109/L 7 28  
Number of cytopenias (n = 61)    
    0 4 6 .74 
    1 5 16  
    2 7 14  
    3 2 7  
Palpable splenomegaly (n = 62)    
    Yes 9 19 .82 
    No 10 24  
Metaphase cytogenetics§ (n = 60)    
    Normal 11 12 .07 
    Abnormal 8 24  
Bone marrow blasts§ (n = 61)    
    ≥ 5% 6 21 .17 
    < 5% 13 21  
Bone marrow cellularity (n = 56)    
    Hypercellular 16 28 .44 
    Normocellular 3 6  
    Hypocellular 0 3  
No. dysplastic BM cell lines (n = 59)    
    0 5 18 .09 
    1 7 4  
    2 4 10  
    3 3 8  
Bone marrow megakaryocytes (n = 57)    
    Dysplastic 10 22 .94 
    Normal 8 17  
Progression to AML (n = 62)    
    Yes 14 21 .06 
    No 5 22  
Variable†TET2 mutantTET2 WTP
Age (n = 60)    
    ≥ 60 y 17 31 .21 
    < 60 y 2 10  
Sex‡ (n = 61)    
    Male 18 24 .003 
    Female 1 18  
Hemoglobin§ (n = 61)    
    ≥ 10 g/dL 7 22 .38 
    < 10 g/dL 11 21  
WBC count (n = 61)    
    ≥ 10 × 109/L 13 12 .01 
    < 10 × 109/L 8 28  
Platelet count (n = 62)    
    ≥ 450 × 109/L 1 3 .65 
    150-450 × 109/L 5 7  
    < 150 × 109/L 13 33  
Absolute monocyte count (n = 62)    
    ≥ 1 × 109/L 12 15 .03 
    < 1 × 109/L 7 28  
Number of cytopenias (n = 61)    
    0 4 6 .74 
    1 5 16  
    2 7 14  
    3 2 7  
Palpable splenomegaly (n = 62)    
    Yes 9 19 .82 
    No 10 24  
Metaphase cytogenetics§ (n = 60)    
    Normal 11 12 .07 
    Abnormal 8 24  
Bone marrow blasts§ (n = 61)    
    ≥ 5% 6 21 .17 
    < 5% 13 21  
Bone marrow cellularity (n = 56)    
    Hypercellular 16 28 .44 
    Normocellular 3 6  
    Hypocellular 0 3  
No. dysplastic BM cell lines (n = 59)    
    0 5 18 .09 
    1 7 4  
    2 4 10  
    3 3 8  
Bone marrow megakaryocytes (n = 57)    
    Dysplastic 10 22 .94 
    Normal 8 17  
Progression to AML (n = 62)    
    Yes 14 21 .06 
    No 5 22  
*

Q1084P and Y86H SNPs are excluded (see “Note added in proof”).

†

Some clinical data are not available.

‡

Median WBC count for TET2 mutant is 18 × 109/L and for TET2 wild-type is 6 × 109/L.

§

Median platelet count for TET2 mutant is 72 × 109/L and for TET2 wild-type is 88 × 109/L.

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