ADAMTS-18 385-AA fragment given 2 hours before or after obstruction of right middle cerebral artery and examined 8 days after removal of obstruction
| . | No. . | % Infarct . | Postural reflex* . | Rotor rod† . | Transverse beam† . |
|---|---|---|---|---|---|
| 385AA | 13 | 23.9 ± 4.0 | 1.02 ± 0.17 | 4.62 ± 0.58 | 5.97 ± 0.48 |
| 66AA+ | 8 | 43.8 ± 7.3 | 2.87 ± 0.13 | 3.23 ± 0.45 | 3.87 ± 0.90 |
| Saline | 14 | 43.0 ± 4.8 | 2.31 ± 0.25 | 3.19 ± 0.34 | 4.52 ± 0.46 |
| P§ | < .001 | < .002 | < .04 | < .01 |
| . | No. . | % Infarct . | Postural reflex* . | Rotor rod† . | Transverse beam† . |
|---|---|---|---|---|---|
| 385AA | 13 | 23.9 ± 4.0 | 1.02 ± 0.17 | 4.62 ± 0.58 | 5.97 ± 0.48 |
| 66AA+ | 8 | 43.8 ± 7.3 | 2.87 ± 0.13 | 3.23 ± 0.45 | 3.87 ± 0.90 |
| Saline | 14 | 43.0 ± 4.8 | 2.31 ± 0.25 | 3.19 ± 0.34 | 4.52 ± 0.46 |
| P§ | < .001 | < .002 | < .04 | < .01 |
Higher number reflects greater neurologic damage.
Lower number reflects greater neurologic damage.
Student t test comparison of intravenous injections of saline vehicle versus 35 μg ADAMTS-18 385-AA fragment versus functionally inactive ADAMTS-18 66-AA fragment (control). Since differences were not noted between pre– and post–ADAMTS-18 385-AA fragment infusion, both groups were averaged.