Table 4 Hematologic and nonhematologic... | American Society of Hematology

Table 4

Hematologic and nonhematologic adverse events related to ezatiostat tablets in 5% or more of patients: by dose level

Adverse event (preferred term)	Dose level, mg, n (%)
	N = 3						N = 4	N = 5	N = 6	N = 12
	200	400	1000	1400	2000	2400	3000	4000	5000	6000
Hematologic
Neutropenia	0	0	0	0	0	0	1 (25)	1 (20)	0	1 (8)
Nonhematologic
Nausea	1 (33)	0	0	3 (100)	2 (67)	2 (67)	2 (50)	3 (60)	5 (83)	11 (92)
Diarrhea	0	0	1 (33)	1 (33)	1 (33)	0	2 (50)	3 (60)	3 (50)	8 (67)
Vomiting	0	0	1 (33)	0	0	1 (33)	1 (25)	3 (60)	2 (33)	6 (50)
Anorexia	0	0	0	0	0	0	0	0	2 (33)	3 (25)
Abdominal pain	0	0	0	0	1 (33)	0	1 (25)	1 (20)	0	1 (8)
Constipation	1 (33)	0	1 (33)	0	0	0	0	1 (20)	0	1 (8)
Dyspepsia	0	0	0	1 (33)	0	0	1 (25)	0	1 (17)	1 (8)
Skin odor abnormal	0	0	0	0	0	0	0	0	0	4 (33)

Adverse event (preferred term)	Dose level, mg, n (%)
	N = 3						N = 4	N = 5	N = 6	N = 12
	200	400	1000	1400	2000	2400	3000	4000	5000	6000
Hematologic
Neutropenia	0	0	0	0	0	0	1 (25)	1 (20)	0	1 (8)
Nonhematologic
Nausea	1 (33)	0	0	3 (100)	2 (67)	2 (67)	2 (50)	3 (60)	5 (83)	11 (92)
Diarrhea	0	0	1 (33)	1 (33)	1 (33)	0	2 (50)	3 (60)	3 (50)	8 (67)
Vomiting	0	0	1 (33)	0	0	1 (33)	1 (25)	3 (60)	2 (33)	6 (50)
Anorexia	0	0	0	0	0	0	0	0	2 (33)	3 (25)
Abdominal pain	0	0	0	0	1 (33)	0	1 (25)	1 (20)	0	1 (8)
Constipation	1 (33)	0	1 (33)	0	0	0	0	1 (20)	0	1 (8)
Dyspepsia	0	0	0	1 (33)	0	0	1 (25)	0	1 (17)	1 (8)
Skin odor abnormal	0	0	0	0	0	0	0	0	0	4 (33)