Hematologic and nonhematologic adverse events related to ezatiostat tablets in 5% or more of patients: by grade
| Adverse event (preferred term) . | For all dose groups combined: maximum toxicity grade (N = 45), n (%) . | ||||
|---|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . | |
| Hematologic | |||||
| Neutropenia | 0 | 0 | 0 | 3 (7) | 0 |
| Nonhematologic | |||||
| Nausea | 25 (56) | 4 (9) | 0 | 0 | 0 |
| Diarrhea | 16 (36) | 3 (7) | 0 | 0 | 0 |
| Vomiting | 11 (24) | 3 (7) | 0 | 0 | 0 |
| Anorexia | 3 (7) | 2 (4) | 0 | 0 | 0 |
| Abdominal pain | 4 (9) | 0 | 0 | 0 | 0 |
| Constipation | 4 (9) | 0 | 0 | 0 | 0 |
| Dyspepsia | 3 (7) | 1 (2) | 0 | 0 | 0 |
| Skin odor abnormal | 3 (7) | 1 (2) | 0 | 0 | 0 |
| Adverse event (preferred term) . | For all dose groups combined: maximum toxicity grade (N = 45), n (%) . | ||||
|---|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . | |
| Hematologic | |||||
| Neutropenia | 0 | 0 | 0 | 3 (7) | 0 |
| Nonhematologic | |||||
| Nausea | 25 (56) | 4 (9) | 0 | 0 | 0 |
| Diarrhea | 16 (36) | 3 (7) | 0 | 0 | 0 |
| Vomiting | 11 (24) | 3 (7) | 0 | 0 | 0 |
| Anorexia | 3 (7) | 2 (4) | 0 | 0 | 0 |
| Abdominal pain | 4 (9) | 0 | 0 | 0 | 0 |
| Constipation | 4 (9) | 0 | 0 | 0 | 0 |
| Dyspepsia | 3 (7) | 1 (2) | 0 | 0 | 0 |
| Skin odor abnormal | 3 (7) | 1 (2) | 0 | 0 | 0 |