Table 1 ICAM-2, JAM-A, and PECAM-1... | American Society of Hematology

Table 1

ICAM-2, JAM-A, and PECAM-1 mediate leukocyte transmigration in vivo in C57BL/6 mice in a stimulus-dependent manner

Junctional protein	Dependent	Independent
ICAM-2	IL-1β,¹⁴ ischemia/reperfusion injury*	TNF-α,¹⁴ thioglycollate,¹⁴ LTB₄*
JAM-A	IL-1β,⁸ ischemia/reperfusion injury⁸	LTB₄,⁸ PAF⁸
PECAM-1	IL-1β¹⁵	TNF-α,¹⁵ thioglycollate²²

Junctional protein	Dependent	Independent
ICAM-2	IL-1β,¹⁴ ischemia/reperfusion injury*	TNF-α,¹⁴ thioglycollate,¹⁴ LTB₄*
JAM-A	IL-1β,⁸ ischemia/reperfusion injury⁸	LTB₄,⁸ PAF⁸
PECAM-1	IL-1β¹⁵	TNF-α,¹⁵ thioglycollate²²

The table summarizes previous data from our group showing that the ability of the endothelial cell junctional molecules ICAM-2, JAM-A, and PECAM-1 to mediate leukocyte transmigration is dependent on the nature of the stimulus. All these studies were conducted in C57BL/6 mice.

Unpublished data.

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