Adverse events associated with dasatinib (all treated patients)
| . | 140 mg once daily (N = 157) . | 70 mg twice daily (N = 159) . | ||
|---|---|---|---|---|
| All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | |
| Nonhematologic adverse events,* n (%) | ||||
| Diarrhea | 49 (31) | 4 (3) | 50 (31) | 5 (3) |
| Fluid retention | 53 (34) | 12 (8) | 77 (48) | 17 (11) |
| Pleural effusion† | 31 (20) | 11 (7) | 62 (39) | 10 (6) |
| Superficial edema | 28 (18) | 1 (1) | 32 (20) | 0 |
| Other fluid retention | 7 (4) | 2 (1) | 24 (15) | 8 (5) |
| Nausea | 30 (19) | 1 (1) | 28 (18) | 3 (2) |
| Headache | 43 (27) | 2 (1) | 37 (23) | 1 (1) |
| Fatigue | 30 (19) | 3 (2) | 32 (20) | 5 (3) |
| Vomiting | 18 (11) | 1 (1) | 24 (15) | 2 (1) |
| Pyrexia | 18 (11) | 3 (2) | 18 (11) | 2 (1) |
| Dyspnea | 32 (20) | 5 (3) | 37 (23) | 11 (7) |
| Hemorrhage | 41 (26) | 13 (8) | 48 (30) | 11 (7) |
| Gastrointestinal bleeding | 13 (8) | 9 (6) | 21 (13) | 10 (6) |
| Other | 30 (19) | 3 (2) | 33 (21) | 2 (1) |
| Cough | 12 (8) | 0 | 18 (11) | 0 |
| Rash | 23 (15) | 0 | 29 (18) | 1 (1) |
| Myalgia | 11 (7) | 1 (1) | 21 (13) | 3 (2) |
| Arthralgia | 15 (10) | 0 | 13 (8) | 2 (1) |
| Musculoskeletal pain | 18 (11) | 0 | 23 (14) | 3 (2) |
| Febrile neutropenia | 6 (4) | 6 (4) | 16 (10) | 16 (10) |
| Infection‡ | 16 (10) | 9 (6) | 17 (11) | 3 (2) |
| Cytopenia | ||||
| Anemia | 154/155 (99) | 74/155 (48) | 158/159 (99) | 68/159 (43) |
| Leukopenia | 127/155 (82) | 69/155 (45) | 136/159 (86) | 65/159 (41) |
| Neutropenia | 130/155 (84) | 91/155 (59) | 141/159 (89) | 109/159 (69) |
| Thrombocytopenia | 137/155 (88) | 99/155 (64) | 148/159 (93) | 107/159 (67) |
| . | 140 mg once daily (N = 157) . | 70 mg twice daily (N = 159) . | ||
|---|---|---|---|---|
| All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | |
| Nonhematologic adverse events,* n (%) | ||||
| Diarrhea | 49 (31) | 4 (3) | 50 (31) | 5 (3) |
| Fluid retention | 53 (34) | 12 (8) | 77 (48) | 17 (11) |
| Pleural effusion† | 31 (20) | 11 (7) | 62 (39) | 10 (6) |
| Superficial edema | 28 (18) | 1 (1) | 32 (20) | 0 |
| Other fluid retention | 7 (4) | 2 (1) | 24 (15) | 8 (5) |
| Nausea | 30 (19) | 1 (1) | 28 (18) | 3 (2) |
| Headache | 43 (27) | 2 (1) | 37 (23) | 1 (1) |
| Fatigue | 30 (19) | 3 (2) | 32 (20) | 5 (3) |
| Vomiting | 18 (11) | 1 (1) | 24 (15) | 2 (1) |
| Pyrexia | 18 (11) | 3 (2) | 18 (11) | 2 (1) |
| Dyspnea | 32 (20) | 5 (3) | 37 (23) | 11 (7) |
| Hemorrhage | 41 (26) | 13 (8) | 48 (30) | 11 (7) |
| Gastrointestinal bleeding | 13 (8) | 9 (6) | 21 (13) | 10 (6) |
| Other | 30 (19) | 3 (2) | 33 (21) | 2 (1) |
| Cough | 12 (8) | 0 | 18 (11) | 0 |
| Rash | 23 (15) | 0 | 29 (18) | 1 (1) |
| Myalgia | 11 (7) | 1 (1) | 21 (13) | 3 (2) |
| Arthralgia | 15 (10) | 0 | 13 (8) | 2 (1) |
| Musculoskeletal pain | 18 (11) | 0 | 23 (14) | 3 (2) |
| Febrile neutropenia | 6 (4) | 6 (4) | 16 (10) | 16 (10) |
| Infection‡ | 16 (10) | 9 (6) | 17 (11) | 3 (2) |
| Cytopenia | ||||
| Anemia | 154/155 (99) | 74/155 (48) | 158/159 (99) | 68/159 (43) |
| Leukopenia | 127/155 (82) | 69/155 (45) | 136/159 (86) | 65/159 (41) |
| Neutropenia | 130/155 (84) | 91/155 (59) | 141/159 (89) | 109/159 (69) |
| Thrombocytopenia | 137/155 (88) | 99/155 (64) | 148/159 (93) | 107/159 (67) |