Summary of m/z species of highest significance in sickle cell patients with pulmonary hypertension
| m/z by SELDI-TOF MS, Da . | Multivariate analysis of significance . | Identity . | Identification method . | Level in PAH . | P . |
|---|---|---|---|---|---|
| 28 101 | RF, SLR | Apolipoprotein A-I | LC-MS/MS MALDI-TOF | Low | .001 |
| 8900 | SLR | Apolipoprotein A-II | LC-MS/MS | High | .03 |
| 13 455 | RF | Serum amyloid A-4 | LC-MS/MS | High | .001 |
| 89 443 | RF | Plasminogen | LC-MS/MS | Low | .004 |
| 75 188 | RF | Haptoglobin dimer | LC-MS/MS MALDI-TOF | Low | .004 |
| 18 475 | RF | Galectin-1 (tentative) | Literature search | Low | .001 |
| m/z by SELDI-TOF MS, Da . | Multivariate analysis of significance . | Identity . | Identification method . | Level in PAH . | P . |
|---|---|---|---|---|---|
| 28 101 | RF, SLR | Apolipoprotein A-I | LC-MS/MS MALDI-TOF | Low | .001 |
| 8900 | SLR | Apolipoprotein A-II | LC-MS/MS | High | .03 |
| 13 455 | RF | Serum amyloid A-4 | LC-MS/MS | High | .001 |
| 89 443 | RF | Plasminogen | LC-MS/MS | Low | .004 |
| 75 188 | RF | Haptoglobin dimer | LC-MS/MS MALDI-TOF | Low | .004 |
| 18 475 | RF | Galectin-1 (tentative) | Literature search | Low | .001 |
m/z indicates mass-to-charge ratio; SELDI-TOF MS, surface-enhanced laser desorption/ionization–time-of-flight mass spectrometry; Da, Daltons; RF, Random Forest; SLR, stepwise logistical regression; LC-MS/MS, liquid chromatography tandem mass spectrometry; MALDI-TOF, matrix assisted laser desorption-ionization time-of-flight mass spectrometry; and P, significance by 2-tailed unpaired t test.