Immunologic abnormalities during follow-up
| . | 1 y after HSCT, n (%) . | 2 y after HSCT, n (%) . | Last follow-up, n (%) . | |
|---|---|---|---|---|
| 5-15 y . | > 15 y . | |||
| Low CD3+* | 19/79 (24) | 20/83 (24) | 8/35 (23) | 4/32 (12.5) |
| Low CD4+† | 25/79 (31.6) | 22/83 (26) | 8/35 (23) | 4/32 (12.5) |
| Low CD8+‡ | 17/79 (21.5) | 17/83 (20) | 3/35 (9) | 1/32 (3) |
| Low naive CD4+ (< 200/μL) | ND | ND | 11/25 (44) | 17/30 (56) |
| Low NK cell (< 50/μL) | ND | ND | 10/30 (33) | 9/31 (29) |
| Low T-cell function§ | 9/79 (11) | 7/83 (8.5) | 5/35 (14) | 2/32 (6) |
| Immunoglobulin substitution | 46/90 (51.1) | 35/90 (39) | 13/40 (32.5) | 4/38 (12.5) |
| . | 1 y after HSCT, n (%) . | 2 y after HSCT, n (%) . | Last follow-up, n (%) . | |
|---|---|---|---|---|
| 5-15 y . | > 15 y . | |||
| Low CD3+* | 19/79 (24) | 20/83 (24) | 8/35 (23) | 4/32 (12.5) |
| Low CD4+† | 25/79 (31.6) | 22/83 (26) | 8/35 (23) | 4/32 (12.5) |
| Low CD8+‡ | 17/79 (21.5) | 17/83 (20) | 3/35 (9) | 1/32 (3) |
| Low naive CD4+ (< 200/μL) | ND | ND | 11/25 (44) | 17/30 (56) |
| Low NK cell (< 50/μL) | ND | ND | 10/30 (33) | 9/31 (29) |
| Low T-cell function§ | 9/79 (11) | 7/83 (8.5) | 5/35 (14) | 2/32 (6) |
| Immunoglobulin substitution | 46/90 (51.1) | 35/90 (39) | 13/40 (32.5) | 4/38 (12.5) |
ND indicates not done.
Low CD3+ T-cell counts: 1 year, < 1000 lymphocytes/μL; 2 years, < 1400/μL; 5-15 years, < 1000/μL; > 15 years, < 800/μL.
Low CD4+ T-cell counts: 1 year, < 500/μL; 2 years, < 650/μL; 5-15 years, < 450/μL; > 15 years, < 300/μL.
Low CD8+ T-cell counts: 1 year, < 300/μL; 2 years, < 400/μL; 5-15 years, < 300/μL; > 15 years, < 200/μL.
Proliferative response to mitogens: < 30 000 cpm and/or response to antigen: < 10 000 cpm.