Risk of invasive solid cancers according to age at transplantation, conditioning with radiation (TBI or LFI), and time since HCT
| Age at HCT, y . | No conditioning radiation . | Conditioning radiation . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of pts . | O . | E . | O/E . | 95% CI . | EAR* . | No. of pts . | O . | E . | O/E . | 95% CI . | EAR* . | |
| ≥ 1-y survivors | ||||||||||||
| < 10 | 1092 | 1 | 0.39 | 2.59 | 0.06-14.29 | 1.22 | 1 401 | 30 | 0.54 | 55.29‡ | 37.5-79.31 | 43.2 |
| 10-19 | 1092 | 4 | 0.98 | 4.10‡ | 1.11-10.45 | 5.86 | 2 167 | 13 | 2.09 | 6.23‡ | 3.31-10.64 | 9.70 |
| 20-29 | 1048 | 2 | 2.10 | 0.95 | 0.12-3.44 | −0.24 | 2 539 | 30 | 6.23 | 4.81‡ | 3.25-6.87 | 19.05 |
| 30-39 | 939 | 5 | 3.99 | 1.25 | 0.41-2.92 | 3.25 | 2 399 | 20 | 13.70 | 1.46 | 0.89-2.25 | 6.09 |
| 40-49 | 681 | 4 | 5.22 | 0.77 | 0.21-1.96 | −6.94 | 1 335 | 18 | 15.80 | 1.14 | 0.68-1.80 | 4.45 |
| ≥ 50 | 189 | 4 | 3.20 | 1.25 | 0.34-3.20 | 17.79 | 224 | 3 | 4.18 | 0.72 | 0.15-2.10 | −20.36 |
| All ages | 5041 | 20 | 15.88 | 1.26 | 0.77-1.95 | 2.10 | 10 065 | 114 | 42.53 | 2.68‡ | 2.21-3.22 | 15.39 |
| P trend† | .11 | .79 | < .001 | < .001 | ||||||||
| ≥ 5-y survivors | ||||||||||||
| < 10 | 524 | 1 | 0.17 | 5.73 | 0.15-32.77 | 4.42 | 676 | 23 | 0.29 | 80.28‡ | 50.3-119 | 76.40 |
| 10-19 | 482 | 3 | 0.63 | 4.75 | 0.98-13.92 | 10.91 | 1 114 | 11 | 1.33 | 8.25‡ | 4.13-14.8 | 18.81 |
| 20-29 | 405 | 1 | 1.13 | 0.88 | 0.02-4.93 | −0.87 | 1 260 | 18 | 3.63 | 4.96‡ | 2.94-7.84 | 26.86 |
| 30-39 | 291 | 2 | 1.57 | 1.27 | 0.15-4.60 | 5.29 | 1 079 | 13 | 6.99 | 1.86 | 0.99-3.18 | 15.53 |
| 40-49 | 171 | 0 | 1.08 | 0 | 0-3.42 | −40.14 | 528 | 8 | 6.51 | 1.23 | 0.53-2.42 | 9.63 |
| ≥ 50 | 41 | 1 | 0.56 | 1.8 | 0.05-9.95 | 75.38 | 52 | 1 | 1.19 | 0.84 | 0.02-4.68 | −16.29 |
| All ages | 1914 | 8 | 5.15 | 1.55 | 0.67-3.06 | 4.26 | 4 709 | 74 | 19.9 | 3.71‡ | 2.91-4.66 | 28.46 |
| P trend† | .06 | .53 | < .001 | < .001 | ||||||||
| Age at HCT, y . | No conditioning radiation . | Conditioning radiation . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of pts . | O . | E . | O/E . | 95% CI . | EAR* . | No. of pts . | O . | E . | O/E . | 95% CI . | EAR* . | |
| ≥ 1-y survivors | ||||||||||||
| < 10 | 1092 | 1 | 0.39 | 2.59 | 0.06-14.29 | 1.22 | 1 401 | 30 | 0.54 | 55.29‡ | 37.5-79.31 | 43.2 |
| 10-19 | 1092 | 4 | 0.98 | 4.10‡ | 1.11-10.45 | 5.86 | 2 167 | 13 | 2.09 | 6.23‡ | 3.31-10.64 | 9.70 |
| 20-29 | 1048 | 2 | 2.10 | 0.95 | 0.12-3.44 | −0.24 | 2 539 | 30 | 6.23 | 4.81‡ | 3.25-6.87 | 19.05 |
| 30-39 | 939 | 5 | 3.99 | 1.25 | 0.41-2.92 | 3.25 | 2 399 | 20 | 13.70 | 1.46 | 0.89-2.25 | 6.09 |
| 40-49 | 681 | 4 | 5.22 | 0.77 | 0.21-1.96 | −6.94 | 1 335 | 18 | 15.80 | 1.14 | 0.68-1.80 | 4.45 |
| ≥ 50 | 189 | 4 | 3.20 | 1.25 | 0.34-3.20 | 17.79 | 224 | 3 | 4.18 | 0.72 | 0.15-2.10 | −20.36 |
| All ages | 5041 | 20 | 15.88 | 1.26 | 0.77-1.95 | 2.10 | 10 065 | 114 | 42.53 | 2.68‡ | 2.21-3.22 | 15.39 |
| P trend† | .11 | .79 | < .001 | < .001 | ||||||||
| ≥ 5-y survivors | ||||||||||||
| < 10 | 524 | 1 | 0.17 | 5.73 | 0.15-32.77 | 4.42 | 676 | 23 | 0.29 | 80.28‡ | 50.3-119 | 76.40 |
| 10-19 | 482 | 3 | 0.63 | 4.75 | 0.98-13.92 | 10.91 | 1 114 | 11 | 1.33 | 8.25‡ | 4.13-14.8 | 18.81 |
| 20-29 | 405 | 1 | 1.13 | 0.88 | 0.02-4.93 | −0.87 | 1 260 | 18 | 3.63 | 4.96‡ | 2.94-7.84 | 26.86 |
| 30-39 | 291 | 2 | 1.57 | 1.27 | 0.15-4.60 | 5.29 | 1 079 | 13 | 6.99 | 1.86 | 0.99-3.18 | 15.53 |
| 40-49 | 171 | 0 | 1.08 | 0 | 0-3.42 | −40.14 | 528 | 8 | 6.51 | 1.23 | 0.53-2.42 | 9.63 |
| ≥ 50 | 41 | 1 | 0.56 | 1.8 | 0.05-9.95 | 75.38 | 52 | 1 | 1.19 | 0.84 | 0.02-4.68 | −16.29 |
| All ages | 1914 | 8 | 5.15 | 1.55 | 0.67-3.06 | 4.26 | 4 709 | 74 | 19.9 | 3.71‡ | 2.91-4.66 | 28.46 |
| P trend† | .06 | .53 | < .001 | < .001 | ||||||||
pts indicates patients.
EAR was calculated as [(O-E)/PYR] × 10 000. (Analyses excluded patients with unknown radiation).
P for trend of increasing risk with increasing age at transplantation. P for test of difference in age trends for radiation versus no radiation, adjusted for primary disease, registry, and time since transplantation: P < .001 for 1+ year survivors, and P = .09 for 5+ year survivors.
P < .05.