Clinical and genetic characteristics of CLL patients in the cohort stratified by TP53 mutation
| Characteristic/category . | All . | WT TP53 . | Mutation TP53 . | Significance, P . |
|---|---|---|---|---|
| Stage (at diagnosis) | ||||
| Mean age, y | 61.5 | 64.4 | 61.1 | |
| Male, % | 60 | 58 | 67 | |
| Female, % | 40 | 42 | 33 | NS |
| Binet A, % | 56 | 57 | 44 | |
| Binet B, % | 25 | 23 | 39 | |
| Binet C, % | 11 | 12 | 6 | |
| NA, % | 8 | 7 | 11 | NS |
| Stage (at study) | ||||
| Binet A, % | 47 | 53 | 17 | |
| Binet B, % | 29 | 27 | 44 | |
| Binet C, % | 22 | 19 | 39 | |
| NA, % | 2 | 2 | 0 | .015 |
| Chemotherapy prior to mutation analysis | ||||
| None, % | 78 | 83 | 44 | |
| ≥ 1, % | 21 | 16 | 56 | |
| NA, % | 1 | 1 | 0 | < .001 |
| FISH | ||||
| Normal, % | 16 | 18 | 6 | |
| 13q- single, % | 29 | 31 | 11 | |
| 11q-, % | 19 | 20 | 11 | .09 |
| 12q+, % | 16 | 19 | 0 | .07 |
| 17p-, % | 13 | 3 | 72 | < .001 |
| Other, % | 8 | 9 | 0 | |
| VH status | ||||
| Mutated, % | 32 | 35 | 11 | |
| Unmutated, % | 59 | 55 | 83 | |
| NA, % | 10 | 10 | 6 | .03 |
| Total, % | 100 (n = 126) | 100 (n = 108) | 100 (n = 18) |
| Characteristic/category . | All . | WT TP53 . | Mutation TP53 . | Significance, P . |
|---|---|---|---|---|
| Stage (at diagnosis) | ||||
| Mean age, y | 61.5 | 64.4 | 61.1 | |
| Male, % | 60 | 58 | 67 | |
| Female, % | 40 | 42 | 33 | NS |
| Binet A, % | 56 | 57 | 44 | |
| Binet B, % | 25 | 23 | 39 | |
| Binet C, % | 11 | 12 | 6 | |
| NA, % | 8 | 7 | 11 | NS |
| Stage (at study) | ||||
| Binet A, % | 47 | 53 | 17 | |
| Binet B, % | 29 | 27 | 44 | |
| Binet C, % | 22 | 19 | 39 | |
| NA, % | 2 | 2 | 0 | .015 |
| Chemotherapy prior to mutation analysis | ||||
| None, % | 78 | 83 | 44 | |
| ≥ 1, % | 21 | 16 | 56 | |
| NA, % | 1 | 1 | 0 | < .001 |
| FISH | ||||
| Normal, % | 16 | 18 | 6 | |
| 13q- single, % | 29 | 31 | 11 | |
| 11q-, % | 19 | 20 | 11 | .09 |
| 12q+, % | 16 | 19 | 0 | .07 |
| 17p-, % | 13 | 3 | 72 | < .001 |
| Other, % | 8 | 9 | 0 | |
| VH status | ||||
| Mutated, % | 32 | 35 | 11 | |
| Unmutated, % | 59 | 55 | 83 | |
| NA, % | 10 | 10 | 6 | .03 |
| Total, % | 100 (n = 126) | 100 (n = 108) | 100 (n = 18) |
NA indicates not applicable; and NS, not significant.