Guidelines for selecting ABO blood group for erythrocyte- and plasma-containing components for patients undergoing HPC transplantation with ablative conditioning*
| Recipient RBC group . | Donor's RBC group . | Category of ABO mismatch† . | Erythrocyte transfusion . | Platelet or plasma transfusion . |
|---|---|---|---|---|
| A | O | Minor | O | A, AB |
| B | O | Minor | O | B, AB |
| AB | O | Minor | O | AB |
| AB | A | Minor | A, O | AB |
| AB | B | Minor | B, O | AB |
| O | A | Major | O | A, AB |
| O | B | Major | O | B, AB |
| O | AB | Major | O | AB |
| A | AB | Major | A, O | AB |
| B | AB | Major | B, O | AB |
| A | B | Minor and major | O | AB |
| B | A | Minor and major | O | AB |
| A | A | None | A, O | A, AB |
| B | B | None | B, O | B, AB |
| AB | AB | None | AB, A, B, O | AB |
| O | O | None | O | O, A, B, AB |
| Recipient RBC group . | Donor's RBC group . | Category of ABO mismatch† . | Erythrocyte transfusion . | Platelet or plasma transfusion . |
|---|---|---|---|---|
| A | O | Minor | O | A, AB |
| B | O | Minor | O | B, AB |
| AB | O | Minor | O | AB |
| AB | A | Minor | A, O | AB |
| AB | B | Minor | B, O | AB |
| O | A | Major | O | A, AB |
| O | B | Major | O | B, AB |
| O | AB | Major | O | AB |
| A | AB | Major | A, O | AB |
| B | AB | Major | B, O | AB |
| A | B | Minor and major | O | AB |
| B | A | Minor and major | O | AB |
| A | A | None | A, O | A, AB |
| B | B | None | B, O | B, AB |
| AB | AB | None | AB, A, B, O | AB |
| O | O | None | O | O, A, B, AB |
RBC indicates red blood cell; HPC, hematopoietic progenitor cell.
These guidelines apply from time of initiation of myeloablative therapy until reverse and forward erythrocyte typing of the donor.
Major (“forward”) mismatch occurs when donor's RBC-ABO group is serologically incompatible with recipient's plasma. Minor (“reverse”) mismatch occurs when recipient's RBC-ABO type is serologically incompatible with donor's plasma.