Activating Notch1 mutations in oncogenic K-Ras–initiated T-cell malignancies
| Sample no. . | DNA* . | Protein† . | Consequence . |
|---|---|---|---|
| 9934 | 7216_7217insC | Frameshift starting at AA 2380 | Premature stop in PEST domain |
| 9927 | wt | NA | NA |
| 9980 | 7161delinsCC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| 9976 | wt | NA | NA |
| 9972 | wt | NA | NA |
| 9851 | 7161_7162insCTCGCTC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| 9852 | wt | NA | NA |
| AT680 | 7384_7385insA | Frameshift starting at AA 2435 | Premature stop in PEST domain |
| 11211 | wt | NA | NA |
| 9891 | 7161delinsCCGCC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| AT693 | wt | NA | NA |
| 9928 | 7236_7237insT | Frameshift starting at AA 2387 | Premature stop in PEST domain |
| 9926 | wt | NA | NA |
| 9855 | wt | NA | NA |
| 9988 | 7161delinsCC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| AT690 | 7274_7275insGG | Frameshift starting at AA 2399 | Premature stop in PEST domain |
| Sample no. . | DNA* . | Protein† . | Consequence . |
|---|---|---|---|
| 9934 | 7216_7217insC | Frameshift starting at AA 2380 | Premature stop in PEST domain |
| 9927 | wt | NA | NA |
| 9980 | 7161delinsCC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| 9976 | wt | NA | NA |
| 9972 | wt | NA | NA |
| 9851 | 7161_7162insCTCGCTC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| 9852 | wt | NA | NA |
| AT680 | 7384_7385insA | Frameshift starting at AA 2435 | Premature stop in PEST domain |
| 11211 | wt | NA | NA |
| 9891 | 7161delinsCCGCC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| AT693 | wt | NA | NA |
| 9928 | 7236_7237insT | Frameshift starting at AA 2387 | Premature stop in PEST domain |
| 9926 | wt | NA | NA |
| 9855 | wt | NA | NA |
| 9988 | 7161delinsCC | Frameshift starting at AA 2361 | Premature stop in PEST domain |
| AT690 | 7274_7275insGG | Frameshift starting at AA 2399 | Premature stop in PEST domain |
AA indicates amino acid; and NA, not applicable.
Numbers indicate amino acid residues in Notch1 at which mutation occurs.