Differences in the clinical features of nasal and extranasal NK/T-cell lymphoma
| Clinical features . | Nasal . | Extranasal . | P (nasal vs extranasal) . | Aggressive/unclassifiable . |
|---|---|---|---|---|
| Number of cases | 92 | 35 | 9 | |
| Median age, y (range) | 52 (21-89) | 45 (19-86) | .67 | 32 (21-71) |
| Male, % | 64 | 66 | 1.0 | 78 |
| Stage III/IV, % | 27 | 68 | < .001 | 57 |
| B symptoms, % | 39 | 54 | .161 | 78 |
| Nonambulatory, % | 9 | 37 | < .001 | 56 |
| Mass > 5 cm, % | 12 | 68 | .026 | 22 |
| Extranodal sites > 2, % | 16 | 55 | < .001 | 47 |
| Bone marrow +, % | 10 | 14 | .53 | 89 |
| Hb < 11 g/dL, % | 25 | 42 | .11 | 63 |
| Platelets < 150 × 109/L, % | 12 | 25 | .09 | 70 |
| CRP > normal, % | 51 | 38 | .31 | 37 |
| LDH > normal, % | 45 | 60 | .009 | 57 |
| Hemophagocytosis, % | 3 | 3 | 1.0 | 11 |
| Clinical features . | Nasal . | Extranasal . | P (nasal vs extranasal) . | Aggressive/unclassifiable . |
|---|---|---|---|---|
| Number of cases | 92 | 35 | 9 | |
| Median age, y (range) | 52 (21-89) | 45 (19-86) | .67 | 32 (21-71) |
| Male, % | 64 | 66 | 1.0 | 78 |
| Stage III/IV, % | 27 | 68 | < .001 | 57 |
| B symptoms, % | 39 | 54 | .161 | 78 |
| Nonambulatory, % | 9 | 37 | < .001 | 56 |
| Mass > 5 cm, % | 12 | 68 | .026 | 22 |
| Extranodal sites > 2, % | 16 | 55 | < .001 | 47 |
| Bone marrow +, % | 10 | 14 | .53 | 89 |
| Hb < 11 g/dL, % | 25 | 42 | .11 | 63 |
| Platelets < 150 × 109/L, % | 12 | 25 | .09 | 70 |
| CRP > normal, % | 51 | 38 | .31 | 37 |
| LDH > normal, % | 45 | 60 | .009 | 57 |
| Hemophagocytosis, % | 3 | 3 | 1.0 | 11 |
Hb indicates hemoglobin; LDH, lactate dehydrogenase; and CRP, C-reactive protein.