Multivariable analysis of the relative risk of total thrombosis among 1063 ET patients
| Models . | Platelet count* (×109/L) . | White blood cell count* (×109/L) . | ||
|---|---|---|---|---|
| 650 to 1000 . | More than 1000 . | 8.0 to 11.0 . | More than 11.0 . | |
| 1. Unadjusted | 0.7 (0.4-1.1) .2 | 0.5 (0.3-0.9) .03 | 1.3 (0.8-1.9) .3 | 1.7 (1.0-2.7) .04 |
| 2. Variables adjusted | 0.6 (0.4-1.0) .1 | 0.5 (0.3-0.8) .01 | 1.4 (0.9-2.1) .2 | 1.8 (1.1-2.9) .02 |
| 3. JAK2V617F adjusted | 0.6 (0.4-1.1) .1 | 0.6 (0.3-1.1) .10 | 1.5 (0.9-2.5) .1 | 2.0 (1.1-3.6) .02 |
| Models . | Platelet count* (×109/L) . | White blood cell count* (×109/L) . | ||
|---|---|---|---|---|
| 650 to 1000 . | More than 1000 . | 8.0 to 11.0 . | More than 11.0 . | |
| 1. Unadjusted | 0.7 (0.4-1.1) .2 | 0.5 (0.3-0.9) .03 | 1.3 (0.8-1.9) .3 | 1.7 (1.0-2.7) .04 |
| 2. Variables adjusted | 0.6 (0.4-1.0) .1 | 0.5 (0.3-0.8) .01 | 1.4 (0.9-2.1) .2 | 1.8 (1.1-2.9) .02 |
| 3. JAK2V617F adjusted | 0.6 (0.4-1.1) .1 | 0.6 (0.3-1.1) .10 | 1.5 (0.9-2.5) .1 | 2.0 (1.1-3.6) .02 |
Data are HR (95% CI) P value.
Reference categories: platelet count less than 650 ×109/L; white blood cell count less than 8 ×109/L.
Model 1: platelet count (3 categories) or white blood cell count (3 categories).
Model 2: model 1 plus center (3 categories), sex (2 categories), standard risk factors: age 60 years or older and/or previous thrombotic event (yes/no), hemoglobin at diagnosis (2 categories, median value used as cutoff), white blood cell count or platelet at diagnosis, respectively (2 categories, median value used as cutoff), antiplatelets use (yes/no), chemotherapy use (yes/no).
Model 3: model 2 plus JAK2V617F status (yes/no).