Aberrancies per subpopulation in the MDS WHO subgroups RA with or without RS and MDS-U as detected by flow cytometry
| UPN . | Diagnosis* . | Flow cytometry† . | Aberrancies in blasts . | Aberrancies in granulocytes . | Aberrancies in monocytes . |
|---|---|---|---|---|---|
| 1 | RA | - g M | (L) | Pattern CD11b/CD13 | CD13 heterogeneous, CD14, CD36, HLA-DR low |
| 2 | RA | b - - | CD7+ (L) | — | — |
| 3 | RA | b g M | CD7+ | Pattern CD11b/CD13 | CD7+, low number, CD11b and CD36 low |
| 4 | RA | - G m | (L) | Hypogranularity, pattern CD11b/CD13 | Low number, HLA-DR low |
| 5 | RA | b - m | CD7+(L) | — | Low number |
| 6 | RA | - g M | — | CD13 low, shift to the left | CD13 heterogeneous, CD11b and HLA-DR low |
| 7 | RA | - g m | — | CD16 low | Low number |
| 8 | RA | - g - | — | HLA-DR+ | — |
| 9 | RARS | b g M | CD7+ (L) | Pattern CD11b/CD13 | CD36 overexpression, HLA-DR low |
| 10 | RARS | - g m | — | CD13 low, CD16− | CD13 heterogeneous |
| 11 | RARS | - G M | (L) | hypogranularity, CD13 low, pattern CD11b/CD13 | CD13 heterogeneous, CD36 and HLA-DR low |
| 12 | RARS | - g m | (L) | CD13 low | High number, CD11b overexpression |
| 13 | RARS | - G M | (L) | Low number, pattern CD11b/CD13/CD16, CD11b overexpression, HLA-DR+ | Low number, CD13 heterogeneous, CD14 low |
| 47 | MDS-U | bGM | CD5+ CD56+ (L) | CD56+, pattern CD11b/CD13/CD16, CD15 and CD16 weak | CD56+, low number, CD36 and HLA-DR overexpression |
| 48 | MDS-U | - - - | — | — | — |
| UPN . | Diagnosis* . | Flow cytometry† . | Aberrancies in blasts . | Aberrancies in granulocytes . | Aberrancies in monocytes . |
|---|---|---|---|---|---|
| 1 | RA | - g M | (L) | Pattern CD11b/CD13 | CD13 heterogeneous, CD14, CD36, HLA-DR low |
| 2 | RA | b - - | CD7+ (L) | — | — |
| 3 | RA | b g M | CD7+ | Pattern CD11b/CD13 | CD7+, low number, CD11b and CD36 low |
| 4 | RA | - G m | (L) | Hypogranularity, pattern CD11b/CD13 | Low number, HLA-DR low |
| 5 | RA | b - m | CD7+(L) | — | Low number |
| 6 | RA | - g M | — | CD13 low, shift to the left | CD13 heterogeneous, CD11b and HLA-DR low |
| 7 | RA | - g m | — | CD16 low | Low number |
| 8 | RA | - g - | — | HLA-DR+ | — |
| 9 | RARS | b g M | CD7+ (L) | Pattern CD11b/CD13 | CD36 overexpression, HLA-DR low |
| 10 | RARS | - g m | — | CD13 low, CD16− | CD13 heterogeneous |
| 11 | RARS | - G M | (L) | hypogranularity, CD13 low, pattern CD11b/CD13 | CD13 heterogeneous, CD36 and HLA-DR low |
| 12 | RARS | - g m | (L) | CD13 low | High number, CD11b overexpression |
| 13 | RARS | - G M | (L) | Low number, pattern CD11b/CD13/CD16, CD11b overexpression, HLA-DR+ | Low number, CD13 heterogeneous, CD14 low |
| 47 | MDS-U | bGM | CD5+ CD56+ (L) | CD56+, pattern CD11b/CD13/CD16, CD15 and CD16 weak | CD56+, low number, CD36 and HLA-DR overexpression |
| 48 | MDS-U | - - - | — | — | — |
— indicates no aberrancies detected.
Morphologic diagnosis at presentation according to the WHO classification.
Results of flow cytometric analysis: a single aberrancy is depicted in lowercase representing a defined subpopulation: b for blasts, g for granulocytes, and m for monocytes; multiple aberrancies are depicted in uppercase (B, G and M); expression of lineage infidelity markers or CD34 (except for blasts) is depicted by underlining (B, G and M); expression of lineage infidelity markers within normal blast percentages is depicted as b; and (L) indicates decreased number of lymphoid (B-cell) progenitors.