Cynomolgus monkey studies
| Study no. (treatment) . | Duration, days . | Dose, mg/kg . | No. monkeys (sex) . | Necropsy, day(s) . | Compartments sampled (FACS) . | Analysis . |
|---|---|---|---|---|---|---|
| 1 (Vehicle) | 29 | 0 | 4 (2M, 2F) | 29 | B, S, BM, LN | † |
| 1 (XmAb5574) | 29 | 3 | 4 (2M, 2F) | 29 | B, S, BM, LN | † |
| 1 (Anti-CD19 IgG1) | 29 | 3 | 4 (2M, 2F) | 29 | B, S, BM, LN | † |
| 2 (Vehicle) | 85 | 0 | 6 (3M, 3F) | 15* and 85 | B, BM, LN | ‡ |
| 2 (XmAb5574) | 85 | 10 | 6 (3M, 3F) | 15* and 85 | B, BM, LN | ‡ |
| Study no. (treatment) . | Duration, days . | Dose, mg/kg . | No. monkeys (sex) . | Necropsy, day(s) . | Compartments sampled (FACS) . | Analysis . |
|---|---|---|---|---|---|---|
| 1 (Vehicle) | 29 | 0 | 4 (2M, 2F) | 29 | B, S, BM, LN | † |
| 1 (XmAb5574) | 29 | 3 | 4 (2M, 2F) | 29 | B, S, BM, LN | † |
| 1 (Anti-CD19 IgG1) | 29 | 3 | 4 (2M, 2F) | 29 | B, S, BM, LN | † |
| 2 (Vehicle) | 85 | 0 | 6 (3M, 3F) | 15* and 85 | B, BM, LN | ‡ |
| 2 (XmAb5574) | 85 | 10 | 6 (3M, 3F) | 15* and 85 | B, BM, LN | ‡ |
All treatments were given as single 1-hour intravenous infusions.
B indicates blood; S, spleen; BM, bone marrow; and LN, lymph node.
One male and one female were necropsied on day 15.
Analysis for study 1: CD20+CD3− B cells, CD20−CD3− NK cells, pharmacokinetics, and antidrug antibody.
Analysis for study 2: CD20+CD3− B cells, CD16+CD3− NK cells, pharmacokinetics, antidrug antibody, and immunohistochemistry.