Tests for associations between MDM2 or TP53 genotypes and t-AML stratified by treatment modality
| Genotype* . | University of Chicago, no. (%) . | United Kingdom, no (%) . | Combined analysis: site-adjusted OR (95% CI) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| RT . | CT . | CMT . | Control . | RT . | CT . | CMT . | Control . | RT vs control . | CT vs control . | CMT vs control . | |
| MDM2 SNP309 | |||||||||||
| TT | 4 (40) | 13 (42) | 14 (38) | 958 (42) | 15 (38) | 11 (35) | 9 (47) | 330 (46) | 1.0 | 1.0 | 1.0 |
| TG | 5 (50) | 12 (39) | 17 (46) | 1027 (45) | 18 (46) | 15 (48) | 7 (37) | 303 (42) | 1.27 (0.68-2.36) | 1.13 (0.65-1.98) | 1.03 (0.58-1.83) |
| GG | 1 (10) | 6 (19) | 6 (16) | 286 (13) | 6 (15) | 5 (16) | 3 (16) | 88 (12) | 1.34 (0.56-3.27) | 1.62 (0.79-3.36) | 1.36 (0.62-2.97) |
| P for trend† | .41 | .23 | .52 | ||||||||
| TP53 Arg72Pro | |||||||||||
| Arg/Arg | 4 (36) | 17 (53) | 21 (57) | 1255 (56) | 20 (50) | 22 (69) | 11 (58) | 459 (58) | 1.0 | 1.0 | 1.0 |
| Arg/Pro | 6 (55) | 14 (44) | 15 (41) | 838 (38) | 14 (35) | 9 (28) | 8 (42) | 289 (36) | 1.32 (0.72-2.42) | 0.91 (0.54-1.54) | 1.10 (0.64-1.89) |
| Pro/Pro | 1 (9) | 1 (3) | 1 (3) | 131 (6) | 6 (15) | 1 (3) | 0 (0) | 50 (6) | 2.71 (1.13-6.50) | 0.48 (0.12-2.02) | 0.30 (0.04-2.17) |
| P for trend† | .041 | .38 | .58 | ||||||||
| Genotype* . | University of Chicago, no. (%) . | United Kingdom, no (%) . | Combined analysis: site-adjusted OR (95% CI) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| RT . | CT . | CMT . | Control . | RT . | CT . | CMT . | Control . | RT vs control . | CT vs control . | CMT vs control . | |
| MDM2 SNP309 | |||||||||||
| TT | 4 (40) | 13 (42) | 14 (38) | 958 (42) | 15 (38) | 11 (35) | 9 (47) | 330 (46) | 1.0 | 1.0 | 1.0 |
| TG | 5 (50) | 12 (39) | 17 (46) | 1027 (45) | 18 (46) | 15 (48) | 7 (37) | 303 (42) | 1.27 (0.68-2.36) | 1.13 (0.65-1.98) | 1.03 (0.58-1.83) |
| GG | 1 (10) | 6 (19) | 6 (16) | 286 (13) | 6 (15) | 5 (16) | 3 (16) | 88 (12) | 1.34 (0.56-3.27) | 1.62 (0.79-3.36) | 1.36 (0.62-2.97) |
| P for trend† | .41 | .23 | .52 | ||||||||
| TP53 Arg72Pro | |||||||||||
| Arg/Arg | 4 (36) | 17 (53) | 21 (57) | 1255 (56) | 20 (50) | 22 (69) | 11 (58) | 459 (58) | 1.0 | 1.0 | 1.0 |
| Arg/Pro | 6 (55) | 14 (44) | 15 (41) | 838 (38) | 14 (35) | 9 (28) | 8 (42) | 289 (36) | 1.32 (0.72-2.42) | 0.91 (0.54-1.54) | 1.10 (0.64-1.89) |
| Pro/Pro | 1 (9) | 1 (3) | 1 (3) | 131 (6) | 6 (15) | 1 (3) | 0 (0) | 50 (6) | 2.71 (1.13-6.50) | 0.48 (0.12-2.02) | 0.30 (0.04-2.17) |
| P for trend† | .041 | .38 | .58 | ||||||||