Tests for associations between t-AML and MDM2 or TP53 genotypes
| Genotype* . | University of Chicago . | United Kingdom . | Combined analysis . | ||||
|---|---|---|---|---|---|---|---|
| No. patients (%) . | No. controls(%) . | OR(95% CI) . | No. patients(%) . | No. controls(%) . | OR(95% CI) . | Site-adjusted OR (95% CI) . | |
| MDM2 SNP309 | |||||||
| TT | 31 (40) | 958 (42) | 1.0 (Ref) | 35 (39) | 330 (46) | 1.0 (Ref) | 1.0 (Ref) |
| TG | 34 (44) | 1027 (45) | 1.02 (0.62-1.68) | 40 (45) | 303 (42) | 1.24 (0.77-2.01) | 1.13 (0.80-1.60) |
| GG | 13 (17) | 286 (13) | 1.40 (0.73-2.72) | 14 (16) | 88 (12) | 1.50 (0.77-2.92) | 1.46 (0.91-2.32) |
| P for trend | .41 | .20 | .13 | ||||
| TP53 Arg72Pro | |||||||
| Arg/Arg | 42 (52) | 1255 (56) | 1.0 (Ref) | 53 (58) | 459 (58) | 1.0 (Ref) | 1.0 (Ref) |
| Arg/Pro | 35 (44) | 838 (38) | 1.25 (0.79-1.97) | 31 (34) | 289 (36) | 0.93 (0.58-1.48) | 1.08 (0.78-1.50) |
| Pro/Pro | 3 (4) | 131 (6) | 0.68 (0.21-2.24) | 7 (8) | 50 (6) | 1.21 (0.52-2.81) | 0.98 (0.50-1.92) |
| P for trend | .80 | .92 | .80 | ||||
| Genotype* . | University of Chicago . | United Kingdom . | Combined analysis . | ||||
|---|---|---|---|---|---|---|---|
| No. patients (%) . | No. controls(%) . | OR(95% CI) . | No. patients(%) . | No. controls(%) . | OR(95% CI) . | Site-adjusted OR (95% CI) . | |
| MDM2 SNP309 | |||||||
| TT | 31 (40) | 958 (42) | 1.0 (Ref) | 35 (39) | 330 (46) | 1.0 (Ref) | 1.0 (Ref) |
| TG | 34 (44) | 1027 (45) | 1.02 (0.62-1.68) | 40 (45) | 303 (42) | 1.24 (0.77-2.01) | 1.13 (0.80-1.60) |
| GG | 13 (17) | 286 (13) | 1.40 (0.73-2.72) | 14 (16) | 88 (12) | 1.50 (0.77-2.92) | 1.46 (0.91-2.32) |
| P for trend | .41 | .20 | .13 | ||||
| TP53 Arg72Pro | |||||||
| Arg/Arg | 42 (52) | 1255 (56) | 1.0 (Ref) | 53 (58) | 459 (58) | 1.0 (Ref) | 1.0 (Ref) |
| Arg/Pro | 35 (44) | 838 (38) | 1.25 (0.79-1.97) | 31 (34) | 289 (36) | 0.93 (0.58-1.48) | 1.08 (0.78-1.50) |
| Pro/Pro | 3 (4) | 131 (6) | 0.68 (0.21-2.24) | 7 (8) | 50 (6) | 1.21 (0.52-2.81) | 0.98 (0.50-1.92) |
| P for trend | .80 | .92 | .80 | ||||
Ref indicates reference.
MDM2 SNP309 and TP53 Arg72Pro genotypes. The TP53 G allele encodes arginine and the C allele encodes proline.