Cytogenetic features in DS-ALL versus non–DS-ALL
| Cytogenetic features . | DS-ALL, %, n=109 . | Non–DS-ALL, %, n=592 . | P . | Cytogenetic features . | DS-ALL, %, n=109 . | Non–DS-ALL, %, n=592 . | P . |
|---|---|---|---|---|---|---|---|
| No. of anomalies | −3 | 2.8 | 4.1 | NS | |||
| 1 | 33 | 37 | +4 | 7.3 | 14 | NS | |
| 2 | 24 | 11 | <.01 | +6 | 8.3 | 16 | NS |
| 3 or more* | 43 | 52 | del(6q) | 2.8 | 5.4 | NS | |
| Ploidy level | −7 | 3.7 | 4.9 | NS | |||
| Hypodiploidy† | 6.4 | 11 | +8 | 3.7 | 8.3 | NS | |
| Pseudodiploidy‡ | 39 | 42 | −9 | 1.8 | 5.1 | NS | |
| Hyperdiploidy, low§ | 39 | 18 | <.001 | del(9p) | 11 | 4.7 | <.05 |
| Hyperdiploidy, high‖ | 11 | 23 | +10 | 9.2 | 13 | NS | |
| Triploidy | 1.8 | 4.6 | del(12p) | 6.4 | 5.4 | NS | |
| Tetraploidy | 2.8 | 0.8 | −13 | 2.8 | 4.2 | NS | |
| Aberrations | +14 | 11 | 15 | NS | |||
| t(1;19)(q23;p13) | 0.9 | 4.4 | NS | del(14q) | 3.7 | 1.7 | NS |
| t(8;14)(q11;q32) | 2.8 | 0.2 | <.01 | −15 | 3.7 | 4.4 | NS |
| t(8;14)(q24;q32) | 0 | 1.4 | NS | −16 | 4.6 | 2.9 | NS |
| t(9;22)(q34;q11) | 1.0 | 4.7 | <.05 | +17 | 12 | 12 | NS |
| t(11q23) | 0.9 | 12 | <.001 | +18 | 8.3 | 14 | NS |
| t(12;21)(p13;q22) | 10 | 25¶ | NA | −20 | 1.8 | 4.6 | NS |
| +X | 38 | 21 | <.001 | +21 | 17 | 27 | <.05 |
| dup(1q) | 3.7 | 4.4 | NS | +22 | 3.7 | 5.1 | NS |
| Cytogenetic features . | DS-ALL, %, n=109 . | Non–DS-ALL, %, n=592 . | P . | Cytogenetic features . | DS-ALL, %, n=109 . | Non–DS-ALL, %, n=592 . | P . |
|---|---|---|---|---|---|---|---|
| No. of anomalies | −3 | 2.8 | 4.1 | NS | |||
| 1 | 33 | 37 | +4 | 7.3 | 14 | NS | |
| 2 | 24 | 11 | <.01 | +6 | 8.3 | 16 | NS |
| 3 or more* | 43 | 52 | del(6q) | 2.8 | 5.4 | NS | |
| Ploidy level | −7 | 3.7 | 4.9 | NS | |||
| Hypodiploidy† | 6.4 | 11 | +8 | 3.7 | 8.3 | NS | |
| Pseudodiploidy‡ | 39 | 42 | −9 | 1.8 | 5.1 | NS | |
| Hyperdiploidy, low§ | 39 | 18 | <.001 | del(9p) | 11 | 4.7 | <.05 |
| Hyperdiploidy, high‖ | 11 | 23 | +10 | 9.2 | 13 | NS | |
| Triploidy | 1.8 | 4.6 | del(12p) | 6.4 | 5.4 | NS | |
| Tetraploidy | 2.8 | 0.8 | −13 | 2.8 | 4.2 | NS | |
| Aberrations | +14 | 11 | 15 | NS | |||
| t(1;19)(q23;p13) | 0.9 | 4.4 | NS | del(14q) | 3.7 | 1.7 | NS |
| t(8;14)(q11;q32) | 2.8 | 0.2 | <.01 | −15 | 3.7 | 4.4 | NS |
| t(8;14)(q24;q32) | 0 | 1.4 | NS | −16 | 4.6 | 2.9 | NS |
| t(9;22)(q34;q11) | 1.0 | 4.7 | <.05 | +17 | 12 | 12 | NS |
| t(11q23) | 0.9 | 12 | <.001 | +18 | 8.3 | 14 | NS |
| t(12;21)(p13;q22) | 10 | 25¶ | NA | −20 | 1.8 | 4.6 | NS |
| +X | 38 | 21 | <.001 | +21 | 17 | 27 | <.05 |
| dup(1q) | 3.7 | 4.4 | NS | +22 | 3.7 | 5.1 | NS |
ALL indicates acute lymphoblastic leukemia; DS, Down syndrome; NS, not significant; and NA, not applicable (all DS-ALLs were not tested for the presence of ETV6/RUNX1).
Includes also cases with “incomplete” karyotypes.
Less than 47 chromosomes in DS-ALL (all these cases had 46 chromosomes).
Forty-seven chromosomes in DS-ALL.
Forty-seven to 50 chromosomes in non–DS-ALL, 48–50 chromosomes in DS-ALL.
Fifty-one to 57 chromosomes.
Based on Forestier et al.49