Association of rs342293 with mean platelet volume in the 5 studies and meta-analysis summary statistics for the blood traits investigated
| . | Subjects, n . | G allele frequency . | Mean ± SD level of MPV, fL . | Per-G allele effect (SE), log (fL)* . | P . | ||
|---|---|---|---|---|---|---|---|
| GG . | GC . | CC . | |||||
| Cohort | |||||||
| UKBS-CC1 | 1221 | 0.46 | 9.62 ± 1.02 | 9.50 ± 1.03 | 9.21 ± 0.88 | 0.022 (0.004) | 2.21 × 10−7 |
| TwinsUK | 1050 | 0.46 | 11.29 ± 1.10 | 11.06 ± 1.06 | 10.94 ± 0.93 | 0.014 (0.004) | 3.08 × 10−4 |
| KORA F3 500K | 1601 | 0.45 | 8.81 ± 1.02 | 8.71 ± 0.91 | 8.56 ± 0.90 | 0.014 (0.004) | 1.6 × 10−4 |
| CBR | 3410 | 0.45 | 9.63 ± 0.93 | 9.02 ± 0.91 | 8.93 ± 0.91 | 0.013 (0.002) | 2.03 × 10−7 |
| UKBS-CC2 | 1304 | 0.46 | 9.76 ± 1.09 | 9.39 ± 1.01 | 9.30 ± 1.02 | 0.023 (0.004) | 3.29 × 10−8 |
| Total | 8586 | — | — | — | — | 0.016 (0.001) | 1.08 × 10−24 |
| Meta-analysis of other blood cell indices | |||||||
| Platelet count, ×109/L | — | — | — | — | — | −4.553 (0.802) | 7.19 × 10−8 |
| Hemoglobin concentration, g/dL | — | — | — | — | — | −0.020 (0.013) | .119 |
| RBC count, log 1012/L | — | — | — | — | — | −0.002 (0.001) | .070 |
| WBC count, log 109/L | — | — | — | — | — | −0.001 (0.004) | .730 |
| MCH, pg | — | — | — | — | — | 0.018 (0.025) | .509 |
| MCHC, g/dL | — | — | — | — | — | −0.006 (0.011) | .516 |
| MCV, fL | — | — | — | — | — | 0.087 (0.064) | .163 |
| . | Subjects, n . | G allele frequency . | Mean ± SD level of MPV, fL . | Per-G allele effect (SE), log (fL)* . | P . | ||
|---|---|---|---|---|---|---|---|
| GG . | GC . | CC . | |||||
| Cohort | |||||||
| UKBS-CC1 | 1221 | 0.46 | 9.62 ± 1.02 | 9.50 ± 1.03 | 9.21 ± 0.88 | 0.022 (0.004) | 2.21 × 10−7 |
| TwinsUK | 1050 | 0.46 | 11.29 ± 1.10 | 11.06 ± 1.06 | 10.94 ± 0.93 | 0.014 (0.004) | 3.08 × 10−4 |
| KORA F3 500K | 1601 | 0.45 | 8.81 ± 1.02 | 8.71 ± 0.91 | 8.56 ± 0.90 | 0.014 (0.004) | 1.6 × 10−4 |
| CBR | 3410 | 0.45 | 9.63 ± 0.93 | 9.02 ± 0.91 | 8.93 ± 0.91 | 0.013 (0.002) | 2.03 × 10−7 |
| UKBS-CC2 | 1304 | 0.46 | 9.76 ± 1.09 | 9.39 ± 1.01 | 9.30 ± 1.02 | 0.023 (0.004) | 3.29 × 10−8 |
| Total | 8586 | — | — | — | — | 0.016 (0.001) | 1.08 × 10−24 |
| Meta-analysis of other blood cell indices | |||||||
| Platelet count, ×109/L | — | — | — | — | — | −4.553 (0.802) | 7.19 × 10−8 |
| Hemoglobin concentration, g/dL | — | — | — | — | — | −0.020 (0.013) | .119 |
| RBC count, log 1012/L | — | — | — | — | — | −0.002 (0.001) | .070 |
| WBC count, log 109/L | — | — | — | — | — | −0.001 (0.004) | .730 |
| MCH, pg | — | — | — | — | — | 0.018 (0.025) | .509 |
| MCHC, g/dL | — | — | — | — | — | −0.006 (0.011) | .516 |
| MCV, fL | — | — | — | — | — | 0.087 (0.064) | .163 |
MPV indicates mean platelet volume; SD, standard deviation; UKBS-CC, UK Blood Services Common Controls; KORA, Kooperative Gesundheitsforschung in der Region Augsburg; CBR, Cambridge BioResource; RBC, red blood cell; WBC, white blood cell; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; and MCV, mean RBC volume.
After adjustment for age and sex, the proportion of total variation in MPV explained by rs342293 is UKBS-CC1, 2.25%; UKBS-CC2, 2.33%; TwinsUK, 1.27%; CBR, 0.79%; and KORA F3, 0.89%.