Percentage inhibition of HCD122 on CD40 ligand–induced CLL patient PBMC proliferation, n = 8
| Ab concentration, μg/mL . | huIgG1 . | HCD122 . |
|---|---|---|
| 10 | −49 ± 38 | 88 ± 10 |
| 1 | −53 ± 36 | 74 ± 25 |
| 0.1 | −46 ± 33 | 60 ± 29 |
| 0.01 | −65 ± 48 | 1 ± 23 |
| 0.001 | −48 ± 33 | −17 ± 26 |
| Ab concentration, μg/mL . | huIgG1 . | HCD122 . |
|---|---|---|
| 10 | −49 ± 38 | 88 ± 10 |
| 1 | −53 ± 36 | 74 ± 25 |
| 0.1 | −46 ± 33 | 60 ± 29 |
| 0.01 | −65 ± 48 | 1 ± 23 |
| 0.001 | −48 ± 33 | −17 ± 26 |
Percentage inhibition: 100 − (RLU with Abs-PBMCs alone)/(RLU of PBMCs with rhsCD40L-PBMCs alone) × 100%.