Relative risk of lymphoproliferative malignancies and MGUS among first-degree relatives of LPL/WM patients by sex of relative, type of relative, and age of probands at diagnosis
| Variable . | Risk among first-degree relatives . | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LPL/WM . | NHL . | CLL . | HL . | MM . | MGUS . | |||||||||||||
| Pts . | Co . | RR (95% CI)* . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | |
| Sex of relative | ||||||||||||||||||
| Male | 6 | 1 | 24.4 (2.8-212.1) | 23 | 35 | 2.7 (1.6-4.5) | 7 | 13 | 2.2 (0.9-5.4) | 4 | 9 | 1.7 (0.5-5.7) | 5 | 12 | 1.7 (0.6-4.9) | 3 | 2 | 6.1 (1.0-37.2) |
| Female | 4 | 1 | 15.7 (1.8-139.3) | 20 | 23 | 3.4 (1.8-6.4) | 9 | 6 | 5.9 (2.1-16.4) | 0 | 12 | 0 | 6 | 15 | 1.6 (0.6-4.0) | 2 | 2 | 4.0 (0.6-28.1) |
| Type of relative | ||||||||||||||||||
| Parent | 4 | 1 | 15.9 (1.8-140.1) | 16 | 17 | 3.7 (1.9-7.3) | 11 | 9 | 4.8 (2.0-11.6) | 0 | 6 | 0 | 7 | 15 | 1.8 (0.7-4.4) | 0 | 1 | 0 |
| Sibling | 0 | 0 | NA | 11 | 10 | 4.7 (2.0-11.0) | 3 | 2 | 6.3 (1.1-37.2) | 0 | 3 | 0 | 3 | 4 | 3.1 (0.7-13.8) | 2 | 0 | inf* |
| Offspring | 6 | 1 | 24.4 (2.7-216.8) | 16 | 31 | 2.1 (1.1-3.8) | 2 | 8 | 1.0 (0.2-4.9) | 4 | 12 | 1.3 (0.4-4.0) | 1 | 8 | 0.5 (0.1-4.0) | 3 | 3 | 4.1 (0.8-20.6) |
| Age at diagnosis† | ||||||||||||||||||
| < 70 y | 4 | 2 | 8.0 (1.5-43.1) | 29 | 33 | 3.5 (2.2-5.8) | 14 | 11 | 5.1 (2.3-11.1) | 2 | 13 | 0.6 (0.1-2.8) | 10 | 19 | 2.1 (1.0-4.5) | 2 | 1 | 8.2 (0.7-93.2) |
| > 70 y | 6 | 0 | inf* | 14 | 25 | 2.2 (1.1-4.4) | 2 | 8 | 1.0 (0.2-4.9) | 2 | 8 | 1.0 (0.2-4.6) | 1 | 8 | 0.5 (0.1-3.9) | 3 | 3 | 4.0 (0.8-20.3) |
| Variable . | Risk among first-degree relatives . | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LPL/WM . | NHL . | CLL . | HL . | MM . | MGUS . | |||||||||||||
| Pts . | Co . | RR (95% CI)* . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | Pts . | Co . | RR (95% CI) . | |
| Sex of relative | ||||||||||||||||||
| Male | 6 | 1 | 24.4 (2.8-212.1) | 23 | 35 | 2.7 (1.6-4.5) | 7 | 13 | 2.2 (0.9-5.4) | 4 | 9 | 1.7 (0.5-5.7) | 5 | 12 | 1.7 (0.6-4.9) | 3 | 2 | 6.1 (1.0-37.2) |
| Female | 4 | 1 | 15.7 (1.8-139.3) | 20 | 23 | 3.4 (1.8-6.4) | 9 | 6 | 5.9 (2.1-16.4) | 0 | 12 | 0 | 6 | 15 | 1.6 (0.6-4.0) | 2 | 2 | 4.0 (0.6-28.1) |
| Type of relative | ||||||||||||||||||
| Parent | 4 | 1 | 15.9 (1.8-140.1) | 16 | 17 | 3.7 (1.9-7.3) | 11 | 9 | 4.8 (2.0-11.6) | 0 | 6 | 0 | 7 | 15 | 1.8 (0.7-4.4) | 0 | 1 | 0 |
| Sibling | 0 | 0 | NA | 11 | 10 | 4.7 (2.0-11.0) | 3 | 2 | 6.3 (1.1-37.2) | 0 | 3 | 0 | 3 | 4 | 3.1 (0.7-13.8) | 2 | 0 | inf* |
| Offspring | 6 | 1 | 24.4 (2.7-216.8) | 16 | 31 | 2.1 (1.1-3.8) | 2 | 8 | 1.0 (0.2-4.9) | 4 | 12 | 1.3 (0.4-4.0) | 1 | 8 | 0.5 (0.1-4.0) | 3 | 3 | 4.1 (0.8-20.6) |
| Age at diagnosis† | ||||||||||||||||||
| < 70 y | 4 | 2 | 8.0 (1.5-43.1) | 29 | 33 | 3.5 (2.2-5.8) | 14 | 11 | 5.1 (2.3-11.1) | 2 | 13 | 0.6 (0.1-2.8) | 10 | 19 | 2.1 (1.0-4.5) | 2 | 1 | 8.2 (0.7-93.2) |
| > 70 y | 6 | 0 | inf* | 14 | 25 | 2.2 (1.1-4.4) | 2 | 8 | 1.0 (0.2-4.9) | 2 | 8 | 1.0 (0.2-4.6) | 1 | 8 | 0.5 (0.1-3.9) | 3 | 3 | 4.0 (0.8-20.3) |
RR indicates relative risk; CI, confidence interval; LPL, lymphoplasmacytic lymphoma; WM, Waldenström macroglobulinemia; NHL, non-Hodgkin lymphoma; CLL, chronic lymphocytic leukemia; HL, Hodgkin lymphoma; MM, multiple myeloma; MGUS, monoclonal gammopathy of undetermined significance; Pts, patients; Co, controls; NA, not applicable; and inf*, infinity.
All estimates were adjusted for sex of first-degree relative.
Age at diagnosis for corresponding proband.