Relative risk of lymphoproliferative malignancies and MGUS among first-degree relatives of LPL/WM patients
| . | Risk among first-degree relatives . | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Relatives of LPL pts only . | Relatives of WM pts only . | Relatives of LPL/WM pts combined . | |||||||
| Pts . | Co . | RR (95% CI)* . | Pts . | Co . | RR (95% CI)* . | Pts . | Co . | RR (95% CI)* . | |
| LPL/WM | 4 | 1 | 16.6 (1.7-162.2) | 6 | 1 | 24.0 (2.9-201.1) | 10 | 2 | 20.0 (4.1-98.4) |
| Non-Hodgkin lymphoma | 15 | 26 | 2.3 (1.2-4.3) | 28 | 32 | 3.5 (2.1-5.8) | 43 | 58 | 3.0 (2.0-4.4) |
| Chronic lymphocytic leukemia | 7 | 6 | 4.8 (1.6-14.1) | 9 | 13 | 2.7 (1.1-6.5) | 16 | 19 | 3.4 (1.7-6.6) |
| Hodgkin lymphoma | 3 | 2 | 5.9 (1.0-36.0) | 1 | 19 | 0.2 (0.0-1.5) | 4 | 21 | 0.8 (0.3-2.2) |
| Multiple myeloma | 6 | 11 | 2.2 (0.8-5.9) | 5 | 16 | 1.2 (0.4-3.3) | 11 | 27 | 1.6 (0.8-3.2) |
| MGUS | 2 | 1 | 8.1 (0.7-90.6) | 3 | 3 | 4.0 (0.8-20.0) | 5 | 4 | 5.0 (1.3-18.9) |
| . | Risk among first-degree relatives . | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Relatives of LPL pts only . | Relatives of WM pts only . | Relatives of LPL/WM pts combined . | |||||||
| Pts . | Co . | RR (95% CI)* . | Pts . | Co . | RR (95% CI)* . | Pts . | Co . | RR (95% CI)* . | |
| LPL/WM | 4 | 1 | 16.6 (1.7-162.2) | 6 | 1 | 24.0 (2.9-201.1) | 10 | 2 | 20.0 (4.1-98.4) |
| Non-Hodgkin lymphoma | 15 | 26 | 2.3 (1.2-4.3) | 28 | 32 | 3.5 (2.1-5.8) | 43 | 58 | 3.0 (2.0-4.4) |
| Chronic lymphocytic leukemia | 7 | 6 | 4.8 (1.6-14.1) | 9 | 13 | 2.7 (1.1-6.5) | 16 | 19 | 3.4 (1.7-6.6) |
| Hodgkin lymphoma | 3 | 2 | 5.9 (1.0-36.0) | 1 | 19 | 0.2 (0.0-1.5) | 4 | 21 | 0.8 (0.3-2.2) |
| Multiple myeloma | 6 | 11 | 2.2 (0.8-5.9) | 5 | 16 | 1.2 (0.4-3.3) | 11 | 27 | 1.6 (0.8-3.2) |
| MGUS | 2 | 1 | 8.1 (0.7-90.6) | 3 | 3 | 4.0 (0.8-20.0) | 5 | 4 | 5.0 (1.3-18.9) |
RR indicates relative risk; CI, confidence interval; LPL, lymphoplasmacytic lymphoma; WM, Waldenström macroglobulinemia; MGUS, monoclonal gammopathy of undetermined significance; Pts, patients; and Co, controls.
All estimates were adjusted for sex of first-degree relative.