Table 2 Genotyping results of SNPs in... | American Society of Hematology

Table 2

Genotyping results of SNPs in the FCGR2 and FCGR3 genes

	Controls	All ITP	Adult ITP	Children ITP
*FCGR2A*
Genotype frequency
131RR	20 (20)	27 (23.3)	8 (18.2)	19 (26.3)
131HR	52 (52)	54 (46.6)	26 (59.1)	28 (38.9)
131HH	28 (28)	35 (30.2)	10 (22.7)	25 (34.7)
Allele frequency
131R	92 (46)	108 (46.6)	42 (47.7)	66 (45.8)
131H	108 (54)	124 (53.4)*	46 (52.3)*	78 (54.2)*
*FCGR2B*
Genotype frequency
232II	81 (81)	97 (83.6)	37 (84.1)	60 (83.3)
232IT	15 (15)	15 (12.9)	5 (11.4)	10 (13.9)
232TT	4 (4)	4 (3.4)	2 (4.5)	2 (2.8)
Allele frequency
232I	177 (88.5)	209 (90.1)	79 (89.8)	130 (90.2)
232T	23 (11.5)	23 (9.9)*	9 (10.2)*	14 (9.7)*
*FCGR3A*
Genotype frequency
158F	0 (0)	3 (2.6)	2 (4.5)	1 (1.4)
158FF	48 (48)	30 (25.9)	15 (34.1)	15 (20.8)
158FFF	1 (1)	2 (1.7)	2 (4.5)	0 (0)
158V	1 (1)	1 (0.9)	0 (0)	1 (1.4)
158VV	7 (7)	23 (19.8)	8 (18.2)	15 (20.8)
158VVV	1 (1)	0 (0)	0 (0)	0 (0)
158VF	41 (41)	55 (47.4)	16 (36.4)	39 (54.1)
158VVF	1 (1)	0 (0)	0 (0)	0 (0)
158VFF	0 (0)	2 (1.7)	1 (2.3)	1 (1.4)
Allele frequency
158F	141 (69.5)	128 (55.2)	56 (62.9)	72 (50.3)
158V	62 (30.5)	104 (44.8)†	33 (37.1)‡	71 (49.7)§
*FCGR3B*
Genotype frequency
HNA1a	4 (4)	4 (3.4)	0 (0)	4 (5.6)
HNA1aHNA1a	13 (13)	13 (11.2)	5 (11.4)	8 (11.1)
HNA1aHNA1aHNA1	0 (0)	0 (0)	0 (0)	0 (0)
HNA1b	3 (3)	2 (1.7)	0 (0)	2 (2.8)
HNA1bHNA1b	34 (34)	55 (47.4)	22 (50.0)	33 (45.8)
HNA1bHNA1bHNA1b	1 (1)	0 (0)	0 (0)	0 (0)
HNA1aHNA1b	35 (35)	35 (30.2)	14 (31.8)	21 (29.2)
HNA1aHNA1aHNA1b	2 (2)	1 (0.9)	0 (0)	1 (1.4)
HNA1aHNA1bHNA1b	8 (8)	6 (5.2)	3 (6.8)	3 (4.2)
Allele frequency
HNA1a	77 (37.7)	73 (31.3)	27 (29.7)	46 (32.4)
HNA1b	127 (62.3)	160 (68.7)*	64 (70.3)*	96 (67.6)*
HNA1c (SH)	4 (4)	5 (4.3)*	1 (2.3)*	4 (5.6)*

	Controls	All ITP	Adult ITP	Children ITP
*FCGR2A*
Genotype frequency
131RR	20 (20)	27 (23.3)	8 (18.2)	19 (26.3)
131HR	52 (52)	54 (46.6)	26 (59.1)	28 (38.9)
131HH	28 (28)	35 (30.2)	10 (22.7)	25 (34.7)
Allele frequency
131R	92 (46)	108 (46.6)	42 (47.7)	66 (45.8)
131H	108 (54)	124 (53.4)*	46 (52.3)*	78 (54.2)*
*FCGR2B*
Genotype frequency
232II	81 (81)	97 (83.6)	37 (84.1)	60 (83.3)
232IT	15 (15)	15 (12.9)	5 (11.4)	10 (13.9)
232TT	4 (4)	4 (3.4)	2 (4.5)	2 (2.8)
Allele frequency
232I	177 (88.5)	209 (90.1)	79 (89.8)	130 (90.2)
232T	23 (11.5)	23 (9.9)*	9 (10.2)*	14 (9.7)*
*FCGR3A*
Genotype frequency
158F	0 (0)	3 (2.6)	2 (4.5)	1 (1.4)
158FF	48 (48)	30 (25.9)	15 (34.1)	15 (20.8)
158FFF	1 (1)	2 (1.7)	2 (4.5)	0 (0)
158V	1 (1)	1 (0.9)	0 (0)	1 (1.4)
158VV	7 (7)	23 (19.8)	8 (18.2)	15 (20.8)
158VVV	1 (1)	0 (0)	0 (0)	0 (0)
158VF	41 (41)	55 (47.4)	16 (36.4)	39 (54.1)
158VVF	1 (1)	0 (0)	0 (0)	0 (0)
158VFF	0 (0)	2 (1.7)	1 (2.3)	1 (1.4)
Allele frequency
158F	141 (69.5)	128 (55.2)	56 (62.9)	72 (50.3)
158V	62 (30.5)	104 (44.8)†	33 (37.1)‡	71 (49.7)§
*FCGR3B*
Genotype frequency
HNA1a	4 (4)	4 (3.4)	0 (0)	4 (5.6)
HNA1aHNA1a	13 (13)	13 (11.2)	5 (11.4)	8 (11.1)
HNA1aHNA1aHNA1	0 (0)	0 (0)	0 (0)	0 (0)
HNA1b	3 (3)	2 (1.7)	0 (0)	2 (2.8)
HNA1bHNA1b	34 (34)	55 (47.4)	22 (50.0)	33 (45.8)
HNA1bHNA1bHNA1b	1 (1)	0 (0)	0 (0)	0 (0)
HNA1aHNA1b	35 (35)	35 (30.2)	14 (31.8)	21 (29.2)
HNA1aHNA1aHNA1b	2 (2)	1 (0.9)	0 (0)	1 (1.4)
HNA1aHNA1bHNA1b	8 (8)	6 (5.2)	3 (6.8)	3 (4.2)
Allele frequency
HNA1a	77 (37.7)	73 (31.3)	27 (29.7)	46 (32.4)
HNA1b	127 (62.3)	160 (68.7)*	64 (70.3)*	96 (67.6)*
HNA1c (SH)	4 (4)	5 (4.3)*	1 (2.3)*	4 (5.6)*

Due to CNV, the 3-allelic variation was observed for FCGR3A-158VF and FCGR3B-HNA1aHNA1b. Data are no. (%). Significance levels are indicated by symbols.

P is not significant.

†

P is .003.

‡

P is .3.

P is less than .001.

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