Disrupted cytokine distribution in peripheral blood of SHIP-deficient mice
| Cytokine . | SHIP−/− . | WT . | P . |
|---|---|---|---|
| TPO (ng/mL) | 13.36 ± 0.3636 (n = 11) | 11.79 ± 0.2143 (n = 14) | < .001 |
| G-CSF (pg/mL) | 749.1 ± 39.13 (n = 4) | 161.9 ± 24.62 (n = 4) | < .001 |
| IL-6 (pg/mL) | 39.82 ± 6.201 (n = 11) | 13.67 ± 0.5205 (n = 13) | < .001 |
| IL-5 (ng/mL) | 0.2147 ± 0.0235 (n = 11) | 0.1511 ± 0.01634 (n = 14) | .031 |
| MMP-9 (ng/mL) | 476.3 ± 60.59 (n = 11) | 175.6 ± 23.3 (n = 14) | < .001 |
| VCAM-1 (ng/mL) | 2771 ± 82.06 (n = 11) | 1862 ± 70.14 (n = 14) | < .001 |
| Cytokine . | SHIP−/− . | WT . | P . |
|---|---|---|---|
| TPO (ng/mL) | 13.36 ± 0.3636 (n = 11) | 11.79 ± 0.2143 (n = 14) | < .001 |
| G-CSF (pg/mL) | 749.1 ± 39.13 (n = 4) | 161.9 ± 24.62 (n = 4) | < .001 |
| IL-6 (pg/mL) | 39.82 ± 6.201 (n = 11) | 13.67 ± 0.5205 (n = 13) | < .001 |
| IL-5 (ng/mL) | 0.2147 ± 0.0235 (n = 11) | 0.1511 ± 0.01634 (n = 14) | .031 |
| MMP-9 (ng/mL) | 476.3 ± 60.59 (n = 11) | 175.6 ± 23.3 (n = 14) | < .001 |
| VCAM-1 (ng/mL) | 2771 ± 82.06 (n = 11) | 1862 ± 70.14 (n = 14) | < .001 |
Values are mean plus or minus SEM. Various factors were measured in serum obtained from PB by ELISA. The data are pooled from multiple assays derived from at least 4 different plasma samples for each genotype. Significance was established using the unpaired Student t test.