Lymphopenia in the mother does not rescue Thbd−/− embryos
| Breeding pair (female × male) . | Genotype of offspring . | ||
|---|---|---|---|
| Thbd+/+ . | Thbd+/− . | Thbd−/− . | |
| Thbd+/−Rag-1−/− × Thbd+/−; n = 35 | 12 | 23 | 0 |
| Thbd+/−γC−/− × Thbd+/−; n = 40 | 12 | 18 | 0 |
| Thbd+/−Rag-2−/−γC−/− × Thbd+/−; n = 30 | 7 | 16 | 0 |
| Breeding pair (female × male) . | Genotype of offspring . | ||
|---|---|---|---|
| Thbd+/+ . | Thbd+/− . | Thbd−/− . | |
| Thbd+/−Rag-1−/− × Thbd+/−; n = 35 | 12 | 23 | 0 |
| Thbd+/−γC−/− × Thbd+/−; n = 40 | 12 | 18 | 0 |
| Thbd+/−Rag-2−/−γC−/− × Thbd+/−; n = 30 | 7 | 16 | 0 |
In these experiments the mother lacked lymphocytes (Rag1−/−), NK cells (γc−/−), or both (Rag2−/−γc−/−). Pregnancies were analyzed at 9.5 dpc. Numbers represent embryos that had progressed beyond Theiler stage 13. All Thbd−/− embryos obtained from these crosses were in advanced stages of decay.